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Results: 1 to 20 of 63

1.

Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.

Wu J, Zhang D, Chen L, Li J, Wang J, Ning C, Yu N, Zhao F, Chen D, Chen X, Chen K, Jiang H, Liu H, Liu D.

J Med Chem. 2013 Feb 14;56(3):761-80. doi: 10.1021/jm301032j. Epub 2013 Jan 28.

PMID:
23316803
[PubMed - indexed for MEDLINE]
2.

A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide.

Feng Y, Wu J, Chen L, Luo C, Shen X, Chen K, Jiang H, Liu D.

Anal Biochem. 2009 Dec 15;395(2):205-10. doi: 10.1016/j.ab.2009.08.011. Epub 2009 Aug 13.

PMID:
19682970
[PubMed - indexed for MEDLINE]
3.

SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL.

J Biol Chem. 2010 Oct 22;285(43):32695-703. doi: 10.1074/jbc.M110.133892. Epub 2010 Aug 11.

PMID:
20702418
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682. Epub 2010 Jan 8.

PMID:
20061378
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.

Zhao X, Allison D, Condon B, Zhang F, Gheyi T, Zhang A, Ashok S, Russell M, MacEwan I, Qian Y, Jamison JA, Luz JG.

J Med Chem. 2013 Feb 14;56(3):963-9. doi: 10.1021/jm301431y. Epub 2013 Jan 29.

PMID:
23311358
[PubMed - indexed for MEDLINE]
6.

A molecular mechanism for direct sirtuin activation by resveratrol.

Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C.

PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21.

PMID:
23185430
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Resveratrol is not a direct activator of SIRT1 enzyme activity.

Beher D, Wu J, Cumine S, Kim KW, Lu SC, Atangan L, Wang M.

Chem Biol Drug Des. 2009 Dec;74(6):619-24. doi: 10.1111/j.1747-0285.2009.00901.x. Epub 2009 Oct 20.

PMID:
19843076
[PubMed - indexed for MEDLINE]
8.

Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1.

Chen L, Feng Y, Zhou Y, Zhu W, Shen X, Chen K, Jiang H, Liu D.

J Inorg Biochem. 2010 Feb;104(2):180-5. doi: 10.1016/j.jinorgbio.2009.10.021. Epub 2009 Oct 29.

PMID:
19923004
[PubMed - indexed for MEDLINE]
9.

Structural and functional analysis of human SIRT1.

Davenport AM, Huber FM, Hoelz A.

J Mol Biol. 2014 Feb 6;426(3):526-41. doi: 10.1016/j.jmb.2013.10.009. Epub 2013 Oct 10.

PMID:
24120939
[PubMed - indexed for MEDLINE]
Free Article
10.

Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA.

Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097.

PMID:
23471411
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.

Huhtiniemi T, Salo HS, Suuronen T, Poso A, Salminen A, Leppänen J, Jarho E, Lahtela-Kakkonen M.

J Med Chem. 2011 Oct 13;54(19):6456-68. doi: 10.1021/jm200590k. Epub 2011 Sep 7.

PMID:
21895016
[PubMed - indexed for MEDLINE]
12.

CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.

Kang H, Jung JW, Kim MK, Chung JH.

PLoS One. 2009 Aug 14;4(8):e6611. doi: 10.1371/journal.pone.0006611.

PMID:
19680552
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.

Zu Y, Liu L, Lee MY, Xu C, Liang Y, Man RY, Vanhoutte PM, Wang Y.

Circ Res. 2010 Apr 30;106(8):1384-93. doi: 10.1161/CIRCRESAHA.109.215483. Epub 2010 Mar 4.

PMID:
20203304
[PubMed - indexed for MEDLINE]
Free Article
14.

A patent review of sirtuin activators: an update.

Villalba JM, de Cabo R, Alcain FJ.

Expert Opin Ther Pat. 2012 Apr;22(4):355-67. doi: 10.1517/13543776.2012.669374. Epub 2012 Mar 9. Review.

PMID:
22475539
[PubMed - indexed for MEDLINE]
15.

Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.

Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K.

Mol Biosyst. 2011 Jan;7(1):59-66. doi: 10.1039/c0mb00026d. Epub 2010 Oct 8.

PMID:
20931131
[PubMed - indexed for MEDLINE]
16.

Sirtuin 1 (SIRT1): the misunderstood HDAC.

Stünkel W, Campbell RM.

J Biomol Screen. 2011 Dec;16(10):1153-69. doi: 10.1177/1087057111422103. Epub 2011 Nov 15. Review.

PMID:
22086720
[PubMed - indexed for MEDLINE]
17.

SIRT1 contains N- and C-terminal regions that potentiate deacetylase activity.

Pan M, Yuan H, Brent M, Ding EC, Marmorstein R.

J Biol Chem. 2012 Jan 20;287(4):2468-76. doi: 10.1074/jbc.M111.285031. Epub 2011 Dec 7.

PMID:
22157016
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators.

Vu CB, Bemis JE, Disch JS, Ng PY, Nunes JJ, Milne JC, Carney DP, Lynch AV, Smith JJ, Lavu S, Lambert PD, Gagne DJ, Jirousek MR, Schenk S, Olefsky JM, Perni RB.

J Med Chem. 2009 Mar 12;52(5):1275-83. doi: 10.1021/jm8012954.

PMID:
19199480
[PubMed - indexed for MEDLINE]
19.

Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers.

Nogalska A, D'Agostino C, Engel WK, Davies KJ, Askanas V.

Neurobiol Aging. 2010 Sep;31(9):1637-48. doi: 10.1016/j.neurobiolaging.2008.08.021. Epub 2008 Oct 14.

PMID:
18922603
[PubMed - indexed for MEDLINE]
20.

Comparative deacetylase activity of wild type and mutants of SIRT1.

Malik R, Kashyap A, Bansal K, Sharma P, Rayasam GV, Davis JA, Bora RS, Ray A, Saini KS.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):739-43. doi: 10.1016/j.bbrc.2009.11.130. Epub 2009 Nov 26.

PMID:
19944070
[PubMed - indexed for MEDLINE]

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