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1.

Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.

Kedei N, Lewin NE, Géczy T, Selezneva J, Braun DC, Chen J, Herrmann MA, Heldman MR, Lim L, Mannan P, Garfield SH, Poudel YB, Cummins TJ, Rudra A, Blumberg PM, Keck GE.

ACS Chem Biol. 2013 Apr 19;8(4):767-77. doi: 10.1021/cb300671s. Epub 2013 Feb 1.

2.

The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line.

Kedei N, Telek A, Czap A, Lubart ES, Czifra G, Yang D, Chen J, Morrison T, Goldsmith PK, Lim L, Mannan P, Garfield SH, Kraft MB, Li W, Keck GE, Blumberg PM.

Biochem Pharmacol. 2011 Jun 1;81(11):1296-308. doi: 10.1016/j.bcp.2011.03.018. Epub 2011 Mar 30.

3.
4.

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro.

DeChristopher BA, Loy BA, Marsden MD, Schrier AJ, Zack JA, Wender PA.

Nat Chem. 2012 Sep;4(9):705-10. doi: 10.1038/nchem.1395. Epub 2012 Jul 15.

5.

Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.

Keck GE, Poudel YB, Rudra A, Stephens JC, Kedei N, Lewin NE, Blumberg PM.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4084-8. doi: 10.1016/j.bmcl.2012.04.073. Epub 2012 Apr 24.

6.

The chemistry and biology of the bryostatins: potential PKC inhibitors in clinical development.

Ruan BF, Zhu HL.

Curr Med Chem. 2012;19(16):2652-64. Review.

PMID:
22506770
7.
8.

The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.

Wender PA, Verma VA.

Org Lett. 2008 Aug 7;10(15):3331-4. doi: 10.1021/ol801235h. Epub 2008 Jun 28.

9.

The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.

Szallasi Z, Du L, Levine R, Lewin NE, Nguyen PN, Williams MD, Pettit GR, Blumberg PM.

Cancer Res. 1996 May 1;56(9):2105-11.

11.

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity.

Wender PA, Baryza JL, Brenner SE, DeChristopher BA, Loy BA, Schrier AJ, Verma VA.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6721-6. doi: 10.1073/pnas.1015270108. Epub 2011 Mar 17.

12.

The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha.

Clarke H, Ginanni N, Laughlin KV, Smith JB, Pettit GR, Mullin JM.

Exp Cell Res. 2000 Nov 25;261(1):239-49.

PMID:
11082294
13.

Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.

Szallasi Z, Denning MF, Smith CB, Dlugosz AA, Yuspa SH, Pettit GR, Blumberg PM.

Mol Pharmacol. 1994 Nov;46(5):840-50.

PMID:
7969070
14.

Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.

Wender PA, Nakagawa Y, Near KE, Staveness D.

Org Lett. 2014 Oct 3;16(19):5136-9. doi: 10.1021/ol502491f. Epub 2014 Sep 19.

PMID:
25238583
15.

Function oriented synthesis: the design, synthesis, PKC binding and translocation activity of a new bryostatin analog.

Wender PA, Baryza JL, Brenner SE, Clarke MO, Craske ML, Horan JC, Meyer T.

Curr Drug Discov Technol. 2004 Jan;1(1):1-11.

PMID:
16472215
16.

Bryostatin-1 stimulates the transcription of cyclooxygenase-2: evidence for an activator protein-1-dependent mechanism.

De Lorenzo MS, Yamaguchi K, Subbaramaiah K, Dannenberg AJ.

Clin Cancer Res. 2003 Oct 15;9(13):5036-43.

17.

Bryostatins selectively regulate protein kinase C-mediated effects on GH4 cell proliferation.

Mackanos EA, Pettit GR, Ramsdell JS.

J Biol Chem. 1991 Jun 15;266(17):11205-12.

18.

Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.

Irie K, Yanagita RC.

Chem Rec. 2014 Apr;14(2):251-67. doi: 10.1002/tcr.201300036. Epub 2014 Feb 20. Review.

PMID:
24677503
19.

Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.

Wender PA, Staveness D.

Org Lett. 2014 Oct 3;16(19):5140-3. doi: 10.1021/ol502492b. Epub 2014 Sep 19.

PMID:
25238640
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