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Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1.

Fan R, Kim NG, Gumbiner BM.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2569-74. doi: 10.1073/pnas.1216462110. Epub 2013 Jan 28.


E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.

Kim NG, Koh E, Chen X, Gumbiner BM.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11930-5. doi: 10.1073/pnas.1103345108. Epub 2011 Jul 5.


Adhesion to fibronectin regulates Hippo signaling via the FAK-Src-PI3K pathway.

Kim NG, Gumbiner BM.

J Cell Biol. 2015 Aug 3;210(3):503-15. doi: 10.1083/jcb.201501025. Epub 2015 Jul 27.


Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L, Zheng P, Ye K, Chinnaiyan A, Halder G, Lai ZC, Guan KL.

Genes Dev. 2007 Nov 1;21(21):2747-61.


Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP).

Oka T, Mazack V, Sudol M.

J Biol Chem. 2008 Oct 10;283(41):27534-46. doi: 10.1074/jbc.M804380200. Epub 2008 Jul 17.


Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility.

Wang Z, Wu Y, Wang H, Zhang Y, Mei L, Fang X, Zhang X, Zhang F, Chen H, Liu Y, Jiang Y, Sun S, Zheng Y, Li N, Huang L.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E89-98. doi: 10.1073/pnas.1319190110. Epub 2013 Dec 23.


Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein.

Li C, Srivastava RK, Elmets CA, Afaq F, Athar M.

Biochem Biophys Res Commun. 2013 Sep 6;438(4):607-12. doi: 10.1016/j.bbrc.2013.08.008. Epub 2013 Aug 11.


Regulation of YAP by mechanical strain through Jnk and Hippo signaling.

Codelia VA, Sun G, Irvine KD.

Curr Biol. 2014 Sep 8;24(17):2012-7. doi: 10.1016/j.cub.2014.07.034. Epub 2014 Aug 7.


cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.

Kim M, Kim M, Lee S, Kuninaka S, Saya H, Lee H, Lee S, Lim DS.

EMBO J. 2013 May 29;32(11):1543-55. doi: 10.1038/emboj.2013.102. Epub 2013 May 3.


Arhgef7 promotes activation of the Hippo pathway core kinase Lats.

Heidary Arash E, Song KM, Song S, Shiban A, Attisano L.

EMBO J. 2014 Dec 17;33(24):2997-3011. doi: 10.15252/embj.201490230. Epub 2014 Nov 25.


Ret oncogene signal transduction via a IRS-2/PI 3-kinase/PKB and a SHC/Grb-2 dependent pathway: possible implication for transforming activity in NIH3T3 cells.

Hennige AM, Lammers R, Arlt D, Höppner W, Strack V, Niederfellner G, Seif FJ, Häring HU, Kellerer M.

Mol Cell Endocrinol. 2000 Sep 25;167(1-2):69-76.


Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.

Okano J, Gaslightwala I, Birnbaum MJ, Rustgi AK, Nakagawa H.

J Biol Chem. 2000 Oct 6;275(40):30934-42.


EGF-dependent cell cycle progression is controlled by density-dependent regulation of Akt activation.

LeVea CM, Reeder JE, Mooney RA.

Exp Cell Res. 2004 Jul 1;297(1):272-84.


Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling.

Nakamura A, Naito M, Tsuruo T, Fujita N.

Mol Cell Biol. 2008 Oct;28(19):5996-6009. doi: 10.1128/MCB.00114-08. Epub 2008 Jul 28.


Targeting YAP and Hippo signaling pathway in liver cancer.

Liu AM, Xu MZ, Chen J, Poon RT, Luk JM.

Expert Opin Ther Targets. 2010 Aug;14(8):855-68. doi: 10.1517/14728222.2010.499361. Review.


The Hippo pathway is controlled by Angiotensin II signaling and its reactivation induces apoptosis in podocytes.

Wennmann DO, Vollenbröker B, Eckart AK, Bonse J, Erdmann F, Wolters DA, Schenk LK, Schulze U, Kremerskothen J, Weide T, Pavenstädt H.

Cell Death Dis. 2014 Nov 13;5:e1519. doi: 10.1038/cddis.2014.476.


LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade.

Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y.

Oncogene. 2015 Jan 2;34(1):73-83. doi: 10.1038/onc.2013.528. Epub 2013 Dec 16.


A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).

Zhao B, Li L, Tumaneng K, Wang CY, Guan KL.

Genes Dev. 2010 Jan 1;24(1):72-85. doi: 10.1101/gad.1843810.


Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.

Adler JJ, Johnson DE, Heller BL, Bringman LR, Ranahan WP, Conwell MD, Sun Y, Hudmon A, Wells CD.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17368-73. doi: 10.1073/pnas.1308236110. Epub 2013 Oct 7.


Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells.

You B, Yang YL, Xu Z, Dai Y, Liu S, Mao JH, Tetsu O, Li H, Jablons DM, You L.

Oncotarget. 2015 Feb 28;6(6):4357-68.

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