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Results: 1 to 20 of 85

1.

Proteostasis modulators prolong missense VHL protein activity and halt tumor progression.

Yang C, Huntoon K, Ksendzovsky A, Zhuang Z, Lonser RR.

Cell Rep. 2013 Jan 31;3(1):52-9. doi: 10.1016/j.celrep.2012.12.007. Epub 2013 Jan 10.

PMID:
23318261
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease.

Zatyka M, da Silva NF, Clifford SC, Morris MR, Wiesener MS, Eckardt KU, Houlston RS, Richards FM, Latif F, Maher ER.

Cancer Res. 2002 Jul 1;62(13):3803-11.

PMID:
12097293
[PubMed - indexed for MEDLINE]
Free Article
3.

Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.

Miller F, Kentsis A, Osman R, Pan ZQ.

J Biol Chem. 2005 Mar 4;280(9):7985-96. Epub 2004 Dec 20.

PMID:
15611064
[PubMed - indexed for MEDLINE]
Free Article
4.

Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones.

Tsuchiya MI, Okuda H, Takaki Y, Baba M, Hirai S, Ohno S, Shuin T.

Oncol Rep. 2005 Jun;13(6):1033-41.

PMID:
15870918
[PubMed - indexed for MEDLINE]
5.

von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage.

Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD.

Oncogene. 2011 Jul 14;30(28):3127-38. doi: 10.1038/onc.2011.40. Epub 2011 Feb 28.

PMID:
21358672
[PubMed - indexed for MEDLINE]
6.
7.

VHL gene mutations and their effects on hypoxia inducible factor HIFα: identification of potential driver and passenger mutations.

Rechsteiner MP, von Teichman A, Nowicka A, Sulser T, Schraml P, Moch H.

Cancer Res. 2011 Aug 15;71(16):5500-11. doi: 10.1158/0008-5472.CAN-11-0757. Epub 2011 Jun 29.

PMID:
21715564
[PubMed - indexed for MEDLINE]
Free Article
8.

The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.

Zhou L, Yang H.

PLoS One. 2011;6(9):e23936. doi: 10.1371/journal.pone.0023936. Epub 2011 Sep 16.

PMID:
21949687
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.

Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM.

BMC Cancer. 2012 Jul 17;12:293. doi: 10.1186/1471-2407-12-293.

PMID:
22804960
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.

Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G.

J Biol Chem. 2002 Feb 15;277(7):4656-62. Epub 2001 Dec 5.

PMID:
11739384
[PubMed - indexed for MEDLINE]
Free Article
11.

A variety of phenotype with R161Q germline mutation of the von Hippel-Lindau tumor suppressor gene in Japanese kindred.

Iida K, Okimura Y, Takahashi K, Inomata S, Iguchi G, Kaji H, Chihara K.

Int J Mol Med. 2004 Mar;13(3):401-4.

PMID:
14767570
[PubMed - indexed for MEDLINE]
12.

The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.

Niu X, Zhang T, Liao L, Zhou L, Lindner DJ, Zhou M, Rini B, Yan Q, Yang H.

Oncogene. 2012 Feb 9;31(6):776-86. doi: 10.1038/onc.2011.266. Epub 2011 Jul 4.

PMID:
21725364
[PubMed - indexed for MEDLINE]
13.

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi AF, Mao M, Bartz S, Kaelin WG Jr.

Mol Cell Biol. 2007 Aug;27(15):5381-92. Epub 2007 May 25.

PMID:
17526729
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.

Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E.

Cancer Res. 2014 Jun 1;74(11):3127-36. doi: 10.1158/0008-5472.CAN-13-3213. Epub 2014 Apr 22.

PMID:
24755468
[PubMed - indexed for MEDLINE]
15.

Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.

Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, Escudier B, Azzarone B, Caignard A.

Oncogene. 2011 Jun 9;30(23):2622-32. doi: 10.1038/onc.2010.638. Epub 2011 Jan 24.

PMID:
21258414
[PubMed - indexed for MEDLINE]
16.

Overexpression of von Hippel-Lindau protein synergizes with doxorubicin to suppress hepatocellular carcinoma in mice.

Wang J, Ma Y, Jiang H, Zhu H, Liu L, Sun B, Pan S, Krissansen GW, Sun X.

J Hepatol. 2011 Aug;55(2):359-68. doi: 10.1016/j.jhep.2010.10.043. Epub 2010 Dec 17.

PMID:
21168458
[PubMed - indexed for MEDLINE]
17.

Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein.

Nakamura E, Abreu-e-Lima P, Awakura Y, Inoue T, Kamoto T, Ogawa O, Kotani H, Manabe T, Zhang GJ, Kondo K, Nosé V, Kaelin WG Jr.

Am J Pathol. 2006 Feb;168(2):574-84.

PMID:
16436671
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH.

J Biol Chem. 2000 Aug 18;275(33):25733-41.

PMID:
10823831
[PubMed - indexed for MEDLINE]
Free Article
19.

The von Hippel-Lindau tumor suppressor gene.

Kondo K, Kaelin WG Jr.

Exp Cell Res. 2001 Mar 10;264(1):117-25. Review.

PMID:
11237528
[PubMed - indexed for MEDLINE]
20.

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG Jr.

Hum Mol Genet. 2001 May 1;10(10):1019-27.

PMID:
11331612
[PubMed - indexed for MEDLINE]
Free Article

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