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Items: 1 to 20 of 116


Sensing the immune microenvironment to coordinate T cell metabolism, differentiation & function.

Heikamp EB, Powell JD.

Semin Immunol. 2012 Dec;24(6):414-20. doi: 10.1016/j.smim.2012.12.003. Epub 2013 Jan 14. Review.


Regulation of immune responses by mTOR.

Powell JD, Pollizzi KN, Heikamp EB, Horton MR.

Annu Rev Immunol. 2012;30:39-68. doi: 10.1146/annurev-immunol-020711-075024. Epub 2011 Nov 29. Review.


mTOR, metabolism, and the regulation of T-cell differentiation and function.

Waickman AT, Powell JD.

Immunol Rev. 2012 Sep;249(1):43-58. doi: 10.1111/j.1600-065X.2012.01152.x. Review.


mTOR signalling and metabolic regulation of T cell differentiation.

Peter C, Waldmann H, Cobbold SP.

Curr Opin Immunol. 2010 Oct;22(5):655-61. doi: 10.1016/j.coi.2010.08.010. Epub 2010 Sep 15. Review.


Regulation of T cells by mTOR: the known knowns and the known unknowns.

Pollizzi KN, Powell JD.

Trends Immunol. 2015 Jan;36(1):13-20. doi: 10.1016/ Epub 2014 Dec 16. Review.


mTOR, linking metabolism and immunity.

Xu X, Ye L, Araki K, Ahmed R.

Semin Immunol. 2012 Dec;24(6):429-35. doi: 10.1016/j.smim.2012.12.005. Epub 2013 Jan 24. Review.


The role and regulation of mTOR in T-lymphocyte function.

O'Brien TF, Zhong XP.

Arch Immunol Ther Exp (Warsz). 2012 Jun;60(3):173-81. doi: 10.1007/s00005-012-0171-4. Epub 2012 Apr 8. Review.


Regulation and function of mTOR signalling in T cell fate decisions.

Chi H.

Nat Rev Immunol. 2012 Apr 20;12(5):325-38. doi: 10.1038/nri3198. Review.


mTOR regulates T-cell differentiation and activation in immunity and autoimmunity.

Bi Y, Liu G, Yang R.

Crit Rev Eukaryot Gene Expr. 2011;21(4):313-22. Review.


mTOR and metabolic pathways in T cell quiescence and functional activation.

Yang K, Chi H.

Semin Immunol. 2012 Dec;24(6):421-8. doi: 10.1016/j.smim.2012.12.004. Epub 2013 Feb 1. Review.


The liver kinase B1 is a central regulator of T cell development, activation, and metabolism.

MacIver NJ, Blagih J, Saucillo DC, Tonelli L, Griss T, Rathmell JC, Jones RG.

J Immunol. 2011 Oct 15;187(8):4187-98. doi: 10.4049/jimmunol.1100367. Epub 2011 Sep 19.


The mTOR pathway and integrating immune regulation.

Cobbold SP.

Immunology. 2013 Dec;140(4):391-8. doi: 10.1111/imm.12162. Review.


mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.

Ito D, Nojima S, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A.

J Immunol. 2015 Aug 1;195(3):934-43. doi: 10.4049/jimmunol.1403038. Epub 2015 Jun 26.


A modified model of T-cell differentiation based on mTOR activity and metabolism.

Powell JD, Heikamp EB, Pollizzi KN, Waickman AT.

Cold Spring Harb Symp Quant Biol. 2013;78:125-30. doi: 10.1101/sqb.2013.78.020214. Epub 2013 Oct 7.


Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection.

Lo YC, Lee CF, Powell JD.

Curr Opin Organ Transplant. 2014 Aug;19(4):363-71. doi: 10.1097/MOT.0000000000000098. Review.


mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases.

Pierdominici M, Vacirca D, Delunardo F, Ortona E.

Curr Pharm Des. 2011 Dec;17(35):3888-97. Review.


Serine-threonine kinases in TCR signaling.

Navarro MN, Cantrell DA.

Nat Immunol. 2014 Sep;15(9):808-14. doi: 10.1038/ni.2941. Review.


The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism.

Powell JD, Delgoffe GM.

Immunity. 2010 Sep 24;33(3):301-11. doi: 10.1016/j.immuni.2010.09.002. Review.


mTOR and its tight regulation for iNKT cell development and effector function.

Yang W, Gorentla B, Zhong XP, Shin J.

Mol Immunol. 2015 Dec;68(2 Pt C):536-45. doi: 10.1016/j.molimm.2015.07.022. Epub 2015 Aug 4. Review.


T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming.

Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H.

Immunity. 2013 Dec 12;39(6):1043-56. doi: 10.1016/j.immuni.2013.09.015. Epub 2013 Dec 5.

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