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J Nutr Health Aging. 2013 Feb;17(2):166-72. doi: 10.1007/s12603-012-0372-x.

A probiotics-containing biscuit modulates the intestinal microbiota in the elderly.

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  • 1Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy.

Abstract

OBJECTIVES:

Evaluation of the impact of a biscuit containing the probiotics Bifidobacterium longum Bar33 and Lactobacillus helveticus Bar13 on the intestinal microbiota in the elderly.

DESIGN:

Randomized double-blind placebo-controlled trial.

PARTICIPANTS:

Thirty-two elderly volunteers living in Italy. The group was composed of 19 women and 13 men aged between 71 and 88 years (mean 76).

INTERVENTION:

Subjects were randomized in two groups consuming one dose of the probiotics-containing biscuit or placebo once a day for 30 days.

MEASUREMENTS:

For each subject the intestinal microbiota was characterized using the phylogenetic microarray platform HTF-Microbi.Array before and after intervention.

RESULTS:

Our data demonstrated that one-month consumption of a probiotics-containing biscuit was effective in redressing some of the age-related dysbioses of the intestinal microbiota. In particular, the probiotic treatment reverted the age-related increase of the opportunistic pathogens Clostridium cluster XI, Clostridium difficile, Clostridium perfringens, Enterococcus faecium and the enteropathogenic genus Campylobacter.

CONCLUSION:

The present study opens the way to the development of elderly-tailored probiotic-based functional foods to counteract the age-related dysbioses of the intestinal microbiota.

PMID:
23364497
[PubMed - indexed for MEDLINE]
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