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Items: 1 to 20 of 410

1.

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

Zhou J, Tan SH, Nicolas V, Bauvy C, Yang ND, Zhang J, Xue Y, Codogno P, Shen HM.

Cell Res. 2013 Apr;23(4):508-23. doi: 10.1038/cr.2013.11. Epub 2013 Jan 22.

2.

Dual suppressive effect of MTORC1 on autophagy: tame the dragon by shackling both the head and the tail.

Zhou J, Tan SH, Codogno P, Shen HM.

Autophagy. 2013 May;9(5):803-5. doi: 10.4161/auto.23965. Epub 2013 Feb 25.

3.

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.

Tanaka Y, Matsuwaki T, Yamanouchi K, Nishihara M.

Neuroscience. 2013 Oct 10;250:8-19. doi: 10.1016/j.neuroscience.2013.06.049. Epub 2013 Jul 2.

PMID:
23830905
4.

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy.

Shen HM, Mizushima N.

Trends Biochem Sci. 2014 Feb;39(2):61-71. doi: 10.1016/j.tibs.2013.12.001. Epub 2013 Dec 24. Review.

PMID:
24369758
5.

Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity.

Li M, Khambu B, Zhang H, Kang JH, Chen X, Chen D, Vollmer L, Liu PQ, Vogt A, Yin XM.

J Biol Chem. 2013 Dec 13;288(50):35769-80. doi: 10.1074/jbc.M113.511212. Epub 2013 Oct 30.

6.

TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.

Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z, Wang G.

EMBO J. 2016 Jan 18;35(2):121-42. doi: 10.15252/embj.201591998. Epub 2015 Dec 23.

PMID:
26702100
7.

Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity.

Zha QB, Zhang XY, Lin QR, Xu LH, Zhao GX, Pan H, Zhou D, Ouyang DY, Liu ZH, He XH.

PLoS One. 2015 May 13;10(5):e0124355. doi: 10.1371/journal.pone.0124355. eCollection 2015.

8.

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

Settembre C, Zoncu R, Medina DL, Vetrini F, Erdin S, Erdin S, Huynh T, Ferron M, Karsenty G, Vellard MC, Facchinetti V, Sabatini DM, Ballabio A.

EMBO J. 2012 Mar 7;31(5):1095-108. doi: 10.1038/emboj.2012.32. Epub 2012 Feb 17.

9.

Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death.

Ma X, Godar RJ, Liu H, Diwan A.

Autophagy. 2012 Mar;8(3):297-309. doi: 10.4161/auto.18658. Epub 2012 Feb 3.

10.

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.

Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM.

Sci Signal. 2012 Jun 12;5(228):ra42. doi: 10.1126/scisignal.2002790.

11.

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.

Nezich CL, Wang C, Fogel AI, Youle RJ.

J Cell Biol. 2015 Aug 3;210(3):435-50. doi: 10.1083/jcb.201501002.

12.

TFEB links autophagy to lysosomal biogenesis.

Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A.

Science. 2011 Jun 17;332(6036):1429-33. doi: 10.1126/science.1204592. Epub 2011 May 26.

13.

Lysosomal accumulation of mTOR is enhanced by rapamycin.

Ohsaki Y, Suzuki M, Shinohara Y, Fujimoto T.

Histochem Cell Biol. 2010 Dec;134(6):537-44. doi: 10.1007/s00418-010-0759-x. Epub 2010 Nov 10.

PMID:
21063721
14.

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.

Martina JA, Chen Y, Gucek M, Puertollano R.

Autophagy. 2012 Jun;8(6):903-14. doi: 10.4161/auto.19653. Epub 2012 May 11.

15.

Lysosomal positioning coordinates cellular nutrient responses.

Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC.

Nat Cell Biol. 2011 Apr;13(4):453-60. doi: 10.1038/ncb2204. Epub 2011 Mar 13.

16.

Regulation of TFEB and V-ATPases by mTORC1.

Peña-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, Wolff NC, Tran TA, Zou L, Xie XJ, Corey DR, Brugarolas J.

EMBO J. 2011 Jul 29;30(16):3242-58. doi: 10.1038/emboj.2011.257.

17.

Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion.

Choi YJ, Park YJ, Park JY, Jeong HO, Kim DH, Ha YM, Kim JM, Song YM, Heo HS, Yu BP, Chun P, Moon HR, Chung HY.

PLoS One. 2012;7(8):e43418. doi: 10.1371/journal.pone.0043418. Epub 2012 Aug 22. Erratum in: PLoS One. 2013;8(1). doi:10.1371/annotation/e3163ad5-f3d8-4a21-b3e1-f2033a76f9db.

18.

Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.

Lu Y, Hao BX, Graeff R, Wong CW, Wu WT, Yue J.

J Biol Chem. 2013 Aug 16;288(33):24247-63. doi: 10.1074/jbc.M113.484253. Epub 2013 Jul 8.

19.

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.

Wang W, Gao Q, Yang M, Zhang X, Yu L, Lawas M, Li X, Bryant-Genevier M, Southall NT, Marugan J, Ferrer M, Xu H.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1373-81. doi: 10.1073/pnas.1419669112. Epub 2015 Mar 2.

20.

Autophagy plays a protective role during zVAD-induced necrotic cell death.

Wu YT, Tan HL, Huang Q, Kim YS, Pan N, Ong WY, Liu ZG, Ong CN, Shen HM.

Autophagy. 2008 May;4(4):457-66. Epub 2008 Feb 1.

PMID:
18253089
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