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Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enteroviruses B and D by targeting viral protein 2C.

Ulferts R, van der Linden L, Thibaut HJ, Lanke KH, Leyssen P, Coutard B, De Palma AM, Canard B, Neyts J, van Kuppeveld FJ.

Antimicrob Agents Chemother. 2013 Apr;57(4):1952-6. doi: 10.1128/AAC.02084-12. Epub 2013 Jan 18.


The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C.

De Palma AM, Heggermont W, Lanke K, Coutard B, Bergmann M, Monforte AM, Canard B, De Clercq E, Chimirri A, Pürstinger G, Rohayem J, van Kuppeveld F, Neyts J.

J Virol. 2008 May;82(10):4720-30. doi: 10.1128/JVI.01338-07. Epub 2008 Mar 12.


Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307.

De Palma AM, Thibaut HJ, van der Linden L, Lanke K, Heggermont W, Ireland S, Andrews R, Arimilli M, Al-Tel TH, De Clercq E, van Kuppeveld F, Neyts J.

Antimicrob Agents Chemother. 2009 May;53(5):1850-7. doi: 10.1128/AAC.00934-08. Epub 2009 Feb 23.


Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication.

Tang WF, Yang SY, Wu BW, Jheng JR, Chen YL, Shih CH, Lin KH, Lai HC, Tang P, Horng JT.

J Biol Chem. 2007 Feb 23;282(8):5888-98. Epub 2006 Dec 20.


Recombinant lentivirus-delivered short hairpin RNAs targeted to conserved coxsackievirus sequences protect against viral myocarditis and improve survival rate in an animal model.

Kim YJ, Ahn J, Jeung SY, Kim DS, Na HN, Cho YJ, Yun SH, Jee Y, Jeon ES, Lee H, Nam JH.

Virus Genes. 2008 Feb;36(1):141-6. doi: 10.1007/s11262-007-0192-y. Epub 2008 Jan 3.


Enterovirus 94, a proposed new serotype in human enterovirus species D.

Smura TP, Junttila N, Blomqvist S, Norder H, Kaijalainen S, Paananen A, Magnius LO, Hovi T, Roivainen M.

J Gen Virol. 2007 Mar;88(Pt 3):849-58.


Direct interaction between two viral proteins, the nonstructural protein 2C and the capsid protein VP3, is required for enterovirus morphogenesis.

Liu Y, Wang C, Mueller S, Paul AV, Wimmer E, Jiang P.

PLoS Pathog. 2010 Aug 26;6(8):e1001066. doi: 10.1371/journal.ppat.1001066.


MiR-342-5p suppresses coxsackievirus B3 biosynthesis by targeting the 2C-coding region.

Wang L, Qin Y, Tong L, Wu S, Wang Q, Jiao Q, Guo Z, Lin L, Wang R, Zhao W, Zhong Z.

Antiviral Res. 2012 Feb;93(2):270-9. doi: 10.1016/j.antiviral.2011.12.004. Epub 2011 Dec 13.


Fluoxetine is a potent inhibitor of coxsackievirus replication.

Zuo J, Quinn KK, Kye S, Cooper P, Damoiseaux R, Krogstad P.

Antimicrob Agents Chemother. 2012 Sep;56(9):4838-44. doi: 10.1128/AAC.00983-12. Epub 2012 Jul 2.


COPI is required for enterovirus 71 replication.

Wang J, Wu Z, Jin Q.

PLoS One. 2012;7(5):e38035. doi: 10.1371/journal.pone.0038035. Epub 2012 May 25.


Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine.

Owens MJ, Knight DL, Nemeroff CB.

Biol Psychiatry. 2001 Sep 1;50(5):345-50.


Prozac: panacea or puzzle?

Stanford SC.

Trends Pharmacol Sci. 1996 Apr;17(4):150-4. Review.


Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac).

Ni YG, Miledi R.

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2036-40.


Recombination in circulating Human enterovirus B: independent evolution of structural and non-structural genome regions.

Lukashev AN, Lashkevich VA, Ivanova OE, Koroleva GA, Hinkkanen AE, Ilonen J.

J Gen Virol. 2005 Dec;86(Pt 12):3281-90.


Regulation of poliovirus 3C protease by the 2C polypeptide.

Banerjee R, Weidman MK, Echeverri A, Kundu P, Dasgupta A.

J Virol. 2004 Sep;78(17):9243-56.


Fluoxetine (prozac) and serotonin act on excitatory synaptic transmission to suppress single layer 2/3 pyramidal neuron-triggered cell assemblies in the human prefrontal cortex.

Komlósi G, Molnár G, Rózsa M, Oláh S, Barzó P, Tamás G.

J Neurosci. 2012 Nov 14;32(46):16369-78. doi: 10.1523/JNEUROSCI.2618-12.2012.


Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain.

Di Benedetto M, D'Addario C, Collins S, Izenwasser S, Candeletti S, Romualdi P.

J Mol Neurosci. 2004;22(3):213-22.


Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation.

Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H.

J Immunol. 2011 Sep 1;187(5):2202-12. doi: 10.4049/jimmunol.1100285. Epub 2011 Aug 1.

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