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Items: 1 to 20 of 120

1.

Hit identification of IKKβ natural product inhibitor.

Leung CH, Chan DS, Li YW, Fong WF, Ma DL.

BMC Pharmacol Toxicol. 2013 Jan 7;14:3. doi: 10.1186/2050-6511-14-3.

2.

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.

Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D.

BMC Genomics. 2010 Dec 2;11 Suppl 4:S25. doi: 10.1186/1471-2164-11-S4-S25.

3.

Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.

PMID:
17047224
4.

Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences.

Patil KR, Mohapatra P, Patel HM, Goyal SN, Ojha S, Kundu CN, Patil CR.

PLoS One. 2015 May 4;10(5):e0125709. doi: 10.1371/journal.pone.0125709. eCollection 2015.

5.

IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.

Adli M, Merkhofer E, Cogswell P, Baldwin AS.

PLoS One. 2010 Feb 25;5(2):e9428. doi: 10.1371/journal.pone.0009428.

6.

Magnolol suppresses NF-kappaB activation and NF-kappaB regulated gene expression through inhibition of IkappaB kinase activation.

Tse AK, Wan CK, Zhu GY, Shen XL, Cheung HY, Yang M, Fong WF.

Mol Immunol. 2007 Apr;44(10):2647-58. Epub 2007 Jan 22.

PMID:
17240450
7.

Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation.

Tse AK, Wan CK, Shen XL, Yang M, Fong WF.

Biochem Pharmacol. 2005 Nov 15;70(10):1443-57. Epub 2005 Sep 21.

PMID:
16181613
9.

A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells.

Wen D, Nong Y, Morgan JG, Gangurde P, Bielecki A, Dasilva J, Keaveney M, Cheng H, Fraser C, Schopf L, Hepperle M, Harriman G, Jaffee BD, Ocain TD, Xu Y.

J Pharmacol Exp Ther. 2006 Jun;317(3):989-1001. Epub 2006 Mar 8.

12.

IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

Li X, Massa PE, Hanidu A, Peet GW, Aro P, Savitt A, Mische S, Li J, Marcu KB.

J Biol Chem. 2002 Nov 22;277(47):45129-40. Epub 2002 Sep 6.

13.

H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells.

Maeda S, Yoshida H, Ogura K, Mitsuno Y, Hirata Y, Yamaji Y, Akanuma M, Shiratori Y, Omata M.

Gastroenterology. 2000 Jul;119(1):97-108.

PMID:
10889159
14.

IKKβ inhibitor identification: a multi-filter driven novel scaffold.

Nagarajan S, Choo H, Cho YS, Shin KJ, Oh KS, Lee BH, Pae AN.

BMC Bioinformatics. 2010 Oct 15;11 Suppl 7:S15. doi: 10.1186/1471-2105-11-S7-S15.

16.

Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases.

Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET Jr, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC.

Mol Cell Biol. 1998 Sep;18(9):5157-65.

17.

IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.

Yamamoto Y, Yin MJ, Gaynor RB.

Mol Cell Biol. 2000 May;20(10):3655-66.

18.

A homogeneous time-resolved fluorescence-based high-throughput screening system for discovery of inhibitors of IKKbeta-NEMO interaction.

Gotoh Y, Nagata H, Kase H, Shimonishi M, Ido M.

Anal Biochem. 2010 Oct 1;405(1):19-27. doi: 10.1016/j.ab.2010.05.028. Epub 2010 Jun 1.

PMID:
20522330
19.
20.

Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy.

Song H, Lee YS, Roh EJ, Seo JH, Oh KS, Lee BH, Han H, Shin KJ.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5668-74. doi: 10.1016/j.bmcl.2012.06.088. Epub 2012 Jul 15.

PMID:
22858099
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