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Results: 1 to 20 of 102

1.

Phenyl linker-induced dense PEG conformation improves the efficacy of C-terminally monoPEGylated staphylokinase.

Xue X, Li D, Yu J, Ma G, Su Z, Hu T.

Biomacromolecules. 2013 Feb 11;14(2):331-41. doi: 10.1021/bm301511w. Epub 2013 Jan 18.

PMID:
23301655
[PubMed - indexed for MEDLINE]
2.

Molecular insight into the steric shielding effect of PEG on the conjugated staphylokinase: biochemical characterization and molecular dynamics simulation.

Mu Q, Hu T, Yu J.

PLoS One. 2013 Jul 18;8(7):e68559. doi: 10.1371/journal.pone.0068559. Print 2013.

PMID:
23874671
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Phenyl Amide Linker Improves the Pharmacokinetics and Pharmacodynamics of N-Terminally Mono-PEGylated Human Growth Hormone.

Wu L, Ji S, Shen L, Hu T.

Mol Pharm. 2014 Aug 21. [Epub ahead of print]

PMID:
25115329
[PubMed - as supplied by publisher]
4.

Kinetic and stoichiometric analysis of the modification process for N-terminal PEGylation of staphylokinase.

Wang J, Hu T, Liu Y, Zhang G, Ma G, Su Z.

Anal Biochem. 2011 May 1;412(1):114-6. doi: 10.1016/j.ab.2010.12.030. Epub 2010 Dec 24.

PMID:
21185800
[PubMed - indexed for MEDLINE]
5.

A solid-phase adsorption method for PEGylation of human serum albumin and staphylokinase: preparation, purification and biochemical characterization.

Suo X, Lu X, Hu T, Ma G, Su Z.

Biotechnol Lett. 2009 Aug;31(8):1191-6. doi: 10.1007/s10529-009-9986-4. Epub 2009 Apr 3.

PMID:
19343505
[PubMed - indexed for MEDLINE]
6.

Clinical development of PEGylated recombinant staphylokinase (PEG-Sak) for bolus thrombolytic treatment of patients with acute myocardial infarction.

Moreadith RW, Collen D.

Adv Drug Deliv Rev. 2003 Sep 26;55(10):1337-45. Review.

PMID:
14499711
[PubMed - indexed for MEDLINE]
7.

Effect of site-specific PEGylation on the fibrinolytic activity, immunogenicity, and pharmacokinetics of staphylokinase.

Liu J, Wang Z, He J, Wang G, Zhang R, Zhao B.

Acta Biochim Biophys Sin (Shanghai). 2014 Aug 6. pii: gmu068. [Epub ahead of print]

PMID:
25098624
[PubMed - as supplied by publisher]
8.

Polyethylene glycol-derivatized cysteine-substitution variants of recombinant staphylokinase for single-bolus treatment of acute myocardial infarction.

Collen D, Sinnaeve P, Demarsin E, Moreau H, De Maeyer M, Jespers L, Laroche Y, Van de Werf F.

Circulation. 2000 Oct 10;102(15):1766-72.

PMID:
11023930
[PubMed - indexed for MEDLINE]
Free Article
9.

N-terminal mono-PEGylation of growth hormone antagonist: correlation of PEG size and pharmacodynamic behavior.

Wu L, Ho SV, Wang W, Gao J, Zhang G, Su Z, Hu T.

Int J Pharm. 2013 Sep 10;453(2):533-40. doi: 10.1016/j.ijpharm.2013.06.022. Epub 2013 Jun 21.

PMID:
23796830
[PubMed - indexed for MEDLINE]
10.

Collaborative Angiographic Patency Trial Of Recombinant Staphylokinase (CAPTORS II).

Armstrong PW, Burton J, Pakola S, Molhoek PG, Betriu A, Tendera M, Bode C, Adgey AA, Bar F, Vahanian A, Van de Werf F; CAPTORS II Investigators.

Am Heart J. 2003 Sep;146(3):484-8.

PMID:
12947367
[PubMed - indexed for MEDLINE]
11.

Protein carboxyl amidation increases the potential extent of protein polyethylene glycol conjugation.

Li S, Yang Z, Sun X, Tan Y, Yagi S, Hoffman RM.

Anal Biochem. 2004 Jul 15;330(2):264-71.

PMID:
15203332
[PubMed - indexed for MEDLINE]
12.
13.

PEGylation of octreotide: II. Effect of N-terminal mono-PEGylation on biological activity and pharmacokinetics.

Na DH, Lee KC, DeLuca PP.

Pharm Res. 2005 May;22(5):743-9. Epub 2005 May 17.

PMID:
15906169
[PubMed - indexed for MEDLINE]
14.

Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.

Basu A, Yang K, Wang M, Liu S, Chintala R, Palm T, Zhao H, Peng P, Wu D, Zhang Z, Hua J, Hsieh MC, Zhou J, Petti G, Li X, Janjua A, Mendez M, Liu J, Longley C, Zhang Z, Mehlig M, Borowski V, Viswanathan M, Filpula D.

Bioconjug Chem. 2006 May-Jun;17(3):618-30.

PMID:
16704199
[PubMed - indexed for MEDLINE]
15.

Site-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation.

Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA.

Bioconjug Chem. 2012 Aug 15;23(8):1648-60. doi: 10.1021/bc3002248. Epub 2012 Jul 25.

PMID:
22770564
[PubMed - indexed for MEDLINE]
16.

In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.

Sun X, Yang Z, Li S, Tan Y, Zhang N, Wang X, Yagi S, Yoshioka T, Takimoto A, Mitsushima K, Suginaka A, Frenkel EP, Hoffman RM.

Cancer Res. 2003 Dec 1;63(23):8377-83.

PMID:
14678999
[PubMed - indexed for MEDLINE]
Free Article
17.

N-terminal specificity of PEGylation of human bone morphogenetic protein-2 at acidic pH.

Hu J, Sebald W.

Int J Pharm. 2011 Jul 15;413(1-2):140-6. doi: 10.1016/j.ijpharm.2011.04.043. Epub 2011 Apr 22.

PMID:
21539904
[PubMed - indexed for MEDLINE]
18.

Structural and biophysical characterization of the 40 kDa PEG-interferon-alpha2a and its individual positional isomers.

Dhalluin C, Ross A, Leuthold LA, Foser S, Gsell B, Müller F, Senn H.

Bioconjug Chem. 2005 May-Jun;16(3):504-17.

PMID:
15898716
[PubMed - indexed for MEDLINE]
19.

Structural and biologic characterization of pegylated recombinant IFN-alpha2b.

Grace M, Youngster S, Gitlin G, Sydor W, Xie L, Westreich L, Jacobs S, Brassard D, Bausch J, Bordens R.

J Interferon Cytokine Res. 2001 Dec;21(12):1103-15.

PMID:
11798469
[PubMed - indexed for MEDLINE]
20.

Pharmacokinetic and thrombolytic properties of cysteine-linked polyethylene glycol derivatives of staphylokinase.

Vanwetswinkel S, Plaisance S, Zhi-Yong Z, Vanlinthout I, Brepoels K, Lasters I, Collen D, Jespers L.

Blood. 2000 Feb 1;95(3):936-42.

PMID:
10648406
[PubMed - indexed for MEDLINE]
Free Article

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