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Aberrant activation of Hedgehog/Gli1 pathway on angiogenesis in gliomas.

Cui D, Chen X, Yin J, Wang W, Lou M, Gu S.

Neurol India. 2012 Nov-Dec;60(6):589-96. doi: 10.4103/0028-3886.105192.


Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines.

Wang K, Pan L, Che X, Cui D, Li C.

J Neurooncol. 2010 Jul;98(3):319-27. doi: 10.1007/s11060-009-0082-3. Epub 2009 Dec 19.


Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.


Inhibition of Nodal suppresses angiogenesis and growth of human gliomas.

Hueng DY, Lin GJ, Huang SH, Liu LW, Ju DT, Chen YW, Sytwu HK, Chang C, Huang SM, Yeh YS, Lee HM, Ma HI.

J Neurooncol. 2011 Aug;104(1):21-31. doi: 10.1007/s11060-010-0467-3. Epub 2010 Nov 30.


Sonic Hedgehog/GLI₁ signaling pathway inhibition restricts cell migration and invasion in human gliomas.

Wang K, Pan L, Che X, Cui D, Li C.

Neurol Res. 2010 Nov;32(9):975-80. doi: 10.1179/016164110X12681290831360. Epub 2010 May 4.


HMGA1 expression in human gliomas and its correlation with tumor proliferation, invasion and angiogenesis.

Pang B, Fan H, Zhang IY, Liu B, Feng B, Meng L, Zhang R, Sadeghi S, Guo H, Pang Q.

J Neurooncol. 2012 Feb;106(3):543-9. doi: 10.1007/s11060-011-0710-6. Epub 2011 Oct 8.


LKB1 inhibits breast cancer partially through repressing the Hedgehog signaling pathway.

Zhuang Z, Wang K, Cheng X, Qu X, Jiang B, Li Z, Luo J, Shao Z, Duan T.

PLoS One. 2013 Jul 4;8(7):e67431. doi: 10.1371/journal.pone.0067431. Print 2013.


Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.

Chen W, Tang T, Eastham-Anderson J, Dunlap D, Alicke B, Nannini M, Gould S, Yauch R, Modrusan Z, DuPree KJ, Darbonne WC, Plowman G, de Sauvage FJ, Callahan CA.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9589-94. doi: 10.1073/pnas.1017945108. Epub 2011 May 19.


Gli1 is a potential target for alleviating multidrug resistance of gliomas.

Cui D, Xu Q, Wang K, Che X.

J Neurol Sci. 2010 Jan 15;288(1-2):156-66. doi: 10.1016/j.jns.2009.09.006. Epub 2009 Oct 12.


Hedgehog signaling pathway is inactive in colorectal cancer cell lines.

Chatel G, Ganeff C, Boussif N, Delacroix L, Briquet A, Nolens G, Winkler R.

Int J Cancer. 2007 Dec 15;121(12):2622-7.


CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells.

Zhang S, Yang YL, Wang Y, You B, Dai Y, Chan G, Hsieh D, Kim IJ, Fang LT, Au A, Stoppler HJ, Xu Z, Jablons DM, You L.

J Exp Clin Cancer Res. 2014 Nov 25;33:93. doi: 10.1186/s13046-014-0093-6.


Hedgehog signaling pathway mediates invasion and metastasis of hepatocellular carcinoma via ERK pathway.

Lu JT, Zhao WD, He W, Wei W.

Acta Pharmacol Sin. 2012 May;33(5):691-700. doi: 10.1038/aps.2012.24. Epub 2012 Apr 30.


Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.

McCann CK, Growdon WB, Kulkarni-Datar K, Curley MD, Friel AM, Proctor JL, Sheikh H, Deyneko I, Ferguson JA, Vathipadiekal V, Birrer MJ, Borger DR, Mohapatra G, Zukerberg LR, Foster R, Macdougall JR, Rueda BR.

PLoS One. 2011;6(11):e28077. doi: 10.1371/journal.pone.0028077. Epub 2011 Nov 29.


Hedgehog signaling in small-cell lung cancer: frequent in vivo but a rare event in vitro.

Vestergaard J, Pedersen MW, Pedersen N, Ensinger C, Tümer Z, Tommerup N, Poulsen HS, Larsen LA.

Lung Cancer. 2006 Jun;52(3):281-90. Epub 2006 Apr 17.


The prognostic significance and therapeutic potential of hedgehog signaling in intrahepatic cholangiocellular carcinoma.

Tang L, Tan YX, Jiang BG, Pan YF, Li SX, Yang GZ, Wang M, Wang Q, Zhang J, Zhou WP, Dong LW, Wang HY.

Clin Cancer Res. 2013 Apr 15;19(8):2014-24. doi: 10.1158/1078-0432.CCR-12-0349. Epub 2013 Mar 14.


RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling.

Shimokawa T, Rahman MF, Tostar U, Sonkoly E, Ståhle M, Pivarcsi A, Palaniswamy R, Zaphiropoulos PG.

RNA Biol. 2013 Feb;10(2):321-33. doi: 10.4161/rna.23343. Epub 2013 Jan 16.


Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.

Duan F, Lin M, Li C, Ding X, Qian G, Zhang H, Ge S, Fan X, Li J.

Cancer Biol Ther. 2014 May;15(5):544-59. doi: 10.4161/cbt.28157. Epub 2014 Mar 11.


The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma.

Xu Q, Liu X, Zheng X, Yao Y, Wang M, Liu Q.

Int J Mol Med. 2014 Sep;34(3):733-41. doi: 10.3892/ijmm.2014.1847. Epub 2014 Jul 10.


Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation.

Nagai S, Nakamura M, Yanai K, Wada J, Akiyoshi T, Nakashima H, Ohuchida K, Sato N, Tanaka M, Katano M.

Cancer Sci. 2008 Jul;99(7):1377-84. doi: 10.1111/j.1349-7006.2008.00822.x. Epub 2008 Apr 11.


Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation.

Liao X, Siu MK, Au CW, Wong ES, Chan HY, Ip PP, Ngan HY, Cheung AN.

Carcinogenesis. 2009 Jan;30(1):131-40. doi: 10.1093/carcin/bgn230. Epub 2008 Nov 20.

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