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Results: 1 to 20 of 122

1.

Αlpha-synuclein levels in blood plasma from LRRK2 mutation carriers.

Gorostidi A, Bergareche A, Ruiz-Martínez J, Martí-Massó JF, Cruz M, Varghese S, Qureshi MM, Alzahmi F, Al-Hayani A, López de Munáin A, El-Agnaf OM.

PLoS One. 2012;7(12):e52312. doi: 10.1371/journal.pone.0052312. Epub 2012 Dec 27.

PMID:
23300640
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases.

Mamais A, Raja M, Manzoni C, Dihanich S, Lees A, Moore D, Lewis PA, Bandopadhyay R.

Neurobiol Dis. 2013 Oct;58:183-90. doi: 10.1016/j.nbd.2013.05.017. Epub 2013 Jun 5.

PMID:
23747310
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease.

El-Agnaf OM, Salem SA, Paleologou KE, Curran MD, Gibson MJ, Court JA, Schlossmacher MG, Allsop D.

FASEB J. 2006 Mar;20(3):419-25.

PMID:
16507759
[PubMed - indexed for MEDLINE]
Free Article
4.

LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease.

Alegre-Abarrategui J, Ansorge O, Esiri M, Wade-Martins R.

Neuropathol Appl Neurobiol. 2008 Jun;34(3):272-83. Epub 2007 Oct 26.

PMID:
17971075
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Involvement of the cerebral cortex in Parkinson disease linked with G2019S LRRK2 mutation without cognitive impairment.

Gomez A, Ferrer I.

Acta Neuropathol. 2010 Aug;120(2):155-67. doi: 10.1007/s00401-010-0669-y. Epub 2010 Mar 16.

PMID:
20232069
[PubMed - indexed for MEDLINE]
6.

α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls.

Smith LM, Schiess MC, Coffey MP, Klaver AC, Loeffler DA.

PLoS One. 2012;7(12):e52285. doi: 10.1371/journal.pone.0052285. Epub 2012 Dec 17.

PMID:
23284971
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models.

Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM.

J Mol Med (Berl). 2013 Apr;91(4):513-22. doi: 10.1007/s00109-012-0984-y. Epub 2012 Nov 27.

PMID:
23183827
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Reduced content of α-synuclein in peripheral blood leukocytes of patients with LRRK2-associated Parkinson's disease.

Pchelina SN, Emelyanov AK, Yakimovskii AF, Miller DW, Shabalina IG, Drozdova AS, Schwarzman AL.

Bull Exp Biol Med. 2011 Apr;150(6):679-81.

PMID:
22235415
[PubMed - indexed for MEDLINE]
9.

Variant in the 3' region of SNCA associated with Parkinson's disease and serum α-synuclein levels.

Hu Y, Tang B, Guo J, Wu X, Sun Q, Shi C, Hu L, Wang C, Wang L, Tan L, Shen L, Yan X, Zhang H.

J Neurol. 2012 Mar;259(3):497-504. doi: 10.1007/s00415-011-6209-4. Epub 2011 Aug 19.

PMID:
21853288
[PubMed - indexed for MEDLINE]
10.

Genetic factors influencing age at onset in LRRK2-linked Parkinson disease.

Golub Y, Berg D, Calne DB, Pfeiffer RF, Uitti RJ, Stoessl AJ, Wszolek ZK, Farrer MJ, Mueller JC, Gasser T, Fuchs J.

Parkinsonism Relat Disord. 2009 Aug;15(7):539-41. doi: 10.1016/j.parkreldis.2008.10.008. Epub 2008 Nov 28.

PMID:
19041274
[PubMed - indexed for MEDLINE]
11.

Age at onset in LRRK2-associated PD is modified by SNCA variants.

Botta-Orfila T, Ezquerra M, Pastor P, Fernández-Santiago R, Pont-Sunyer C, Compta Y, Lorenzo-Betancor O, Samaranch L, Martí MJ, Valldeoriola F, Calopa M, Fernández M, Aguilar M, de Fabregas O, Hernández-Vara J, Tolosa E.

J Mol Neurosci. 2012 Sep;48(1):245-7. doi: 10.1007/s12031-012-9820-7. Epub 2012 Jun 6.

PMID:
22669510
[PubMed - indexed for MEDLINE]
12.

Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.

Li QX, Mok SS, Laughton KM, McLean CA, Cappai R, Masters CL, Culvenor JG, Horne MK.

Exp Neurol. 2007 Apr;204(2):583-8. Epub 2006 Dec 19.

PMID:
17258710
[PubMed - indexed for MEDLINE]
13.

The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.

Lee PH, Lee G, Park HJ, Bang OY, Joo IS, Huh K.

J Neural Transm. 2006 Oct;113(10):1435-9. Epub 2006 Feb 9.

PMID:
16465458
[PubMed - indexed for MEDLINE]
14.

α-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients.

Yanamandra K, Gruden MA, Casaite V, Meskys R, Forsgren L, Morozova-Roche LA.

PLoS One. 2011 Apr 25;6(4):e18513. doi: 10.1371/journal.pone.0018513.

PMID:
21541339
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease.

Foulds PG, Mitchell JD, Parker A, Turner R, Green G, Diggle P, Hasegawa M, Taylor M, Mann D, Allsop D.

FASEB J. 2011 Dec;25(12):4127-37. doi: 10.1096/fj.10-179192. Epub 2011 Aug 24.

PMID:
21865317
[PubMed - indexed for MEDLINE]
Free Article
16.

Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinson's disease.

Yonova-Doing E, Atadzhanov M, Quadri M, Kelly P, Shawa N, Musonda ST, Simons EJ, Breedveld GJ, Oostra BA, Bonifati V.

Parkinsonism Relat Disord. 2012 Jun;18(5):567-71. doi: 10.1016/j.parkreldis.2012.02.018. Epub 2012 Mar 24.

PMID:
22445250
[PubMed - indexed for MEDLINE]
17.

G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies.

Gaig C, Martí MJ, Ezquerra M, Rey MJ, Cardozo A, Tolosa E.

J Neurol Neurosurg Psychiatry. 2007 Jun;78(6):626-8. Epub 2007 Jan 8.

PMID:
17210620
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease.

Nishioka K, Kefi M, Jasinska-Myga B, Wider C, Vilariño-Güell C, Ross OA, Heckman MG, Middleton LT, Ishihara-Paul L, Gibson RA, Amouri R, Ben Yahmed S, Ben Sassi S, Zouari M, El Euch G, Farrer MJ, Hentati F.

J Neurol Neurosurg Psychiatry. 2010 Apr;81(4):391-5. doi: 10.1136/jnnp.2009.185231. Epub 2009 Sep 2.

PMID:
19726410
[PubMed - indexed for MEDLINE]
19.

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ.

Hum Mol Genet. 2012 Jun 1;21(11):2420-31. doi: 10.1093/hmg/dds057. Epub 2012 Feb 21.

PMID:
22357653
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

α-Synuclein, leucine-rich repeat kinase-2, and manganese in the pathogenesis of Parkinson disease.

Covy JP, Giasson BI.

Neurotoxicology. 2011 Oct;32(5):622-9. doi: 10.1016/j.neuro.2011.01.003. Epub 2011 Jan 14. Review.

PMID:
21238487
[PubMed - indexed for MEDLINE]
Free PMC Article

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