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Results: 1 to 20 of 197

1.

Hypoxia increases Aβ-induced tau phosphorylation by calpain and promotes behavioral consequences in AD transgenic mice.

Gao L, Tian S, Gao H, Xu Y.

J Mol Neurosci. 2013 Sep;51(1):138-47. doi: 10.1007/s12031-013-9966-y. Epub 2013 Jan 24.

PMID:
23345083
[PubMed - indexed for MEDLINE]
2.

Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse.

Zhao H, Chang R, Che H, Wang J, Yang L, Fang W, Xia Y, Li N, Ma Q, Wang X.

Neurosci Lett. 2013 Sep 13;551:12-6. doi: 10.1016/j.neulet.2013.06.026. Epub 2013 Jun 25.

PMID:
23810804
[PubMed - indexed for MEDLINE]
3.

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro.

Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y, Zeng J, DelleDonne A, Obregon D, Tan J, Mullan M.

J Neurosci Res. 2002 Aug 1;69(3):362-72.

PMID:
12125077
[PubMed - indexed for MEDLINE]
4.

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.

PMID:
20595388
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD.

Kitazawa M, Cheng D, Laferla FM.

J Neurochem. 2009 Mar;108(6):1550-60. doi: 10.1111/j.1471-4159.2009.05901.x. Epub 2009 Jan 22.

PMID:
19183260
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease.

Wang CY, Xie JW, Wang T, Xu Y, Cai JH, Wang X, Zhao BL, An L, Wang ZY.

CNS Neurosci Ther. 2013 Oct;19(10):820-33. doi: 10.1111/cns.12151. Epub 2013 Jul 27.

PMID:
23889979
[PubMed - indexed for MEDLINE]
7.

Potassium 2-(1-hydroxypentyl)-benzoate improves memory deficits and attenuates amyloid and τ pathologies in a mouse model of Alzheimer's disease.

Peng Y, Hu Y, Xu S, Rong X, Li J, Li P, Wang L, Yang J, Wang X.

J Pharmacol Exp Ther. 2014 Aug;350(2):361-74. doi: 10.1124/jpet.114.213140. Epub 2014 Jun 3.

PMID:
24893984
[PubMed - indexed for MEDLINE]
8.

FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation.

Bao XQ, Li N, Wang T, Kong XC, Tai WJ, Sun H, Zhang D.

PLoS One. 2013 Nov 4;8(11):e78033. doi: 10.1371/journal.pone.0078033. eCollection 2013.

PMID:
24223757
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide.

Seyb KI, Ansar S, Li G, Bean J, Michaelis ML, Dobrowsky RT.

J Mol Neurosci. 2007;31(1):23-35.

PMID:
17416967
[PubMed - indexed for MEDLINE]
10.

L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AβPP/PS1-Alzheimer's transgenic mice.

Peng Y, Hu Y, Xu S, Li P, Li J, Lu L, Yang H, Feng N, Wang L, Wang X.

J Alzheimers Dis. 2012;29(2):379-91. doi: 10.3233/JAD-2011-111577.

PMID:
22233765
[PubMed - indexed for MEDLINE]
11.

Fuzhisan, a Chinese herbal medicine, inhibits beta-amyloid-induced neurotoxicity and tau phosphorylation through calpain/Cdk5 pathway in cultured cortical neurons.

Zhang Z, Zhao R, Tang Y, Wen S, Wang D, Qi J.

Neurochem Res. 2011 May;36(5):801-11. doi: 10.1007/s11064-011-0405-6. Epub 2011 Jan 18. Retraction in: Neurochem Res. 2012 Apr;37(4):902.

PMID:
21243427
[PubMed - indexed for MEDLINE]
12.

Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5.

Lopes JP, Oliveira CR, Agostinho P.

Aging Cell. 2010 Feb;9(1):64-77. doi: 10.1111/j.1474-9726.2009.00536.x. Epub 2009 Nov 6.

PMID:
19895631
[PubMed - indexed for MEDLINE]
Free Article
13.

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

Lopes JP, Oliveira CR, Agostinho P.

Cell Mol Neurobiol. 2007 Nov;27(7):943-57. Epub 2007 Oct 27.

PMID:
17965932
[PubMed - indexed for MEDLINE]
14.

The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo.

Nikkel AL, Martino B, Markosyan S, Brederson JD, Medeiros R, Moeller A, Bitner RS.

Neuropharmacology. 2012 Sep;63(4):606-12. doi: 10.1016/j.neuropharm.2012.05.011. Epub 2012 May 18.

PMID:
22613839
[PubMed - indexed for MEDLINE]
15.

APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.

Barbero-Camps E, Fernández A, Martínez L, Fernández-Checa JC, Colell A.

Hum Mol Genet. 2013 Sep 1;22(17):3460-76. doi: 10.1093/hmg/ddt201. Epub 2013 May 6.

PMID:
23648430
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice.

Liu HL, Zhao G, Zhang H, Shi LD.

Behav Brain Res. 2013 Nov 1;256:261-72. doi: 10.1016/j.bbr.2013.08.008. Epub 2013 Aug 19.

PMID:
23968591
[PubMed - indexed for MEDLINE]
17.

CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice.

Laporte V, Ait-Ghezala G, Volmar CH, Ganey C, Ganey N, Wood M, Mullan M.

Brain Res. 2008 Sep 22;1231:132-42. doi: 10.1016/j.brainres.2008.06.032. Epub 2008 Jun 19.

PMID:
18606155
[PubMed - indexed for MEDLINE]
18.

Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.

Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T.

J Neurosci. 2008 Dec 31;28(53):14511-21. doi: 10.1523/JNEUROSCI.3417-08.2008.

PMID:
19118186
[PubMed - indexed for MEDLINE]
Free Article
19.

Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model.

Ding Y, Qiao A, Wang Z, Goodwin JS, Lee ES, Block ML, Allsbrook M, McDonald MP, Fan GH.

J Neurosci. 2008 Nov 5;28(45):11622-34. doi: 10.1523/JNEUROSCI.3153-08.2008.

PMID:
18987198
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.

Medeiros R, Kitazawa M, Chabrier MA, Cheng D, Baglietto-Vargas D, Kling A, Moeller A, Green KN, LaFerla FM.

Am J Pathol. 2012 Aug;181(2):616-25. doi: 10.1016/j.ajpath.2012.04.020. Epub 2012 Jun 9.

PMID:
22688056
[PubMed - indexed for MEDLINE]
Free Article

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