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Results: 1 to 20 of 107

1.

Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase.

Daubner SC, Avila A, Bailey JO, Barrera D, Bermudez JY, Giles DH, Khan CA, Shaheen N, Thompson JW, Vasquez J, Oxley SP, Fitzpatrick PF.

Biochemistry. 2013 Feb 26;52(8):1446-55. doi: 10.1021/bi400031n. Epub 2013 Feb 13.

PMID:
23368961
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A flexible loop in tyrosine hydroxylase controls coupling of amino acid hydroxylation to tetrahydropterin oxidation.

Daubner SC, McGinnis JT, Gardner M, Kroboth SL, Morris AR, Fitzpatrick PF.

J Mol Biol. 2006 Jun 2;359(2):299-307. Epub 2006 Mar 24.

PMID:
16618490
[PubMed - indexed for MEDLINE]
Free PMC Article
3.
4.

Demonstration of a peroxide shunt in the tetrahydropterin-dependent aromatic amino acid monooxygenases.

Pavon JA, Fitzpatrick PF.

J Am Chem Soc. 2009 Apr 8;131(13):4582-3. doi: 10.1021/ja900128m.

PMID:
19281164
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Reversing the substrate specificities of phenylalanine and tyrosine hydroxylase: aspartate 425 of tyrosine hydroxylase is essential for L-DOPA formation.

Daubner SC, Melendez J, Fitzpatrick PF.

Biochemistry. 2000 Aug 15;39(32):9652-61.

PMID:
10933781
[PubMed - indexed for MEDLINE]
6.

Phenylalanine residues in the active site of tyrosine hydroxylase: mutagenesis of Phe300 and Phe309 to alanine and metal ion-catalyzed hydroxylation of Phe300.

Ellis HR, Daubner SC, McCulloch RI, Fitzpatrick PF.

Biochemistry. 1999 Aug 24;38(34):10909-14.

PMID:
10460145
[PubMed - indexed for MEDLINE]
7.

Mutation to phenylalanine of tyrosine 371 in tyrosine hydroxylase increases the affinity for phenylalanine.

Daubner SC, Fitzpatrick PF.

Biochemistry. 1998 Nov 17;37(46):16440-4.

PMID:
9819237
[PubMed - indexed for MEDLINE]
8.

Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.

Zhang W, Ames BD, Walsh CT.

Biochemistry. 2011 Jun 21;50(24):5401-3. doi: 10.1021/bi200733c. Epub 2011 May 31.

PMID:
21615132
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Mutation of serine 395 of tyrosine hydroxylase decouples oxygen-oxygen bond cleavage and tyrosine hydroxylation.

Ellis HR, Daubner SC, Fitzpatrick PF.

Biochemistry. 2000 Apr 11;39(14):4174-81.

PMID:
10747809
[PubMed - indexed for MEDLINE]
10.

The aromatic amino acid hydroxylases.

Fitzpatrick PF.

Adv Enzymol Relat Areas Mol Biol. 2000;74:235-94. Review.

PMID:
10800597
[PubMed - indexed for MEDLINE]
11.

Characterization of chimeric pterin-dependent hydroxylases: contributions of the regulatory domains of tyrosine and phenylalanine hydroxylase to substrate specificity.

Daubner SC, Hillas PJ, Fitzpatrick PF.

Biochemistry. 1997 Sep 30;36(39):11574-82.

PMID:
9305947
[PubMed - indexed for MEDLINE]
12.

Lysine241 of tyrosine hydroxylase is not required for binding of tetrahydrobiopterin substrate.

Daubner SC, Fitzpatrick PF.

Arch Biochem Biophys. 1993 May;302(2):455-60.

PMID:
8098196
[PubMed - indexed for MEDLINE]
13.

Pulsed EPR study of amino acid and tetrahydropterin binding in a tyrosine hydroxylase nitric oxide complex: evidence for substrate rearrangements in the formation of the oxygen-reactive complex.

Krzyaniak MD, Eser BE, Ellis HR, Fitzpatrick PF, McCracken J.

Biochemistry. 2013 Nov 26;52(47):8430-41. doi: 10.1021/bi4010914. Epub 2013 Nov 14.

PMID:
24168553
[PubMed - indexed for MEDLINE]
Free PMC Article
14.
15.
17.

A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines.

Hillas PJ, Fitzpatrick PF.

Biochemistry. 1996 Jun 4;35(22):6969-75.

PMID:
8679520
[PubMed - indexed for MEDLINE]
18.

Role of the second coordination sphere residue tyrosine 179 in substrate affinity and catalytic activity of phenylalanine hydroxylase.

Zoidakis J, Sam M, Volner A, Han A, Vu K, Abu-Omar MM.

J Biol Inorg Chem. 2004 Apr;9(3):289-96. Epub 2004 Mar 4.

PMID:
14999516
[PubMed - indexed for MEDLINE]
19.

Mechanism of "uncoupled" tetrahydropterin oxidation by phenylalanine hydroxylase.

Dix TA, Benkovic SJ.

Biochemistry. 1985 Oct 8;24(21):5839-46.

PMID:
4084494
[PubMed - indexed for MEDLINE]
20.

Identification of Gln313 and Pro327 as residues critical for substrate inhibition in tyrosine hydroxylase.

Quinsey NS, Lenaghan CM, Dickson PW.

J Neurochem. 1996 Mar;66(3):908-14.

PMID:
8769848
[PubMed - indexed for MEDLINE]

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