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Items: 1 to 20 of 86

1.

Role of the constitutive androstane receptor in obesity and type 2 diabetes: a case study of the endobiotic function of a xenobiotic receptor.

Jiang M, Xie W.

Drug Metab Rev. 2013 Feb;45(1):156-63. doi: 10.3109/03602532.2012.743561. Review.

PMID:
23330547
2.

The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity.

Gao J, He J, Zhai Y, Wada T, Xie W.

J Biol Chem. 2009 Sep 18;284(38):25984-92. doi: 10.1074/jbc.M109.016808. Epub 2009 Jul 17.

3.

Constitutive androstane receptor (CAR) is a xenosensor and target for therapy.

Kachaylo EM, Pustylnyak VO, Lyakhovich VV, Gulyaeva LF.

Biochemistry (Mosc). 2011 Oct;76(10):1087-97. doi: 10.1134/S0006297911100026. Review.

PMID:
22098234
4.

Targeting xenobiotic receptors PXR and CAR for metabolic diseases.

Gao J, Xie W.

Trends Pharmacol Sci. 2012 Oct;33(10):552-8. doi: 10.1016/j.tips.2012.07.003. Epub 2012 Aug 10. Review.

5.

A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses.

Zhai Y, Wada T, Zhang B, Khadem S, Ren S, Kuruba R, Li S, Xie W.

Mol Pharmacol. 2010 Oct;78(4):666-74. doi: 10.1124/mol.110.064618. Epub 2010 Jun 30.

6.

Functional crosstalk of CAR-LXR and ROR-LXR in drug metabolism and lipid metabolism.

Xiao L, Xie X, Zhai Y.

Adv Drug Deliv Rev. 2010 Oct 30;62(13):1316-21. doi: 10.1016/j.addr.2010.07.006. Epub 2010 Jul 24. Review.

PMID:
20659512
7.

Nuclear receptors in bile acid metabolism.

Li T, Chiang JY.

Drug Metab Rev. 2013 Feb;45(1):145-55. doi: 10.3109/03602532.2012.740048. Review.

8.

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond.

Chai X, Zeng S, Xie W.

Expert Opin Drug Metab Toxicol. 2013 Mar;9(3):253-66. doi: 10.1517/17425255.2013.754010. Epub 2013 Jan 17. Review.

PMID:
23327618
9.

Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.

Shizu R, Benoki S, Numakura Y, Kodama S, Miyata M, Yamazoe Y, Yoshinari K.

PLoS One. 2013 Apr 23;8(4):e61802. doi: 10.1371/journal.pone.0061802. Print 2013.

10.

CAR, the continuously advancing receptor, in drug metabolism and disease.

Qatanani M, Moore DD.

Curr Drug Metab. 2005 Aug;6(4):329-39. Review.

PMID:
16101572
11.

Deciphering the roles of the constitutive androstane receptor in energy metabolism.

Yan J, Chen B, Lu J, Xie W.

Acta Pharmacol Sin. 2015 Jan;36(1):62-70. doi: 10.1038/aps.2014.102. Epub 2014 Dec 15. Review.

12.

The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor.

Liu MJ, Takahashi Y, Wada T, He J, Gao J, Tian Y, Li S, Xie W.

Mol Pharmacol. 2009 Sep;76(3):604-11. doi: 10.1124/mol.109.057455. Epub 2009 Jun 19.

13.

Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.

Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18831-6. doi: 10.1073/pnas.0909731106. Epub 2009 Oct 22.

14.

PXR and CAR in energy metabolism.

Wada T, Gao J, Xie W.

Trends Endocrinol Metab. 2009 Aug;20(6):273-9. doi: 10.1016/j.tem.2009.03.003. Review.

PMID:
19595610
15.

The emerging role of constitutive androstane receptor and its cross talk with liver X receptors and peroxisome proliferator-activated receptor A in lipid metabolism.

Xiao L, Wang J, Jiang M, Xie W, Zhai Y.

Vitam Horm. 2013;91:243-58. doi: 10.1016/B978-0-12-407766-9.00010-9. Review.

PMID:
23374719
16.

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.

Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA.

Mol Pharmacol. 2002 Sep;62(3):638-46.

17.

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.

Zhang J, Huang W, Qatanani M, Evans RM, Moore DD.

J Biol Chem. 2004 Nov 19;279(47):49517-22. Epub 2004 Sep 8.

18.

Xenosensors CAR and PXR at work: impact on statin metabolism.

Marino M, di Masi A, Trezza V, Pallottini V, Polticelli F, Ascenzi P.

Curr Drug Metab. 2011 Mar;12(3):300-11. Review.

PMID:
21395534
19.

Small-molecule modulators of the constitutive androstane receptor.

Cherian MT, Chai SC, Chen T.

Expert Opin Drug Metab Toxicol. 2015 Jul;11(7):1099-114. doi: 10.1517/17425255.2015.1043887. Epub 2015 May 15. Review.

20.

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA.

J Biol Chem. 2000 May 19;275(20):15122-7.

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