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Radiation-related quality of life parameters after targeted intraoperative radiotherapy versus whole breast radiotherapy in patients with breast cancer: results from the randomized phase III trial TARGIT-A.

Welzel G, Boch A, Sperk E, Hofmann F, Kraus-Tiefenbacher U, Gerhardt A, Suetterlin M, Wenz F.

Radiat Oncol. 2013 Jan 7;8:9. doi: 10.1186/1748-717X-8-9.


Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A randomised trial.

Vaidya JS, Wenz F, Bulsara M, Tobias JS, Joseph DJ, Keshtgar M, Flyger HL, Massarut S, Alvarado M, Saunders C, Eiermann W, Metaxas M, Sperk E, Sütterlin M, Brown D, Esserman L, Roncadin M, Thompson A, Dewar JA, Holtveg HM, Pigorsch S, Falzon M, Harris E, Matthews A, Brew-Graves C, Potyka I, Corica T, Williams NR, Baum M; TARGIT trialists' group.

Lancet. 2014 Feb 15;383(9917):603-13. doi: 10.1016/S0140-6736(13)61950-9. Epub 2013 Nov 11. Erratum in: Lancet. 2014 Feb 15;383(9917):602.


Late radiation toxicity after intraoperative radiotherapy (IORT) for breast cancer: results from the randomized phase III trial TARGIT A.

Sperk E, Welzel G, Keller A, Kraus-Tiefenbacher U, Gerhardt A, Sütterlin M, Wenz F.

Breast Cancer Res Treat. 2012 Aug;135(1):253-60. doi: 10.1007/s10549-012-2168-4. Epub 2012 Jul 29.


Comparison of mammographic findings after intraoperative radiotherapy or external beam whole breast radiotherapy.

Elsberger B, Romsauerova A, Vinnicombe S, Whelehan P, Brown DC, Dewar JA, Thompson AM, Evans A.

Eur J Surg Oncol. 2014 Feb;40(2):163-7. doi: 10.1016/j.ejso.2013.11.011. Epub 2013 Dec 4.


A cohort analysis to identify eligible patients for intraoperative radiotherapy (IORT) of early breast cancer.

Sperk E, Astor D, Keller A, Welzel G, Gerhardt A, Tuschy B, Sütterlin M, Wenz F.

Radiat Oncol. 2014 Jul 12;9:154. doi: 10.1186/1748-717X-9-154.


Intraoperative radiotherapy (IORT) for breast cancer using the Intrabeam system.

Kraus-Tiefenbacher U, Scheda A, Steil V, Hermann B, Kehrer T, Bauer L, Melchert F, Wenz F.

Tumori. 2005 Jul-Aug;91(4):339-45.


Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial.

Corica T, Nowak AK, Saunders CM, Bulsara M, Taylor M, Vaidya JS, Baum M, Joseph DJ.

Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):55-64. doi: 10.1016/j.ijrobp.2016.04.024. Epub 2016 Apr 23.


Persistent pain after targeted intraoperative radiotherapy (TARGIT) or external breast radiotherapy for breast cancer: a randomized trial.

Andersen KG, Gärtner R, Kroman N, Flyger H, Kehlet H.

Breast. 2012 Feb;21(1):46-9. doi: 10.1016/j.breast.2011.07.011. Epub 2011 Aug 23.


Intraoperative radiotherapy for early breast cancer: do health professionals choose convenience or risk?

Corica T, Joseph D, Saunders C, Bulsara M, Nowak AK.

Radiat Oncol. 2014 Jan 25;9:33. doi: 10.1186/1748-717X-9-33.


Long-term results of targeted intraoperative radiotherapy (Targit) boost during breast-conserving surgery.

Vaidya JS, Baum M, Tobias JS, Wenz F, Massarut S, Keshtgar M, Hilaris B, Saunders C, Williams NR, Brew-Graves C, Corica T, Roncadin M, Kraus-Tiefenbacher U, Sütterlin M, Bulsara M, Joseph D.

Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):1091-7. doi: 10.1016/j.ijrobp.2010.07.1996. Epub 2010 Oct 15.


Application of a decision analytic framework for adoption of clinical trial results: are the data regarding TARGIT-A IORT ready for prime time?

Esserman LJ, Alvarado MD, Howe RJ, Mohan AJ, Harrison B, Park C, O'Donoghue C, Ozanne EM.

Breast Cancer Res Treat. 2014 Apr;144(2):371-8. doi: 10.1007/s10549-014-2881-2. Epub 2014 Mar 2.


Is IORT ready for roll-out?

Esposito E, Anninga B, Honey I, Ross G, Rainsbury D, Laws S, Rinsma S, Douek M.

Ecancermedicalscience. 2015 Mar 12;9:516. doi: 10.3332/ecancer.2015.516. eCollection 2015. Review.


Intraoperative radiotherapy as a boost during breast-conserving surgery using low-kilovoltage X-rays: the first 5 years of experience with a novel approach.

Wenz F, Welzel G, Blank E, Hermann B, Steil V, Sütterlin M, Kraus-Tiefenbacher U.

Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1309-14. doi: 10.1016/j.ijrobp.2009.06.085. Epub 2010 Jan 25.


Breast-conserving surgery with intra-operative radiotherapy: the right approach for the 21st century?

Tobias JS, Vaidya JS, Keshtgar M, Douek M, Metaxas M, Stacey C, Sainsbury R, D'Souza D, Baum M.

Clin Oncol (R Coll Radiol). 2006 Apr;18(3):220-8. Review.


Can the risk of secondary cancer induction after breast conserving therapy be reduced using intraoperative radiotherapy (IORT) with low-energy x-rays?

Aziz MH, Schneider F, Clausen S, Blank E, Herskind C, Afzal M, Wenz F.

Radiat Oncol. 2011 Dec 16;6:174. doi: 10.1186/1748-717X-6-174.


Intraoperative radiotherapy in early breast cancer.

Esposito E, Anninga B, Harris S, Capasso I, D'Aiuto M, Rinaldo M, Douek M.

Br J Surg. 2015 May;102(6):599-610. doi: 10.1002/bjs.9781. Epub 2015 Mar 17. Review.


Early initiation of external beam radiotherapy (EBRT) may increase the risk of long-term toxicity in patients undergoing intraoperative radiotherapy (IORT) as a boost for breast cancer.

Wenz F, Welzel G, Keller A, Blank E, Vorodi F, Herskind C, Tomé O, Sütterlin M, Kraus-Tiefenbacher U.

Breast. 2008 Dec;17(6):617-22. doi: 10.1016/j.breast.2008.05.009. Epub 2008 Jul 22.


Targeted intraoperative radiotherapy (TARGIT) yields very low recurrence rates when given as a boost.

Vaidya JS, Baum M, Tobias JS, Massarut S, Wenz F, Murphy O, Hilaris B, Houghton J, Saunders C, Corica T, Roncadin M, Kraus-Tiefenbacher U, Melchaert F, Keshtgar M, Sainsbury R, Douek M, Harrison E, Thompson A, Joseph D.

Int J Radiat Oncol Biol Phys. 2006 Dec 1;66(5):1335-8. Epub 2006 Nov 2.

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