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Conditional deletion of the Pten gene in the mouse prostate induces prostatic intraepithelial neoplasms at early ages but a slow progression to prostate tumors.

Kwak MK, Johnson DT, Zhu C, Lee SH, Ye DW, Luong R, Sun Z.

PLoS One. 2013;8(1):e53476. doi: 10.1371/journal.pone.0053476. Epub 2013 Jan 8.


Conditional expression of the androgen receptor induces oncogenic transformation of the mouse prostate.

Zhu C, Luong R, Zhuo M, Johnson DT, McKenney JK, Cunha GR, Sun Z.

J Biol Chem. 2011 Sep 23;286(38):33478-88. doi: 10.1074/jbc.M111.269894. Epub 2011 Jul 27.


Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis.

Ma X, Ziel-van der Made AC, Autar B, van der Korput HA, Vermeij M, van Duijn P, Cleutjens KB, de Krijger R, Krimpenfort P, Berns A, van der Kwast TH, Trapman J.

Cancer Res. 2005 Jul 1;65(13):5730-9.


The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision.

Luchman HA, Benediktsson H, Villemaire ML, Peterson AC, Jirik FR.

PLoS One. 2008;3(12):e3940. doi: 10.1371/journal.pone.0003940. Epub 2008 Dec 15.


Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma.

Ratnacaram CK, Teletin M, Jiang M, Meng X, Chambon P, Metzger D.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2521-6. doi: 10.1073/pnas.0712021105. Epub 2008 Feb 11.


An inducible knockout mouse to model the cell-autonomous role of PTEN in initiating endometrial, prostate and thyroid neoplasias.

Mirantes C, Eritja N, Dosil MA, Santacana M, Pallares J, Gatius S, Bergadà L, Maiques O, Matias-Guiu X, Dolcet X.

Dis Model Mech. 2013 May;6(3):710-20. doi: 10.1242/dmm.011445. Epub 2013 Feb 8.


Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma.

Adisetiyo H, Liang M, Liao CP, Aycock-Williams A, Cohen MB, Xu S, Neamati N, Conway EM, Cheng CY, Nikitin AY, Roy-Burman P.

PLoS One. 2013 Jul 31;8(7):e69484. doi: 10.1371/journal.pone.0069484. Print 2013.


Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model.

Korsten H, Ziel-van der Made A, Ma X, van der Kwast T, Trapman J.

PLoS One. 2009 May 22;4(5):e5662. doi: 10.1371/journal.pone.0005662.


Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium.

Huang J, Powell WC, Khodavirdi AC, Wu J, Makita T, Cardiff RD, Cohen MB, Sucov HM, Roy-Burman P.

Cancer Res. 2002 Aug 15;62(16):4812-9.


Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis.

Zhong C, Saribekyan G, Liao CP, Cohen MB, Roy-Burman P.

Cancer Res. 2006 Feb 15;66(4):2188-94.


Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways.

Xing C, Ci X, Sun X, Fu X, Zhang Z, Dong EN, Hao ZZ, Dong JT.

Neoplasia. 2014 Nov 20;16(11):883-99. doi: 10.1016/j.neo.2014.09.006. eCollection 2014 Nov.


Cooperation between Stat3 and Akt signaling leads to prostate tumor development in transgenic mice.

Blando JM, Carbajal S, Abel E, Beltran L, Conti C, Fischer S, DiGiovanni J.

Neoplasia. 2011 Mar;13(3):254-65.


Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia.

Abdulkadir SA, Magee JA, Peters TJ, Kaleem Z, Naughton CK, Humphrey PA, Milbrandt J.

Mol Cell Biol. 2002 Mar;22(5):1495-503.


Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia.

Narlik-Grassow M, Blanco-Aparicio C, Cecilia Y, Perez M, Muñoz-Galvan S, Cañamero M, Renner O, Carnero A.

PLoS One. 2013;8(4):e60277. doi: 10.1371/journal.pone.0060277. Epub 2013 Apr 2. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/1b8b6002-4e0f-4c5d-8ae8-fd45447b6149. Renner, Oliver [added].


Mutation of the androgen receptor causes oncogenic transformation of the prostate.

Ratliff TL.

J Urol. 2005 Sep;174(3):1149. No abstract available.


Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.

Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H.

Cancer Cell. 2003 Sep;4(3):209-21.


Activation of Akt signaling in prostate induces a TGFβ-mediated restraint on cancer progression and metastasis.

Bjerke GA, Yang CS, Frierson HF, Paschal BM, Wotton D.

Oncogene. 2014 Jul 10;33(28):3660-7. doi: 10.1038/onc.2013.342. Epub 2013 Sep 2.


Conditionally ablated Pten in prostate basal cells promotes basal-to-luminal differentiation and causes invasive prostate cancer in mice.

Lu TL, Huang YF, You LR, Chao NC, Su FY, Chang JL, Chen CM.

Am J Pathol. 2013 Mar;182(3):975-91. doi: 10.1016/j.ajpath.2012.11.025. Epub 2013 Jan 9.


Concomitant loss of EAF2/U19 and Pten synergistically promotes prostate carcinogenesis in the mouse model.

Ai J, Pascal LE, O'Malley KJ, Dar JA, Isharwal S, Qiao Z, Ren B, Rigatti LH, Dhir R, Xiao W, Nelson JB, Wang Z.

Oncogene. 2014 May 1;33(18):2286-94. doi: 10.1038/onc.2013.190. Epub 2013 May 27.


The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer.

Tien JC, Liu Z, Liao L, Wang F, Xu Y, Wu YL, Zhou N, Ittmann M, Xu J.

Cancer Res. 2013 Jul 1;73(13):3997-4008. doi: 10.1158/0008-5472.CAN-12-3929. Epub 2013 May 6.

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