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Results: 1 to 20 of 136

1.

Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.

Sun H, Zhu L, Yang H, Qian W, Guo L, Zhou S, Gao B, Li Z, Zhou Y, Jiang H, Chen K, Zhen X, Liu H.

Bioorg Med Chem. 2013 Feb 15;21(4):856-68. doi: 10.1016/j.bmc.2012.12.016. Epub 2012 Dec 21.

PMID:
23332346
[PubMed - indexed for MEDLINE]
2.

New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.

Liégeois JF, Deville M, Dilly S, Lamy C, Mangin F, Résimont M, Tarazi FI.

J Med Chem. 2012 Feb 23;55(4):1572-82. doi: 10.1021/jm2013419. Epub 2012 Feb 13.

PMID:
22268448
[PubMed - indexed for MEDLINE]
3.

Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D₁ receptor.

Qian W, Lu W, Sun H, Li Z, Zhu L, Zhao R, Zhang L, Zhou S, Zhou Y, Jiang H, Zhen X, Liu H.

Bioorg Med Chem. 2012 Aug 1;20(15):4862-71. doi: 10.1016/j.bmc.2012.05.057. Epub 2012 Jun 5.

PMID:
22748706
[PubMed - indexed for MEDLINE]
4.

Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies.

Stark AD, Jordan S, Allers KA, Bertekap RL, Chen R, Mistry Kannan T, Molski TF, Yocca FD, Sharp T, Kikuchi T, Burris KD.

Psychopharmacology (Berl). 2007 Feb;190(3):373-82. Epub 2006 Nov 25.

PMID:
17242925
[PubMed - indexed for MEDLINE]
5.

'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.

Zhang J, Zhang H, Cai W, Yu L, Zhen X, Zhang A.

Bioorg Med Chem. 2009 Jul 15;17(14):4873-80. doi: 10.1016/j.bmc.2009.06.019. Epub 2009 Jun 16.

PMID:
19559623
[PubMed - indexed for MEDLINE]
6.

SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug.

McCreary AC, Glennon JC, Ashby CR Jr, Meltzer HY, Li Z, Reinders JH, Hesselink MB, Long SK, Herremans AH, van Stuivenberg H, Feenstra RW, Kruse CG.

Neuropsychopharmacology. 2007 Jan;32(1):78-94. Epub 2006 May 17.

PMID:
16710314
[PubMed - indexed for MEDLINE]
Free Article
7.

The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D₂ and serotonin 5-HT₁A receptors.

Heusler P, Bruins Slot L, Tourette A, Tardif S, Cussac D.

Eur J Pharmacol. 2011 Nov 1;669(1-3):51-8. doi: 10.1016/j.ejphar.2011.07.031. Epub 2011 Aug 5.

PMID:
21835172
[PubMed - indexed for MEDLINE]
8.

Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.

Campiani G, Butini S, Fattorusso C, Catalanotti B, Gemma S, Nacci V, Morelli E, Cagnotto A, Mereghetti I, Mennini T, Carli M, Minetti P, Di Cesare MA, Mastroianni D, Scafetta N, Galletti B, Stasi MA, Castorina M, Pacifici L, Vertechy M, Di Serio S, Ghirardi O, Tinti O, Carminati P.

J Med Chem. 2004 Jan 1;47(1):143-57.

PMID:
14695828
[PubMed - indexed for MEDLINE]
9.

Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist.

Picard M, Morisset S, Cloix JF, Bizot JC, Guerin M, Beneteau V, Guillaumet G, Hevor TK.

Neuroscience. 2010 Sep 1;169(3):1337-46. doi: 10.1016/j.neuroscience.2010.05.040. Epub 2010 May 24.

PMID:
20580787
[PubMed - indexed for MEDLINE]
10.

F15063, a potential antipsychotic with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. I. In vitro receptor affinity and efficacy profile.

Newman-Tancredi A, Assié MB, Martel JC, Cosi C, Slot LB, Palmier C, Rauly-Lestienne I, Colpaert F, Vacher B, Cussac D.

