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Results: 1 to 20 of 95

1.

Dichotomy of decorin activity on the insulin-like growth factor-I system.

Morrione A, Neill T, Iozzo RV.

FEBS J. 2013 May;280(10):2138-49. doi: 10.1111/febs.12149. Epub 2013 Feb 15. Review.

PMID:
23351020
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling.

Iozzo RV, Buraschi S, Genua M, Xu SQ, Solomides CC, Peiper SC, Gomella LG, Owens RC, Morrione A.

J Biol Chem. 2011 Oct 7;286(40):34712-21. doi: 10.1074/jbc.M111.262766. Epub 2011 Aug 12.

PMID:
21840990
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.

Burtrum D, Zhu Z, Lu D, Anderson DM, Prewett M, Pereira DS, Bassi R, Abdullah R, Hooper AT, Koo H, Jimenez X, Johnson D, Apblett R, Kussie P, Bohlen P, Witte L, Hicklin DJ, Ludwig DL.

Cancer Res. 2003 Dec 15;63(24):8912-21.

PMID:
14695208
[PubMed - indexed for MEDLINE]
Free Article
4.

Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells.

Ellis MJ, Leav BA, Yang Z, Rasmussen A, Pearce A, Zweibel JA, Lippman ME, Cullen KJ.

Mol Endocrinol. 1996 Mar;10(3):286-97.

PMID:
8833657
[PubMed - indexed for MEDLINE]
5.

Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells.

Genua M, Xu SQ, Buraschi S, Peiper SC, Gomella LG, Belfiore A, Iozzo RV, Morrione A.

PLoS One. 2012;7(6):e40148. doi: 10.1371/journal.pone.0040148. Epub 2012 Jun 28.

PMID:
22859931
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Decorin differentially modulates the activity of insulin receptor isoform A ligands.

Morcavallo A, Buraschi S, Xu SQ, Belfiore A, Schaefer L, Iozzo RV, Morrione A.

Matrix Biol. 2014 Apr;35:82-90. doi: 10.1016/j.matbio.2013.12.010. Epub 2014 Jan 2.

PMID:
24389353
[PubMed - in process]
Free Article
7.

Decorin, a novel player in the insulin-like growth factor system.

Schönherr E, Sunderkötter C, Iozzo RV, Schaefer L.

J Biol Chem. 2005 Apr 22;280(16):15767-72. Epub 2005 Feb 8.

PMID:
15701628
[PubMed - indexed for MEDLINE]
Free Article
8.

The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling.

Li M, Yin Y, Hua H, Sun X, Luo T, Wang J, Jiang Y.

J Biol Chem. 2010 Oct 1;285(40):30480-8. doi: 10.1074/jbc.M110.131698. Epub 2010 Jul 29.

PMID:
20670935
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells.

Yi HK, Kim SY, Hwang PH, Kim CY, Yang DH, Oh Y, Lee DY.

Biochem Biophys Res Commun. 2005 May 13;330(3):760-7.

PMID:
15809062
[PubMed - indexed for MEDLINE]
10.

Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.

Radhakrishnan Y, Busby WH Jr, Shen X, Maile LA, Clemmons DR.

J Biol Chem. 2010 May 21;285(21):15682-95. doi: 10.1074/jbc.M109.092270. Epub 2010 Mar 5.

PMID:
20207740
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Addiction to elevated insulin-like growth factor I receptor and initial modulation of the AKT pathway define the responsiveness of rhabdomyosarcoma to the targeting antibody.

Cao L, Yu Y, Darko I, Currier D, Mayeenuddin LH, Wan X, Khanna C, Helman LJ.

Cancer Res. 2008 Oct 1;68(19):8039-48. doi: 10.1158/0008-5472.CAN-08-1712.

PMID:
18829562
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Dopamine, by acting through its D2 receptor, inhibits insulin-like growth factor-I (IGF-I)-induced gastric cancer cell proliferation via up-regulation of Krüppel-like factor 4 through down-regulation of IGF-IR and AKT phosphorylation.

Ganguly S, Basu B, Shome S, Jadhav T, Roy S, Majumdar J, Dasgupta PS, Basu S.

Am J Pathol. 2010 Dec;177(6):2701-7. doi: 10.2353/ajpath.2010.100617. Epub 2010 Nov 12.

PMID:
21075859
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R.

Molhoek KR, Shada AL, Smolkin M, Chowbina S, Papin J, Brautigan DL, Slingluff CL Jr.

Melanoma Res. 2011 Aug;21(4):274-84. doi: 10.1097/CMR.0b013e328343a1d6.

PMID:
21654344
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells.

Sarfstein R, Pasmanik-Chor M, Yeheskel A, Edry L, Shomron N, Warman N, Wertheimer E, Maor S, Shochat L, Werner H.

J Biol Chem. 2012 Jan 20;287(4):2766-76. doi: 10.1074/jbc.M111.281782. Epub 2011 Nov 29.

PMID:
22128190
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.

El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM.

J Biol Chem. 2007 Sep 7;282(36):26150-7. Epub 2007 Jul 9.

PMID:
17620336
[PubMed - indexed for MEDLINE]
Free Article
16.

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo.

Ji QS, Mulvihill MJ, Rosenfeld-Franklin M, Cooke A, Feng L, Mak G, O'Connor M, Yao Y, Pirritt C, Buck E, Eyzaguirre A, Arnold LD, Gibson NW, Pachter JA.

Mol Cancer Ther. 2007 Aug;6(8):2158-67. Epub 2007 Aug 1.

PMID:
17671083
[PubMed - indexed for MEDLINE]
Free Article
17.

Decorin interferes with platelet-derived growth factor receptor signaling in experimental hepatocarcinogenesis.

Baghy K, Horváth Z, Regős E, Kiss K, Schaff Z, Iozzo RV, Kovalszky I.

FEBS J. 2013 May;280(10):2150-64. doi: 10.1111/febs.12215. Epub 2013 Mar 25.

PMID:
23448253
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Insulin-like growth factor-I E-peptide activity is dependent on the IGF-I receptor.

Brisson BK, Barton ER.

PLoS One. 2012;7(9):e45588. doi: 10.1371/journal.pone.0045588. Epub 2012 Sep 21.

PMID:
23029120
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Leukocyte antigen-related deficiency enhances insulin-like growth factor-1 signaling in vascular smooth muscle cells and promotes neointima formation in response to vascular injury.

Niu XL, Li J, Hakim ZS, Rojas M, Runge MS, Madamanchi NR.

J Biol Chem. 2007 Jul 6;282(27):19808-19. Epub 2007 May 11.

PMID:
17500057
[PubMed - indexed for MEDLINE]
Free Article
20.

Altered expression of insulin-like growth factor I and its receptor during multistage carcinogenesis in mouse skin.

Rho O, Bol DK, You J, Beltrán L, Rupp T, DiGiovanni J.

Mol Carcinog. 1996 Oct;17(2):62-9.

PMID:
8890954
[PubMed - indexed for MEDLINE]

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