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Targets of vascular protection in acute ischemic stroke differ in type 2 diabetes.

Kelly-Cobbs AI, Prakash R, Li W, Pillai B, Hafez S, Coucha M, Johnson MH, Ogbi SN, Fagan SC, Ergul A.

Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H806-15. doi: 10.1152/ajpheart.00720.2012. Epub 2013 Jan 18.


Minocycline and hypothermia for reperfusion injury after focal cerebral ischemia in the rat: effects on BBB breakdown and MMP expression in the acute and subacute phase.

Nagel S, Su Y, Horstmann S, Heiland S, Gardner H, Koziol J, Martinez-Torres FJ, Wagner S.

Brain Res. 2008 Jan 10;1188:198-206. Epub 2007 Nov 26.


Enhancement of matrix metalloproteinase 2 and 9 inhibitory action of minocycline by aspirin: an approach to attenuate outcome of acute myocardial infarction in diabetes.

Bhatt LK, Veeranjaneyulu A.

Arch Med Res. 2014 Apr;45(3):203-9. doi: 10.1016/j.arcmed.2014.01.008. Epub 2014 Mar 4.


Extension of the thrombolytic time window with minocycline in experimental stroke.

Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH.

Stroke. 2008 Dec;39(12):3372-7. doi: 10.1161/STROKEAHA.108.514026. Epub 2008 Oct 16.


Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats.

Thiyagarajan M, Kaul CL, Sharma SS.

Br J Pharmacol. 2004 Jul;142(5):899-911. Epub 2004 Jun 14.


Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats.

Fan X, Lo EH, Wang X.

Stroke. 2013 Mar;44(3):745-52. doi: 10.1161/STROKEAHA.111.000309. Epub 2013 Feb 19.


Delayed minocycline inhibits ischemia-activated matrix metalloproteinases 2 and 9 after experimental stroke.

Machado LS, Kozak A, Ergul A, Hess DC, Borlongan CV, Fagan SC.

BMC Neurosci. 2006 Jul 17;7:56.


Drug repurposing for vascular protection after acute ischemic stroke.

Guan W, Kozak A, Fagan SC.

Acta Neurochir Suppl. 2011;111:295-8. doi: 10.1007/978-3-7091-0693-8_49.


Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential.

Machado LS, Sazonova IY, Kozak A, Wiley DC, El-Remessy AB, Ergul A, Hess DC, Waller JL, Fagan SC.

Stroke. 2009 Sep;40(9):3028-33. doi: 10.1161/STROKEAHA.109.556852. Epub 2009 Jul 23.


Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats.

Li W, Qu Z, Prakash R, Chung C, Ma H, Hoda MN, Fagan SC, Ergul A.

Brain Res. 2013 Dec 6;1541:106-14. doi: 10.1016/j.brainres.2013.10.021. Epub 2013 Oct 19.


Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

Yagi K, Kitazato KT, Uno M, Tada Y, Kinouchi T, Shimada K, Nagahiro S.

Stroke. 2009 Feb;40(2):626-31. doi: 10.1161/STROKEAHA.108.520262. Epub 2008 Dec 18.


Potentiation of aspirin-induced cerebroprotection by minocycline: a therapeutic approach to attenuate exacerbation of transient focal cerebral ischaemia.

Bhatt LK, Addepalli V.

Diab Vasc Dis Res. 2012 Jan;9(1):25-34. doi: 10.1177/1479164111427753. Epub 2011 Nov 1.


Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats.

Tsubokawa T, Solaroglu I, Yatsushige H, Cahill J, Yata K, Zhang JH.

Stroke. 2006 Jul;37(7):1888-94. Epub 2006 Jun 8.


Increased hemorrhagic transformation and altered infarct size and localization after experimental stroke in a rat model type 2 diabetes.

Ergul A, Elgebaly MM, Middlemore ML, Li W, Elewa H, Switzer JA, Hall C, Kozak A, Fagan SC.

BMC Neurol. 2007 Oct 15;7:33.


Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat.

Dohare P, Garg P, Jain V, Nath C, Ray M.

Behav Brain Res. 2008 Nov 21;193(2):289-97. doi: 10.1016/j.bbr.2008.06.012. Epub 2008 Jun 19.


Low dose intravenous minocycline is neuroprotective after middle cerebral artery occlusion-reperfusion in rats.

Xu L, Fagan SC, Waller JL, Edwards D, Borlongan CV, Zheng J, Hill WD, Feuerstein G, Hess DC.

BMC Neurol. 2004 Apr 26;4:7.


Peroxynitrite decomposition catalyst prevents matrix metalloproteinase activation and neurovascular injury after prolonged cerebral ischemia in rats.

Suofu Y, Clark J, Broderick J, Wagner KR, Tomsick T, Sa Y, Lu A.

J Neurochem. 2010 Dec;115(5):1266-76. doi: 10.1111/j.1471-4159.2010.07026.x. Epub 2010 Oct 26.


Neuroprotective effect of bicyclol in rat ischemic stroke: down-regulates TLR4, TLR9, TRAF6, NF-κB, MMP-9 and up-regulates claudin-5 expression.

Zhang J, Fu B, Zhang X, Chen L, Zhang L, Zhao X, Bai X, Zhu C, Cui L, Wang L.

Brain Res. 2013 Aug 28;1528:80-8. doi: 10.1016/j.brainres.2013.06.032. Epub 2013 Jul 10.

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