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Items: 1 to 20 of 111

1.

Role of cytochrome P4502B6 in methadone metabolism and clearance.

Kharasch ED, Stubbert K.

J Clin Pharmacol. 2013 Mar;53(3):305-13. doi: 10.1002/jcph.1. Epub 2013 Jan 7.

2.

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.

Kharasch ED, Hoffer C, Whittington D, Sheffels P.

Clin Pharmacol Ther. 2004 Sep;76(3):250-69.

PMID:
15371986
3.

Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.

Kharasch ED, Whittington D, Ensign D, Hoffer C, Bedynek PS, Campbell S, Stubbert K, Crafford A, London A, Kim T.

Clin Pharmacol Ther. 2012 Apr;91(4):673-84. doi: 10.1038/clpt.2011.276. Epub 2012 Mar 7.

4.

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

Gerber JG, Rhodes RJ, Gal J.

Chirality. 2004 Jan;16(1):36-44.

PMID:
14628297
5.

Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.

Kharasch ED, Walker A, Whittington D, Hoffer C, Bedynek PS.

Drug Alcohol Depend. 2009 May 1;101(3):158-68. doi: 10.1016/j.drugalcdep.2008.12.009. Epub 2009 Feb 18.

6.

Enantiomeric metabolic interactions and stereoselective human methadone metabolism.

Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED.

J Pharmacol Exp Ther. 2007 Apr;321(1):389-99. Epub 2007 Jan 26.

7.

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction.

Hagelberg NM, Saarikoski T, Saari TI, Neuvonen M, Neuvonen PJ, Turpeinen M, Scheinin M, Laine K, Olkkola KT.

Eur J Clin Pharmacol. 2013 Apr;69(4):867-75. doi: 10.1007/s00228-012-1433-0. Epub 2012 Oct 26.

PMID:
23099620
8.

Mechanism of autoinduction of methadone N-demethylation in human hepatocytes.

Campbell SD, Crafford A, Williamson BL, Kharasch ED.

Anesth Analg. 2013 Jul;117(1):52-60. doi: 10.1213/ANE.0b013e3182918252. Epub 2013 Jun 3.

9.

Role of CYP2B6 in stereoselective human methadone metabolism.

Totah RA, Sheffels P, Roberts T, Whittington D, Thummel K, Kharasch ED.

Anesthesiology. 2008 Mar;108(3):363-74. doi: 10.1097/ALN.0b013e3181642938.

PMID:
18292673
10.

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment.

Crettol S, Déglon JJ, Besson J, Croquette-Krokkar M, Gothuey I, Hämmig R, Monnat M, Hüttemann H, Baumann P, Eap CB.

Clin Pharmacol Ther. 2005 Dec;78(6):593-604.

PMID:
16338275
11.

Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

Gadel S, Crafford A, Regina K, Kharasch ED.

Drug Metab Dispos. 2013 Apr;41(4):709-13. doi: 10.1124/dmd.112.050625. Epub 2013 Jan 8.

12.

Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.

Amunugama HT, Zhang H, Hollenberg PF.

Drug Metab Dispos. 2012 Sep;40(9):1765-70. doi: 10.1124/dmd.112.045971. Epub 2012 Jun 8.

13.

Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation.

Chang Y, Fang WB, Lin SN, Moody DE.

Basic Clin Pharmacol Toxicol. 2011 Jan;108(1):55-62. doi: 10.1111/j.1742-7843.2010.00628.x. Epub 2010 Sep 2.

14.

Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4.

Casabar RC, Wallace AD, Hodgson E, Rose RL.

Drug Metab Dispos. 2006 Oct;34(10):1779-85. Epub 2006 Jul 19.

15.

CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

Levran O, Peles E, Hamon S, Randesi M, Adelson M, Kreek MJ.

Addict Biol. 2013 Jul;18(4):709-16. doi: 10.1111/j.1369-1600.2011.00349.x. Epub 2011 Jul 25.

16.

Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.

Kharasch ED, Regina KJ, Blood J, Friedel C.

Anesthesiology. 2015 Nov;123(5):1142-53. doi: 10.1097/ALN.0000000000000867.

PMID:
26389554
17.
18.

Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.

Kharasch ED, Hoffer C, Walker A, Sheffels P.

Clin Pharmacol Ther. 2003 Mar;73(3):199-208.

PMID:
12621385
19.

Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.

Kharasch ED, Mitchell D, Coles R, Blanco R.

Antimicrob Agents Chemother. 2008 May;52(5):1663-9. doi: 10.1128/AAC.01600-07. Epub 2008 Feb 19.

20.

Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir.

Kharasch ED, Stubbert K.

Drug Metab Dispos. 2013 Dec;41(12):2166-74. doi: 10.1124/dmd.113.053991. Epub 2013 Sep 25.

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