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Results: 1 to 20 of 96

1.

Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx.

Ngok SP, Geyer R, Kourtidis A, Storz P, Anastasiadis PZ.

J Biol Chem. 2013 Mar 1;288(9):6640-50. doi: 10.1074/jbc.M112.432682. Epub 2013 Jan 18.

PMID:
23335514
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.

Ngok SP, Geyer R, Liu M, Kourtidis A, Agrawal S, Wu C, Seerapu HR, Lewis-Tuffin LJ, Moodie KL, Huveldt D, Marx R, Baraban JM, Storz P, Horowitz A, Anastasiadis PZ.

J Cell Biol. 2012 Dec 24;199(7):1103-15. doi: 10.1083/jcb.201207009. Epub 2012 Dec 17.

PMID:
23253477
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration.

Dachsel JC, Ngok SP, Lewis-Tuffin LJ, Kourtidis A, Geyer R, Johnston L, Feathers R, Anastasiadis PZ.

Mol Cell Biol. 2013 Dec;33(24):4909-18. doi: 10.1128/MCB.00565-13. Epub 2013 Oct 14.

PMID:
24126053
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.

Goh LL, Manser E.

PLoS One. 2010 Aug 25;5(8):e12409. doi: 10.1371/journal.pone.0012409.

PMID:
20811643
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding.

Chahdi A, Sorokin A.

Mol Cell Biol. 2008 Mar;28(5):1679-87. Epub 2007 Dec 26.

PMID:
18160719
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization.

Yamahashi Y, Saito Y, Murata-Kamiya N, Hatakeyama M.

J Biol Chem. 2011 Dec 30;286(52):44576-84. doi: 10.1074/jbc.M111.267021. Epub 2011 Nov 9.

PMID:
22072711
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.

Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L.

Blood. 2009 Jan 1;113(1):244-53. doi: 10.1182/blood-2008-04-153874. Epub 2008 Sep 29.

PMID:
18824598
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function.

Ngok SP, Geyer R, Kourtidis A, Mitin N, Feathers R, Der C, Anastasiadis PZ.

J Cell Sci. 2013 Aug 1;126(Pt 15):3271-7. doi: 10.1242/jcs.123869. Epub 2013 May 31.

PMID:
23729734
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition.

Aijaz S, D'Atri F, Citi S, Balda MS, Matter K.

Dev Cell. 2005 May;8(5):777-86.

PMID:
15866167
[PubMed - indexed for MEDLINE]
Free Article
11.

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.

Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM.

J Biol Chem. 2004 Apr 30;279(18):18392-400. Epub 2004 Feb 17.

PMID:
14970201
[PubMed - indexed for MEDLINE]
Free Article
12.

Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo.

Garnaas MK, Moodie KL, Liu ML, Samant GV, Li K, Marx R, Baraban JM, Horowitz A, Ramchandran R.

Circ Res. 2008 Sep 26;103(7):710-6. doi: 10.1161/CIRCRESAHA.108.181388. Epub 2008 Aug 28.

PMID:
18757825
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The GTPase-deficient Rnd proteins are stabilized by their effectors.

Goh LL, Manser E.

J Biol Chem. 2012 Sep 7;287(37):31311-20. doi: 10.1074/jbc.M111.327056. Epub 2012 Jul 17.

PMID:
22807448
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (β-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction.

Valdes JL, Tang J, McDermott MI, Kuo JC, Zimmerman SP, Wincovitch SM, Waterman CM, Milgram SL, Playford MP.

J Biol Chem. 2011 Nov 11;286(45):39403-16. doi: 10.1074/jbc.M111.260802. Epub 2011 Sep 18.

PMID:
21926430
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.

Wu C, Agrawal S, Vasanji A, Drazba J, Sarkaria S, Xie J, Welch CM, Liu M, Anand-Apte B, Horowitz A.

J Biol Chem. 2011 Jul 1;286(26):23511-20. doi: 10.1074/jbc.M111.245209. Epub 2011 May 4.

PMID:
21543326
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

PAK1 negatively regulates the activity of the Rho exchange factor NET1.

Alberts AS, Qin H, Carr HS, Frost JA.

J Biol Chem. 2005 Apr 1;280(13):12152-61. Epub 2005 Jan 31.

PMID:
15684429
[PubMed - indexed for MEDLINE]
Free Article
17.

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R.

Genes Dev. 2007 Jun 15;21(12):1478-83.

PMID:
17575049
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells.

Ogita H, Kunimoto S, Kamioka Y, Sawa H, Masuda M, Mochizuki N.

Circ Res. 2003 Jul 11;93(1):23-31. Epub 2003 May 29.

PMID:
12775584
[PubMed - indexed for MEDLINE]
Free Article
19.

The Rho family guanine nucleotide exchange factor Vav-2 regulates the development of cell-mediated cytotoxicity.

Billadeau DD, Mackie SM, Schoon RA, Leibson PJ.

J Exp Med. 2000 Aug 7;192(3):381-92.

PMID:
10934226
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

Nalbant P, Chang YC, Birkenfeld J, Chang ZF, Bokoch GM.

Mol Biol Cell. 2009 Sep;20(18):4070-82. doi: 10.1091/mbc.E09-01-0041. Epub 2009 Jul 22.

PMID:
19625450
[PubMed - indexed for MEDLINE]
Free PMC Article

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