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Results: 1 to 20 of 102

1.

How insulin engages its primary binding site on the insulin receptor.

Menting JG, Whittaker J, Margetts MB, Whittaker LJ, Kong GK, Smith BJ, Watson CJ, Záková L, Kletvíková E, Jiráček J, Chan SJ, Steiner DF, Dodson GG, Brzozowski AM, Weiss MA, Ward CW, Lawrence MC.

Nature. 2013 Jan 10;493(7431):241-5. doi: 10.1038/nature11781.

PMID:
23302862
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.

Smith BJ, Huang K, Kong G, Chan SJ, Nakagawa S, Menting JG, Hu SQ, Whittaker J, Steiner DF, Katsoyannis PG, Ward CW, Weiss MA, Lawrence MC.

Proc Natl Acad Sci U S A. 2010 Apr 13;107(15):6771-6. doi: 10.1073/pnas.1001813107. Epub 2010 Mar 26.

PMID:
20348418
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.

Menting JG, Ward CW, Margetts MB, Lawrence MC.

Biochemistry. 2009 Jun 16;48(23):5492-500. doi: 10.1021/bi900261q.

PMID:
19459609
[PubMed - indexed for MEDLINE]
4.

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase.

Whittaker J, Whittaker LJ, Roberts CT Jr, Phillips NB, Ismail-Beigi F, Lawrence MC, Weiss MA.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11166-71. doi: 10.1073/pnas.1205681109. Epub 2012 Jun 26.

PMID:
22736795
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

Huang K, Xu B, Hu SQ, Chu YC, Hua QX, Qu Y, Li B, Wang S, Wang RY, Nakagawa SH, Theede AM, Whittaker J, De Meyts P, Katsoyannis PG, Weiss MA.

J Mol Biol. 2004 Aug 6;341(2):529-50.

PMID:
15276842
[PubMed - indexed for MEDLINE]
6.

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

Wan ZL, Huang K, Xu B, Hu SQ, Wang S, Chu YC, Katsoyannis PG, Weiss MA.

Biochemistry. 2005 Apr 5;44(13):5000-16.

PMID:
15794638
[PubMed - indexed for MEDLINE]
7.

Characterization of a second ligand binding site of the insulin receptor.

Hao C, Whittaker L, Whittaker J.

Biochem Biophys Res Commun. 2006 Aug 18;347(1):334-9. Epub 2006 Jun 22.

PMID:
16814253
[PubMed - indexed for MEDLINE]
8.

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.

Lou M, Garrett TP, McKern NM, Hoyne PA, Epa VC, Bentley JD, Lovrecz GO, Cosgrove LJ, Frenkel MJ, Ward CW.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12429-34. Epub 2006 Aug 7.

PMID:
16894147
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

Xu B, Hu SQ, Chu YC, Huang K, Nakagawa SH, Whittaker J, Katsoyannis PG, Weiss MA.

Biochemistry. 2004 Jul 6;43(26):8356-72.

PMID:
15222748
[PubMed - indexed for MEDLINE]
10.

Quaternary structure of the insulin-insulin receptor complex.

Luo RZ, Beniac DR, Fernandes A, Yip CC, Ottensmeyer FP.

Science. 1999 Aug 13;285(5430):1077-80.

PMID:
10446056
[PubMed - indexed for MEDLINE]
Free Article
11.

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

Xu B, Huang K, Chu YC, Hu SQ, Nakagawa S, Wang S, Wang RY, Whittaker J, Katsoyannis PG, Weiss MA.

J Biol Chem. 2009 May 22;284(21):14597-608. doi: 10.1074/jbc.M900087200. Epub 2009 Mar 25.

PMID:
19321435
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice.

Huang K, Chan SJ, Hua QX, Chu YC, Wang RY, Klaproth B, Jia W, Whittaker J, De Meyts P, Nakagawa SH, Steiner DF, Katsoyannis PG, Weiss MA.

J Biol Chem. 2007 Nov 30;282(48):35337-49. Epub 2007 Sep 20.

PMID:
17884811
[PubMed - indexed for MEDLINE]
Free Article
13.

Receptor binding redefined by a structural switch in a mutant human insulin.

Hua QX, Shoelson SE, Kochoyan M, Weiss MA.

Nature. 1991 Nov 21;354(6350):238-41.

PMID:
1961250
[PubMed - indexed for MEDLINE]
14.

All-atom structural models of insulin binding to the insulin receptor in the presence of a tandem hormone-binding element.

Vashisth H, Abrams CF.

Proteins. 2013 Jun;81(6):1017-30. doi: 10.1002/prot.24255. Epub 2013 Feb 27.

PMID:
23348915
[PubMed - indexed for MEDLINE]
15.

The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules.

Ward CW, Garrett TP.

BMC Bioinformatics. 2001;2:4. Epub 2001 Jul 27.

PMID:
11504559
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.

Whittaker L, Hao C, Fu W, Whittaker J.

Biochemistry. 2008 Dec 2;47(48):12900-9. doi: 10.1021/bi801693h.

PMID:
18991400
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues.

Jirácek J, Záková L, Antolíková E, Watson CJ, Turkenburg JP, Dodson GG, Brzozowski AM.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):1966-70. doi: 10.1073/pnas.0911785107. Epub 2010 Jan 25.

PMID:
20133841
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Direct determination of the insulin-insulin receptor interface using transferred cross-saturation experiments.

Nakamura T, Takahashi H, Takahashi M, Shimba N, Suzuki E, Shimada I.

J Med Chem. 2010 Mar 11;53(5):1917-22. doi: 10.1021/jm901099v.

PMID:
20158183
[PubMed - indexed for MEDLINE]
19.

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change.

Whitten AE, Smith BJ, Menting JG, Margetts MB, McKern NM, Lovrecz GO, Adams TE, Richards K, Bentley JD, Trewhella J, Ward CW, Lawrence MC.

J Mol Biol. 2009 Dec 18;394(5):878-92. doi: 10.1016/j.jmb.2009.10.011. Epub 2009 Oct 14.

PMID:
19835884
[PubMed - indexed for MEDLINE]
20.

Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.

Wan Z, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA.

Biochemistry. 2004 Dec 28;43(51):16119-33.

PMID:
15610006
[PubMed - indexed for MEDLINE]

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