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Results: 1 to 20 of 100

1.

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.

Whiteman P, de Madrid BH, Taylor P, Li D, Heslop R, Viticheep N, Tan JZ, Shimizu H, Callaghan J, Masiero M, Li JL, Banham AH, Harris AL, Lea SM, Redfield C, Baron M, Handford PA.

J Biol Chem. 2013 Mar 8;288(10):7305-12. doi: 10.1074/jbc.M112.428854. Epub 2013 Jan 21.

PMID:
23339193
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.

Yamamoto S, Charng WL, Rana NA, Kakuda S, Jaiswal M, Bayat V, Xiong B, Zhang K, Sandoval H, David G, Wang H, Haltiwanger RS, Bellen HJ.

Science. 2012 Nov 30;338(6111):1229-32. doi: 10.1126/science.1228745.

PMID:
23197537
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling.

Fleming RJ, Hori K, Sen A, Filloramo GV, Langer JM, Obar RA, Artavanis-Tsakonas S, Maharaj-Best AC.

Development. 2013 May;140(9):2039-49. doi: 10.1242/dev.087916.

PMID:
23571220
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A role of receptor Notch in ligand cis-inhibition in Drosophila.

Becam I, Fiuza UM, Arias AM, Milán M.

Curr Biol. 2010 Mar 23;20(6):554-60. doi: 10.1016/j.cub.2010.01.058. Epub 2010 Mar 11.

PMID:
20226663
[PubMed - indexed for MEDLINE]
Free Article
5.

Structural analysis uncovers lipid-binding properties of Notch ligands.

Chillakuri CR, Sheppard D, Ilagan MX, Holt LR, Abbott F, Liang S, Kopan R, Handford PA, Lea SM.

Cell Rep. 2013 Nov 27;5(4):861-7. doi: 10.1016/j.celrep.2013.10.029. Epub 2013 Nov 14.

PMID:
24239355
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition.

Cordle J, Johnson S, Tay JZ, Roversi P, Wilkin MB, de Madrid BH, Shimizu H, Jensen S, Whiteman P, Jin B, Redfield C, Baron M, Lea SM, Handford PA.

Nat Struct Mol Biol. 2008 Aug;15(8):849-57. doi: 10.1038/nsmb.1457. Epub 2008 Jul 27.

PMID:
18660822
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.

Aste-Amézaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, Thoryk E, Andrawes MB, Tiyanont K, Stegmaier K, Roti G, Ross KN, Franlin LL, Wang H, Wang F, Chastain M, Bett AJ, Audoly LP, Aster JC, Blacklow SC, Huber HE.

PLoS One. 2010 Feb 8;5(2):e9094. doi: 10.1371/journal.pone.0009094.

PMID:
20161710
[PubMed - indexed for MEDLINE]
Free PMC Article
8.
9.

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.

Taylor P, Takeuchi H, Sheppard D, Chillakuri C, Lea SM, Haltiwanger RS, Handford PA.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7290-5. doi: 10.1073/pnas.1319683111. Epub 2014 May 6.

PMID:
24803430
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The EGF-like proteins DLK1 and DLK2 function as inhibitory non-canonical ligands of NOTCH1 receptor that modulate each other's activities.

Sánchez-Solana B, Nueda ML, Ruvira MD, Ruiz-Hidalgo MJ, Monsalve EM, Rivero S, García-Ramírez JJ, Díaz-Guerra MJ, Baladrón V, Laborda J.

Biochim Biophys Acta. 2011 Jun;1813(6):1153-64. doi: 10.1016/j.bbamcr.2011.03.004. Epub 2011 Mar 15.

PMID:
21419176
[PubMed - indexed for MEDLINE]
Free Article
11.

Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC.

J Biol Chem. 2013 Aug 30;288(35):25477-89. doi: 10.1074/jbc.M113.454850. Epub 2013 Jul 9.

PMID:
23839946
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

A Serrate-Notch-Canoe complex mediates essential interactions between glia and neuroepithelial cells during Drosophila optic lobe development.

Pérez-Gómez R, Slováková J, Rives-Quinto N, Krejci A, Carmena A.

J Cell Sci. 2013 Nov 1;126(Pt 21):4873-84. doi: 10.1242/jcs.125617. Epub 2013 Aug 22.

PMID:
23970418
[PubMed - indexed for MEDLINE]
Free Article
13.

In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe.

Xu A, Haines N, Dlugosz M, Rana NA, Takeuchi H, Haltiwanger RS, Irvine KD.

J Biol Chem. 2007 Nov 30;282(48):35153-62. Epub 2007 Oct 8.

PMID:
17923477
[PubMed - indexed for MEDLINE]
Free Article
14.

Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis.

Glittenberg M, Pitsouli C, Garvey C, Delidakis C, Bray S.

EMBO J. 2006 Oct 18;25(20):4697-706. Epub 2006 Sep 28.

PMID:
17006545
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling.

Liu S, Bonner JM, Chanet S, Commisso C, Skwarek LC, Schweisguth F, Boulianne GL.

Mol Cell Biol. 2012 Dec;32(24):4933-45. doi: 10.1128/MCB.00711-12. Epub 2012 Oct 8.

PMID:
23045391
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Antibodies against the extracellular domain of human Notch1 receptor reveal the critical role of epidermal-growth-factor-like repeats 25-26 in ligand binding and receptor activation.

Sharma A, Rangarajan A, Dighe RR.

Biochem J. 2013 Jan 15;449(2):519-30. doi: 10.1042/BJ20121153.

PMID:
23072667
[PubMed - indexed for MEDLINE]
Free Article
17.

Notch signaling in normal and disease States: possible therapies related to glycosylation.

Rampal R, Luther KB, Haltiwanger RS.

Curr Mol Med. 2007 Jun;7(4):427-45.

PMID:
17584081
[PubMed - indexed for MEDLINE]
18.

Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster.

Hamel S, Fantini J, Schweisguth F.

J Cell Biol. 2010 Feb 22;188(4):581-94. doi: 10.1083/jcb.200907116.

PMID:
20176925
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Notch receptor-ligand binding and activation: insights from molecular studies.

Chillakuri CR, Sheppard D, Lea SM, Handford PA.

Semin Cell Dev Biol. 2012 Jun;23(4):421-8. doi: 10.1016/j.semcdb.2012.01.009. Epub 2012 Feb 4. Review.

PMID:
22326375
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Delivering the lateral inhibition punchline: it's all about the timing.

Axelrod JD.

Sci Signal. 2010 Oct 26;3(145):pe38. doi: 10.1126/scisignal.3145pe38. Review.

PMID:
20978236
[PubMed - indexed for MEDLINE]
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