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Results: 1 to 20 of 98

1.

[Progress of research and development of MAPK pathway inhibitors].

Ishii N.

Nihon Yakurigaku Zasshi. 2013 Jan;141(1):15-21. Review. Japanese. No abstract available.

PMID:
23302943
[PubMed - indexed for MEDLINE]
2.

Upstream mitogen-activated protein kinase (MAPK) pathway inhibition: MEK inhibitor followed by a BRAF inhibitor in advanced melanoma patients.

Goldinger SM, Zimmer L, Schulz C, Ugurel S, Hoeller C, Kaehler KC, Schadendorf D, Hassel JC, Becker J, Hauschild A, Dummer R; Dermatology Cooperative Oncology Group (DeCOG).

Eur J Cancer. 2014 Jan;50(2):406-10. doi: 10.1016/j.ejca.2013.09.014. Epub 2013 Oct 29.

PMID:
24183461
[PubMed - indexed for MEDLINE]
3.

Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.

Bahadoran P, Allegra M, Le Duff F, Long-Mira E, Hofman P, Giacchero D, Passeron T, Lacour JP, Ballotti R.

J Clin Oncol. 2013 Jul 1;31(19):e324-6. doi: 10.1200/JCO.2012.46.1061. Epub 2013 May 28. No abstract available.

PMID:
23715574
[PubMed - indexed for MEDLINE]
Free Article
4.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S.

Nature. 2010 Mar 18;464(7287):431-5. doi: 10.1038/nature08833. Epub 2010 Feb 3.

PMID:
20130576
[PubMed - indexed for MEDLINE]
5.

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

Roberts PJ, Der CJ.

Oncogene. 2007 May 14;26(22):3291-310. Review.

PMID:
17496923
[PubMed - indexed for MEDLINE]
6.

Functional profiling of live melanoma samples using a novel automated platform.

Schayowitz A, Bertenshaw G, Jeffries E, Schatz T, Cotton J, Villanueva J, Herlyn M, Krepler C, Vultur A, Xu W, Yu GH, Schuchter L, Clark DP.

PLoS One. 2012;7(12):e52760. doi: 10.1371/journal.pone.0052760. Epub 2012 Dec 28.

PMID:
23285177
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

Steelman LS, Franklin RA, Abrams SL, Chappell W, Kempf CR, Bäsecke J, Stivala F, Donia M, Fagone P, Nicoletti F, Libra M, Ruvolo P, Ruvolo V, Evangelisti C, Martelli AM, McCubrey JA.

Leukemia. 2011 Jul;25(7):1080-94. doi: 10.1038/leu.2011.66. Epub 2011 Apr 15. Review.

PMID:
21494257
[PubMed - indexed for MEDLINE]
9.

Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies.

Lee JT Jr, McCubrey JA.

Expert Opin Ther Targets. 2002 Dec;6(6):659-78. Review.

PMID:
12472379
[PubMed - indexed for MEDLINE]
10.

Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations.

Greger JG, Eastman SD, Zhang V, Bleam MR, Hughes AM, Smitheman KN, Dickerson SH, Laquerre SG, Liu L, Gilmer TM.

Mol Cancer Ther. 2012 Apr;11(4):909-20. doi: 10.1158/1535-7163.MCT-11-0989. Epub 2012 Mar 2.

PMID:
22389471
[PubMed - indexed for MEDLINE]
Free Article
11.

Advances in targeting the Ras/Raf/MEK/Erk mitogen-activated protein kinase cascade with MEK inhibitors for cancer therapy.

Friday BB, Adjei AA.

Clin Cancer Res. 2008 Jan 15;14(2):342-6. doi: 10.1158/1078-0432.CCR-07-4790.

PMID:
18223206
[PubMed - indexed for MEDLINE]
Free Article
12.

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.

Chakravarty D, Santos E, Ryder M, Knauf JA, Liao XH, West BL, Bollag G, Kolesnick R, Thin TH, Rosen N, Zanzonico P, Larson SM, Refetoff S, Ghossein R, Fagin JA.

J Clin Invest. 2011 Dec;121(12):4700-11. doi: 10.1172/JCI46382. Epub 2011 Nov 21.

PMID:
22105174
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Novel mitogen-activated protein kinase kinase inhibitors.

Chapman MS, Miner JN.

Expert Opin Investig Drugs. 2011 Feb;20(2):209-20. doi: 10.1517/13543784.2011.548803. Review.

PMID:
21235429
[PubMed - indexed for MEDLINE]
14.

Drug discovery: inhibitors that activate.

Cichowski K, Jänne PA.

Nature. 2010 Mar 18;464(7287):358-9. doi: 10.1038/464358a. No abstract available.

PMID:
20237552
[PubMed - indexed for MEDLINE]
15.

Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling.

Chen J, Shen Q, Labow M, Gaither LA.

Cancer Res. 2011 Jun 15;71(12):4280-91. doi: 10.1158/0008-5472.CAN-10-3761. Epub 2011 Apr 28.

PMID:
21527556
[PubMed - indexed for MEDLINE]
Free Article
16.

[Current status of combination therapies of angiogenesis inhibitors: vascular normalization activity of a novel angiogenesis inhibitor E7820].

Semba T.

Nihon Yakurigaku Zasshi. 2013 Jan;141(1):4-8. Review. Japanese. No abstract available.

PMID:
23302941
[PubMed - indexed for MEDLINE]
17.

GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition.

Gilmartin AG, Bleam MR, Groy A, Moss KG, Minthorn EA, Kulkarni SG, Rominger CM, Erskine S, Fisher KE, Yang J, Zappacosta F, Annan R, Sutton D, Laquerre SG.

Clin Cancer Res. 2011 Mar 1;17(5):989-1000. doi: 10.1158/1078-0432.CCR-10-2200. Epub 2011 Jan 18. Erratum in: Clin Cancer Res. 2012 Apr 15;18(8):2413.

PMID:
21245089
[PubMed - indexed for MEDLINE]
Free Article
18.

Cancer therapy based on oncogene addiction.

McCormick F.

J Surg Oncol. 2011 May 1;103(6):464-7. doi: 10.1002/jso.21749. Review.

PMID:
21480237
[PubMed - indexed for MEDLINE]
19.
20.

Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.

Sanada S, Kitakaze M, Papst PJ, Asanuma H, Node K, Takashima S, Asakura M, Ogita H, Liao Y, Sakata Y, Ogai A, Fukushima T, Yamada J, Shinozaki Y, Kuzuya T, Mori H, Terada N, Hori M.

Circulation. 2001 Aug 7;104(6):705-10.

PMID:
11489779
[PubMed - indexed for MEDLINE]
Free Article

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