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MMP13 is a critical target gene during the progression of osteoarthritis.

Wang M, Sampson ER, Jin H, Li J, Ke QH, Im HJ, Chen D.

Arthritis Res Ther. 2013 Jan 8;15(1):R5. doi: 10.1186/ar4133.


Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism.

Li J, Gorski DJ, Anemaet W, Velasco J, Takeuchi J, Sandy JD, Plaas A.

Arthritis Res Ther. 2012 Jun 21;14(3):R151. doi: 10.1186/ar3887.


Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model.

Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB.

Arthritis Res Ther. 2014 Dec 17;16(6):508. doi: 10.1186/s13075-014-0508-y.


Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.

Niebler S, Schubert T, Hunziker EB, Bosserhoff AK.

Arthritis Res Ther. 2015 May 12;17:119. doi: 10.1186/s13075-015-0648-8.


Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ.

Sci Transl Med. 2011 Sep 21;3(101):101ra93. doi: 10.1126/scitranslmed.3002214.


Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis.

Lorenz J, Seebach E, Hackmayer G, Greth C, Bauer RJ, Kleinschmidt K, Bettenworth D, Böhm M, Grifka J, Grässel S.

PLoS One. 2014 Sep 5;9(9):e105858. doi: 10.1371/journal.pone.0105858. eCollection 2014.


Knee loading reduces MMP13 activity in the mouse cartilage.

Hamamura K, Zhang P, Zhao L, Shim JW, Chen A, Dodge TR, Wan Q, Shih H, Na S, Lin CC, Sun HB, Yokota H.

BMC Musculoskelet Disord. 2013 Nov 1;14:312. doi: 10.1186/1471-2474-14-312.


Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.

Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D.

Arthritis Rheum. 2013 Dec;65(12):3107-19. doi: 10.1002/art.38122.


Effective knock down of matrix metalloproteinase-13 by an intra-articular injection of small interfering RNA (siRNA) in a murine surgically-induced osteoarthritis model.

Akagi R, Sasho T, Saito M, Endo J, Yamaguchi S, Muramatsu Y, Mukoyama S, Akatsu Y, Katsuragi J, Fukawa T, Takahashi K.

J Orthop Res. 2014 Sep;32(9):1175-80. doi: 10.1002/jor.22654. Epub 2014 May 22.


Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis.

Shimizu S, Asou Y, Itoh S, Chung UI, Kawaguchi H, Shinomiya K, Muneta T.

Arthritis Rheum. 2007 Oct;56(10):3358-65.


Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis.

Takayama K, Kawakami Y, Kobayashi M, Greco N, Cummins JH, Matsushita T, Kuroda R, Kurosaka M, Fu FH, Huard J.

Arthritis Res Ther. 2014 Nov 17;16(6):482. doi: 10.1186/s13075-014-0482-4.


Effect of Ermiao Recipe with medicinal guide Angelicae Pubescentis Radix on promoting the homing of bone marrow stem cells to treat cartilage damage in osteoarthritis rats.

Xu Y, Dai GJ, Liu Q, Ma XP, Li L, Chen WH, Lin N.

Chin J Integr Med. 2014 Aug;20(8):600-9. doi: 10.1007/s11655-014-1761-2. Epub 2014 Aug 5.


The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes--implications for osteoarthritis.

Imagawa K, de Andrés MC, Hashimoto K, Pitt D, Itoi E, Goldring MB, Roach HI, Oreffo RO.

Biochem Biophys Res Commun. 2011 Feb 18;405(3):362-7. doi: 10.1016/j.bbrc.2011.01.007. Epub 2011 Jan 8.


Chondrocyte death during murine osteoarthritis.

Mistry D, Oue Y, Chambers MG, Kayser MV, Mason RM.

Osteoarthritis Cartilage. 2004 Feb;12(2):131-41.


Global analyses of gene expression in early experimental osteoarthritis.

Appleton CT, Pitelka V, Henry J, Beier F.

Arthritis Rheum. 2007 Jun;56(6):1854-68.


Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.

Weng T, Yi L, Huang J, Luo F, Wen X, Du X, Chen Q, Deng C, Chen D, Chen L.

Arthritis Rheum. 2012 Dec;64(12):3982-92. doi: 10.1002/art.34645.


Osteoarthritis-like changes in the heterozygous sedc mouse associated with the HtrA1-Ddr2-Mmp-13 degradative pathway: a new model of osteoarthritis.

Holt DW, Henderson ML, Stockdale CE, Farrell JT, Kooyman DL, Bridgewater LC, Seegmiller RE.

Osteoarthritis Cartilage. 2012 May;20(5):430-9. doi: 10.1016/j.joca.2011.11.008. Epub 2011 Nov 26.


A 3D cartilage - inflammatory cell culture system for the modeling of human osteoarthritis.

Sun L, Wang X, Kaplan DL.

Biomaterials. 2011 Aug;32(24):5581-9. doi: 10.1016/j.biomaterials.2011.04.028. Epub 2011 May 12.

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