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Items: 1 to 20 of 153


Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice.

Khan OM, Akula MK, Skålen K, Karlsson C, Ståhlman M, Young SG, Borén J, Bergo MO.

Circulation. 2013 Feb 19;127(7):782-90. doi: 10.1161/CIRCULATIONAHA.112.000588. Epub 2013 Jan 18.


Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.

Zhou Q, Mei Y, Shoji T, Han X, Kaminski K, Oh GT, Ongusaha PP, Zhang K, Schmitt H, Moser M, Bode C, Liao JK.

Circulation. 2012 Oct 30;126(18):2236-47. doi: 10.1161/CIRCULATIONAHA.111.086041. Epub 2012 Sep 25.


CD36-mediated cholesterol efflux is associated with PPARgamma activation via a MAPK-dependent COX-2 pathway in macrophages.

Bujold K, Rhainds D, Jossart C, Febbraio M, Marleau S, Ong H.

Cardiovasc Res. 2009 Aug 1;83(3):457-64. doi: 10.1093/cvr/cvp118. Epub 2009 Apr 17.


Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice.

Khan OM, Ibrahim MX, Jonsson IM, Karlsson C, Liu M, Sjogren AK, Olofsson FJ, Brisslert M, Andersson S, Ohlsson C, Hultén LM, Bokarewa M, Bergo MO.

J Clin Invest. 2011 Feb;121(2):628-39. doi: 10.1172/JCI43758. Epub 2011 Jan 25.


EP 80317, a ligand of the CD36 scavenger receptor, protects apolipoprotein E-deficient mice from developing atherosclerotic lesions.

Marleau S, Harb D, Bujold K, Avallone R, Iken K, Wang Y, Demers A, Sirois MG, Febbraio M, Silverstein RL, Tremblay A, Ong H.

FASEB J. 2005 Nov;19(13):1869-71. Epub 2005 Aug 25.


Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice.

Zhang W, Yancey PG, Su YR, Babaev VR, Zhang Y, Fazio S, Linton MF.

Circulation. 2003 Nov 4;108(18):2258-63. Epub 2003 Oct 27.


Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF.

Circulation. 2007 Sep 18;116(12):1404-12. Epub 2007 Aug 27.


Adipocyte enhancer-binding protein 1 (AEBP1) (a novel macrophage proinflammatory mediator) overexpression promotes and ablation attenuates atherosclerosis in ApoE (-/-) and LDLR (-/-) mice.

Bogachev O, Majdalawieh A, Pan X, Zhang L, Ro HS.

Mol Med. 2011 Sep-Oct;17(9-10):1056-64. doi: 10.2119/molmed.2011.00141. Epub 2011 Jun 14.


GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient mice.

Ditiatkovski M, Toh BH, Bobik A.

Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2337-44. Epub 2006 Jul 27.


Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma.

Li AC, Binder CJ, Gutierrez A, Brown KK, Plotkin CR, Pattison JW, Valledor AF, Davis RA, Willson TM, Witztum JL, Palinski W, Glass CK.

J Clin Invest. 2004 Dec;114(11):1564-76.


Potential beneficial effects of ixmyelocel-T in the treatment of atherosclerotic diseases.

Ledford KJ, Murphy N, Zeigler F, Bartel RL.

Stem Cell Res Ther. 2013 Nov 1;4(6):135. doi: 10.1186/scrt346.


Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway.

Xia M, Hou M, Zhu H, Ma J, Tang Z, Wang Q, Li Y, Chi D, Yu X, Zhao T, Han P, Xia X, Ling W.

J Biol Chem. 2005 Nov 4;280(44):36792-801. Epub 2005 Aug 17.


Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

Argmann CA, Edwards JY, Sawyez CG, O'Neil CH, Hegele RA, Pickering JG, Huff MW.

J Biol Chem. 2005 Jun 10;280(23):22212-21. Epub 2005 Apr 6.


Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet.

Song G, Liu J, Zhao Z, Yu Y, Tian H, Yao S, Li G, Qin S.

Lipids Health Dis. 2011 Jan 18;10:8. doi: 10.1186/1476-511X-10-8.


Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-γ in apolipoprotein E-Null mice.

Pendse AA, Johnson LA, Kim HS, McNair M, Nipp CT, Wilhelm C, Maeda N.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1436-44. doi: 10.1161/ATVBAHA.112.248682. Epub 2012 Apr 26.


The role of the scavenger receptor CD36 in regulating mononuclear phagocyte trafficking to atherosclerotic lesions and vascular inflammation.

Harb D, Bujold K, Febbraio M, Sirois MG, Ong H, Marleau S.

Cardiovasc Res. 2009 Jul 1;83(1):42-51. doi: 10.1093/cvr/cvp081. Epub 2009 Mar 5.


IL-33 reduces macrophage foam cell formation.

McLaren JE, Michael DR, Salter RC, Ashlin TG, Calder CJ, Miller AM, Liew FY, Ramji DP.

J Immunol. 2010 Jul 15;185(2):1222-9. doi: 10.4049/jimmunol.1000520. Epub 2010 Jun 11.


Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis.

Paul A, Chang BH, Li L, Yechoor VK, Chan L.

Circ Res. 2008 Jun 20;102(12):1492-501. doi: 10.1161/CIRCRESAHA.107.168070. Epub 2008 May 15.


Adenosine monophosphate-activated protein kinase induces cholesterol efflux from macrophage-derived foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.

Li D, Wang D, Wang Y, Ling W, Feng X, Xia M.

J Biol Chem. 2010 Oct 22;285(43):33499-509. doi: 10.1074/jbc.M110.159772. Epub 2010 Aug 16.

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