Br J Pharmacol. 2007 May;151(2):237-52. Epub 2007 Mar 20.

PMID:
17375087
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.

Liu Z, Chen X, Sun P, Yu L, Zhen X, Zhang A.

Bioorg Med Chem. 2008 Sep 15;16(18):8335-8. doi: 10.1016/j.bmc.2008.08.056. Epub 2008 Aug 28.

PMID:
18783955
[PubMed - indexed for MEDLINE]
12.

New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.

Fiorino F, Perissutti E, Severino B, Santagada V, Cirillo D, Terracciano S, Massarelli P, Bruni G, Collavoli E, Renner C, Caliendo G.

J Med Chem. 2005 Aug 25;48(17):5495-503.

PMID:
16107148
[PubMed - indexed for MEDLINE]
13.

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity.

Brennan JA, Graf R, Grauer SM, Navarra RL, Pulicicchio CM, Hughes ZA, Lin Q, Wantuch C, Rosenzweig-Lipson S, Pruthi F, Lai M, Smith D, Goutier W, van de Neut M, Robichaud AJ, Rotella D, Feenstra RW, Kruse C, Broqua P, Beyer CE, McCreary AC, Pausch MH, Marquis KL.

J Pharmacol Exp Ther. 2010 Jan;332(1):190-201. doi: 10.1124/jpet.109.157388. Epub 2009 Oct 14.

PMID:
19828876
[PubMed - indexed for MEDLINE]
Free Article
14.

Homology modeling of the human 5-HT1A, 5-HT 2A, D1, and D2 receptors: model refinement with molecular dynamics simulations and docking evaluation.

Yap BK, Buckle MJ, Doughty SW.

J Mol Model. 2012 Aug;18(8):3639-55. doi: 10.1007/s00894-012-1368-5. Epub 2012 Feb 22.

PMID:
22354276
[PubMed - indexed for MEDLINE]
15.

In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain.

Bortolozzi A, Díaz-Mataix L, Toth M, Celada P, Artigas F.

Psychopharmacology (Berl). 2007 Apr;191(3):745-58. Epub 2007 Jan 30.

PMID:
17265076
[PubMed - indexed for MEDLINE]
16.

PD 158771, a potential antipsychotic agent with D(2)/D(3) partial agonist and 5-HT(1A) agonist actions. I. Neurochemical effects.

Akunne HC, Zoski KT, Davis MD, Cooke LW, Meltzer LT, Whetzel SZ, Shih YH, Wustrow DJ, Wise LD, MacKenzie RG, Georgic LM, Heffner TG, Pugsley TA.

Neuropharmacology. 2000 Apr 27;39(7):1197-210.

PMID:
10760362
[PubMed - indexed for MEDLINE]
17.

Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.

Carro L, Raviña E, Domínguez E, Brea J, Loza MI, Masaguer CF.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6059-62. doi: 10.1016/j.bmcl.2009.09.041. Epub 2009 Sep 17.

PMID:
19796944
[PubMed - indexed for MEDLINE]
18.

Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.

Zajdel P, Subra G, Bojarski AJ, Duszyńska B, Tatarczyńska E, Nikiforuk A, Chojnacka-Wójcik E, Pawłowski M, Martinez J.

Bioorg Med Chem. 2007 Apr 15;15(8):2907-19. Epub 2007 Feb 13.

PMID:
17321139
[PubMed - indexed for MEDLINE]
19.

5-HT(2A) and D(2) receptor blockade increases cortical DA release via 5-HT(1A) receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release.

Ichikawa J, Ishii H, Bonaccorso S, Fowler WL, O'Laughlin IA, Meltzer HY.

J Neurochem. 2001 Mar;76(5):1521-31.

PMID:
11238736
[PubMed - indexed for MEDLINE]
20.

l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity.

Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen XC.

Synapse. 2011 May;65(5):379-87. doi: 10.1002/syn.20855. Epub 2010 Sep 24.

PMID:
20803620
[PubMed - indexed for MEDLINE]

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