Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 130

1.

Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.

Narita K, Fukui Y, Sano Y, Yamori T, Ito A, Yoshida M, Katoh T.

Eur J Med Chem. 2013 Feb;60:295-304. doi: 10.1016/j.ejmech.2012.12.023. Epub 2012 Dec 21.

PMID:
23313638
[PubMed - indexed for MEDLINE]
2.

Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity.

Narita K, Kikuchi T, Watanabe K, Takizawa T, Oguchi T, Kudo K, Matsuhara K, Abe H, Yamori T, Yoshida M, Katoh T.

Chemistry. 2009 Oct 26;15(42):11174-86. doi: 10.1002/chem.200901552.

PMID:
19760730
[PubMed - indexed for MEDLINE]
3.

Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.

Fukui Y, Narita K, Dan S, Yamori T, Ito A, Yoshida M, Katoh T.

Eur J Med Chem. 2014 Apr 9;76:301-13. doi: 10.1016/j.ejmech.2014.02.044. Epub 2014 Feb 18.

PMID:
24589486
[PubMed - in process]
4.

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.

Yurek-George A, Cecil AR, Mo AH, Wen S, Rogers H, Habens F, Maeda S, Yoshida M, Packham G, Ganesan A.

J Med Chem. 2007 Nov 15;50(23):5720-6. Epub 2007 Oct 24.

PMID:
17958342
[PubMed - indexed for MEDLINE]
5.

Histone deacetylase inhibitors from microorganisms: the Astellas experience.

Masuoka Y, Shindoh N, Inamura N.

Prog Drug Res. 2008;66:335, 337-59. Review.

PMID:
18416310
[PubMed - indexed for MEDLINE]
6.

FK228 (depsipeptide): a HDAC inhibitor with pleiotropic antitumor activities.

Konstantinopoulos PA, Vandoros GP, Papavassiliou AG.

Cancer Chemother Pharmacol. 2006 Nov;58(5):711-5. Epub 2006 Jan 25. Review.

PMID:
16435156
[PubMed - indexed for MEDLINE]
7.

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.

Bowers A, West N, Taunton J, Schreiber SL, Bradner JE, Williams RM.

J Am Chem Soc. 2008 Aug 20;130(33):11219-22. doi: 10.1021/ja8033763. Epub 2008 Jul 19.

PMID:
18642817
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.

Wang C, Henkes LM, Doughty LB, He M, Wang D, Meyer-Almes FJ, Cheng YQ.

J Nat Prod. 2011 Oct 28;74(10):2031-8. doi: 10.1021/np200324x. Epub 2011 Jul 27.

PMID:
21793558
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Total synthesis and molecular target of largazole, a histone deacetylase inhibitor.

Ying Y, Taori K, Kim H, Hong J, Luesch H.

J Am Chem Soc. 2008 Jul 2;130(26):8455-9. doi: 10.1021/ja8013727. Epub 2008 May 29.

PMID:
18507379
[PubMed - indexed for MEDLINE]
10.

Synthesis and activity of largazole analogues with linker and macrocycle modification.

Ying Y, Liu Y, Byeon SR, Kim H, Luesch H, Hong J.

Org Lett. 2008 Sep 18;10(18):4021-4. doi: 10.1021/ol801532s. Epub 2008 Aug 16.

PMID:
18707106
[PubMed - indexed for MEDLINE]
11.

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

Benelkebir H, Marie S, Hayden AL, Lyle J, Loadman PM, Crabb SJ, Packham G, Ganesan A.

Bioorg Med Chem. 2011 Jun 15;19(12):3650-8. doi: 10.1016/j.bmc.2011.02.024. Epub 2011 Feb 17.

PMID:
21420302
[PubMed - indexed for MEDLINE]
12.

Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis.

Kwon HJ, Kim MS, Kim MJ, Nakajima H, Kim KW.

Int J Cancer. 2002 Jan 20;97(3):290-6.

PMID:
11774279
[PubMed - indexed for MEDLINE]
13.

Synthesis and biological evaluation of c7-demethyl largazole analogues.

Chen F, Gao AH, Li J, Nan FJ.

ChemMedChem. 2009 Aug;4(8):1269-72. doi: 10.1002/cmdc.200900125. No abstract available. Erratum in: ChemMedChem. 2009 Aug;4(8):1217.

PMID:
19431162
[PubMed - indexed for MEDLINE]
14.

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors.

Guan P, Sun F, Hou X, Wang F, Yi F, Xu W, Fang H.

Bioorg Med Chem. 2012 Jun 15;20(12):3865-72. doi: 10.1016/j.bmc.2012.04.032. Epub 2012 Apr 21.

PMID:
22579621
[PubMed - indexed for MEDLINE]
15.

Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.

Bhansali P, Hanigan CL, Casero RA, Tillekeratne LM.

J Med Chem. 2011 Nov 10;54(21):7453-63. doi: 10.1021/jm200432a. Epub 2011 Oct 10.

PMID:
21936551
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects.

Liao V, Liu T, Codd R.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6200-4. doi: 10.1016/j.bmcl.2012.08.006. Epub 2012 Aug 9.

PMID:
22932316
[PubMed - indexed for MEDLINE]
17.

Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.

Souto JA, Vaz E, Lepore I, Pöppler AC, Franci G, Alvarez R, Altucci L, de Lera AR.

J Med Chem. 2010 Jun 24;53(12):4654-67. doi: 10.1021/jm100244y.

PMID:
20491440
[PubMed - indexed for MEDLINE]
18.

Histone deacetylase inhibitors from Burkholderia thailandensis.

Klausmeyer P, Shipley SM, Zuck KM, McCloud TG.

J Nat Prod. 2011 Oct 28;74(10):2039-44. doi: 10.1021/np200532d. Epub 2011 Oct 3.

PMID:
21967146
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group.

Chen PC, Patil V, Guerrant W, Green P, Oyelere AK.

Bioorg Med Chem. 2008 May 1;16(9):4839-53. doi: 10.1016/j.bmc.2008.03.050. Epub 2008 Mar 23.

PMID:
18397827
[PubMed - indexed for MEDLINE]
20.

Efficient solid-phase synthesis of FK228 analogues as potent antitumoral agents.

Di Maro S, Pong RC, Hsieh JT, Ahn JM.

J Med Chem. 2008 Nov 13;51(21):6639-41. doi: 10.1021/jm800959f. Epub 2008 Oct 8.

PMID:
18839938
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk