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Sex differences in the antidepressant-like effects of ketamine.

Carrier N, Kabbaj M.

Neuropharmacology. 2013 Jul;70:27-34. doi: 10.1016/j.neuropharm.2012.12.009. Epub 2013 Jan 19.


A review of ketamine in affective disorders: current evidence of clinical efficacy, limitations of use and pre-clinical evidence on proposed mechanisms of action.

Naughton M, Clarke G, O'Leary OF, Cryan JF, Dinan TG.

J Affect Disord. 2014 Mar;156:24-35. doi: 10.1016/j.jad.2013.11.014. Epub 2013 Dec 10. Review.


Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex.

Zhou W, Wang N, Yang C, Li XM, Zhou ZQ, Yang JJ.

Eur Psychiatry. 2014 Sep;29(7):419-23. doi: 10.1016/j.eurpsy.2013.10.005. Epub 2013 Dec 8.


Tramadol pretreatment enhances ketamine-induced antidepressant effects and increases mammalian target of rapamycin in rat hippocampus and prefrontal cortex.

Yang C, Li WY, Yu HY, Gao ZQ, Liu XL, Zhou ZQ, Yang JJ.

J Biomed Biotechnol. 2012;2012:175619. doi: 10.1155/2012/175619. Epub 2012 Apr 8.


The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress.

Chiu CT, Scheuing L, Liu G, Liao HM, Linares GR, Lin D, Chuang DM.

Int J Neuropsychopharmacol. 2014 Dec 28;18(6). pii: pyu102. doi: 10.1093/ijnp/pyu102.


GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine.

Liu RJ, Fuchikami M, Dwyer JM, Lepack AE, Duman RS, Aghajanian GK.

Neuropsychopharmacology. 2013 Oct;38(11):2268-77. doi: 10.1038/npp.2013.128. Epub 2013 May 17.


Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds.

Niciu MJ, Henter ID, Luckenbaugh DA, Zarate CA Jr, Charney DS.

Annu Rev Pharmacol Toxicol. 2014;54:119-39. doi: 10.1146/annurev-pharmtox-011613-135950. Review.


NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.

Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF, Kavalali ET, Monteggia LM.

Nature. 2011 Jun 15;475(7354):91-5. doi: 10.1038/nature10130.


Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models.

Engin E, Treit D, Dickson CT.

Neuroscience. 2009 Jun 30;161(2):359-69. doi: 10.1016/j.neuroscience.2009.03.038. Epub 2009 Mar 24. Erratum in: Neuroscience. 2009 Sep 15;162(4):1438-9.


The role of eukaryotic elongation factor 2 kinase in rapid antidepressant action of ketamine.

Monteggia LM, Gideons E, Kavalali ET.

Biol Psychiatry. 2013 Jun 15;73(12):1199-203. doi: 10.1016/j.biopsych.2012.09.006. Epub 2012 Oct 11. Review.


Antidepressant-like cognitive and behavioral effects of acute ketamine administration associated with plasticity in the ventral hippocampus to medial prefrontal cortex pathway.

Jett JD, Boley AM, Girotti M, Shah A, Lodge DJ, Morilak DA.

Psychopharmacology (Berl). 2015 Sep;232(17):3123-33. doi: 10.1007/s00213-015-3957-3. Epub 2015 May 20.


Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and "depressed" mice exposed to chronic mild stress.

Franceschelli A, Sens J, Herchick S, Thelen C, Pitychoutis PM.

Neuroscience. 2015 Apr 2;290:49-60. doi: 10.1016/j.neuroscience.2015.01.008. Epub 2015 Jan 14.


Antidepressant effects of AMPA and ketamine combination: role of hippocampal BDNF, synapsin, and mTOR.

Akinfiresoye L, Tizabi Y.

Psychopharmacology (Berl). 2013 Nov;230(2):291-8. doi: 10.1007/s00213-013-3153-2. Epub 2013 Jun 4.


Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats.

Zhu WL, Wang SJ, Liu MM, Shi HS, Zhang RX, Liu JF, Ding ZB, Lu L.

J Psychiatry Neurosci. 2013 Sep;38(5):306-16. doi: 10.1503/jpn.120228.


The role of mTOR in depression and antidepressant responses.

Abelaira HM, Réus GZ, Neotti MV, Quevedo J.

Life Sci. 2014 Apr 17;101(1-2):10-4. doi: 10.1016/j.lfs.2014.02.014. Epub 2014 Feb 25. Review.


mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists.

Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS.

Science. 2010 Aug 20;329(5994):959-64. doi: 10.1126/science.1190287.


Antidepressant-like effects of low ketamine dose is associated with increased hippocampal AMPA/NMDA receptor density ratio in female Wistar-Kyoto rats.

Tizabi Y, Bhatti BH, Manaye KF, Das JR, Akinfiresoye L.

Neuroscience. 2012 Jun 28;213:72-80. doi: 10.1016/j.neuroscience.2012.03.052. Epub 2012 Apr 19.


Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses.

Gideons ES, Kavalali ET, Monteggia LM.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8649-54. doi: 10.1073/pnas.1323920111. Epub 2014 May 27.


Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract.

Shin IJ, Son SU, Park H, Kim Y, Park SH, Swanberg K, Shin JY, Ha SK, Cho Y, Bang SY, Lew JH, Cho SH, Maeng S.

PLoS One. 2014 Feb 10;9(2):e88617. doi: 10.1371/journal.pone.0088617. eCollection 2014.


Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain.

Réus GZ, Stringari RB, Ribeiro KF, Ferraro AK, Vitto MF, Cesconetto P, Souza CT, Quevedo J.

Behav Brain Res. 2011 Aug 1;221(1):166-71. doi: 10.1016/j.bbr.2011.02.024. Epub 2011 Mar 21.

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