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Results: 1 to 20 of 99

1.

Dynamic regulation of phenylalanine hydroxylase by simulated redox manipulation.

Fuchs JE, Huber RG, von Grafenstein S, Wallnoefer HG, Spitzer GM, Fuchs D, Liedl KR.

PLoS One. 2012;7(12):e53005. doi: 10.1371/journal.pone.0053005. Epub 2012 Dec 31.

PMID:
23300845
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Regulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometry.

Li J, Dangott LJ, Fitzpatrick PF.

Biochemistry. 2010 Apr 20;49(15):3327-35. doi: 10.1021/bi1001294.

PMID:
20307070
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structural and stability effects of phosphorylation: Localized structural changes in phenylalanine hydroxylase.

Miranda FF, Thórólfsson M, Teigen K, Sanchez-Ruiz JM, Martínez A.

Protein Sci. 2004 May;13(5):1219-26.

PMID:
15096628
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

An additional substrate binding site in a bacterial phenylalanine hydroxylase.

Ronau JA, Paul LN, Fuchs JE, Corn IR, Wagner KT, Liedl KR, Abu-Omar MM, Das C.

Eur Biophys J. 2013 Sep;42(9):691-708. doi: 10.1007/s00249-013-0919-8. Epub 2013 Jul 17.

PMID:
23860686
[PubMed - indexed for MEDLINE]
6.

Human phenylalanine hydroxylase is activated by H2O2: a novel mechanism for increasing the L-tyrosine supply for melanogenesis in melanocytes.

Schallreuter KU, Wazir U, Kothari S, Gibbons NC, Moore J, Wood JM.

Biochem Biophys Res Commun. 2004 Sep 10;322(1):88-92.

PMID:
15313177
[PubMed - indexed for MEDLINE]
7.

Essential role of the N-terminal autoregulatory sequence in the regulation of phenylalanine hydroxylase.

Jennings IG, Teh T, Kobe B.

FEBS Lett. 2001 Jan 19;488(3):196-200.

PMID:
11163771
[PubMed - indexed for MEDLINE]
Free Article
8.

Activation of phenylalanine hydroxylase: effect of substitutions at Arg68 and Cys237.

Thórólfsson M, Teigen K, Martínez A.

Biochemistry. 2003 Apr 1;42(12):3419-28.

PMID:
12653545
[PubMed - indexed for MEDLINE]
10.

Reversing the substrate specificities of phenylalanine and tyrosine hydroxylase: aspartate 425 of tyrosine hydroxylase is essential for L-DOPA formation.

Daubner SC, Melendez J, Fitzpatrick PF.

Biochemistry. 2000 Aug 15;39(32):9652-61.

PMID:
10933781
[PubMed - indexed for MEDLINE]
11.

A flexible loop in tyrosine hydroxylase controls coupling of amino acid hydroxylation to tetrahydropterin oxidation.

Daubner SC, McGinnis JT, Gardner M, Kroboth SL, Morris AR, Fitzpatrick PF.

J Mol Biol. 2006 Jun 2;359(2):299-307. Epub 2006 Mar 24.

PMID:
16618490
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Characterization of chimeric pterin-dependent hydroxylases: contributions of the regulatory domains of tyrosine and phenylalanine hydroxylase to substrate specificity.

Daubner SC, Hillas PJ, Fitzpatrick PF.

Biochemistry. 1997 Sep 30;36(39):11574-82.

PMID:
9305947
[PubMed - indexed for MEDLINE]
13.

Phosphorylation and mutations of Ser(16) in human phenylalanine hydroxylase. Kinetic and structural effects.

Miranda FF, Teigen K, Thórólfsson M, Svebak RM, Knappskog PM, Flatmark T, Martínez A.

J Biol Chem. 2002 Oct 25;277(43):40937-43. Epub 2002 Aug 15.

PMID:
12185072
[PubMed - indexed for MEDLINE]
Free Article
14.
15.

Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis.

Zhang W, Ames BD, Walsh CT.

Biochemistry. 2011 Jun 21;50(24):5401-3. doi: 10.1021/bi200733c. Epub 2011 May 31.

PMID:
21615132
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Probing cofactor specificity in phenylalanine hydroxylase by molecular dynamics simulations.

Teigen K, Martinez A.

J Biomol Struct Dyn. 2003 Jun;20(6):733-40.

PMID:
12744702
[PubMed - indexed for MEDLINE]
17.
18.

Mechanism of "uncoupled" tetrahydropterin oxidation by phenylalanine hydroxylase.

Dix TA, Benkovic SJ.

Biochemistry. 1985 Oct 8;24(21):5839-46.

PMID:
4084494
[PubMed - indexed for MEDLINE]
20.

Role of the second coordination sphere residue tyrosine 179 in substrate affinity and catalytic activity of phenylalanine hydroxylase.

Zoidakis J, Sam M, Volner A, Han A, Vu K, Abu-Omar MM.

J Biol Inorg Chem. 2004 Apr;9(3):289-96. Epub 2004 Mar 4.

PMID:
14999516
[PubMed - indexed for MEDLINE]

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