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Items: 1 to 20 of 134


A noncatalytic function of the ligation complex during nonhomologous end joining.

Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P.

J Cell Biol. 2013 Jan 21;200(2):173-86. doi: 10.1083/jcb.201203128.


Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

Wu PY, Frit P, Malivert L, Revy P, Biard D, Salles B, Calsou P.

J Biol Chem. 2007 Nov 2;282(44):31937-43. Epub 2007 Aug 24.


DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

Zhou Y, Paull TT.

J Biol Chem. 2013 Dec 27;288(52):37112-25. doi: 10.1074/jbc.M113.514398. Epub 2013 Nov 12.


Analysis of DNA-dependent protein kinase-mediated DNA end joining by two-photon fluorescence cross-correlation spectroscopy.

Merkle D, Block WD, Yu Y, Lees-Miller SP, Cramb DT.

Biochemistry. 2006 Apr 4;45(13):4164-72.


Biochemical evidence for Ku-independent backup pathways of NHEJ.

Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G.

Nucleic Acids Res. 2003 Sep 15;31(18):5377-88.


The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.

Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP.

Biochemistry. 2002 Oct 22;41(42):12706-14.


Role and regulation of human XRCC4-like factor/cernunnos.

Dahm K.

J Cell Biochem. 2008 Aug 1;104(5):1534-40. doi: 10.1002/jcb.21726. Review.


Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends.

Drouet J, Frit P, Delteil C, de Villartay JP, Salles B, Calsou P.

J Biol Chem. 2006 Sep 22;281(38):27784-93. Epub 2006 Jul 19.


The spatial organization of non-homologous end joining: from bridging to end joining.

Ochi T, Wu Q, Blundell TL.

DNA Repair (Amst). 2014 May;17:98-109. doi: 10.1016/j.dnarep.2014.02.010. Epub 2014 Mar 11.


Cooperative assembly of a protein-DNA filament for nonhomologous end joining.

Tsai CJ, Chu G.

J Biol Chem. 2013 Jun 21;288(25):18110-20. doi: 10.1074/jbc.M113.464115. Epub 2013 Apr 25.


Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.

Chen L, Trujillo K, Sung P, Tomkinson AE.

J Biol Chem. 2000 Aug 25;275(34):26196-205.


Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.

Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2234-9. doi: 10.1073/pnas.1222573110. Epub 2013 Jan 23.


XRCC4's interaction with XLF is required for coding (but not signal) end joining.

Roy S, Andres SN, Vergnes A, Neal JA, Xu Y, Yu Y, Lees-Miller SP, Junop M, Modesti M, Meek K.

Nucleic Acids Res. 2012 Feb;40(4):1684-94. doi: 10.1093/nar/gkr1315. Epub 2012 Jan 6.


Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.

Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA.

J Biol Chem. 2004 Sep 17;279(38):39408-13. Epub 2004 Jul 15.


Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends.

Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, Lees-Miller SP.

Nucleic Acids Res. 2004 Aug 16;32(14):4351-7. Print 2004.


C-Terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin.

Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):173-8. doi: 10.1016/j.bbrc.2013.08.068. Epub 2013 Aug 28.


XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.

Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP.

Biochem Cell Biol. 2013 Feb;91(1):31-41. doi: 10.1139/bcb-2012-0058. Epub 2013 Feb 5. Review.

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