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Results: 1 to 20 of 94

1.

Mammalian target of rapamycin inhibitor abrogates abnormal osteoclastogenesis in neurofibromatosis type 1.

Liu N, Xu N, Wei LH, Chai GL.

Chin Med J (Engl). 2013 Jan;126(1):101-7.

PMID:
23286486
[PubMed - indexed for MEDLINE]
Free Article
2.

Hyperactivation of mTOR critically regulates abnormal osteoclastogenesis in neurofibromatosis Type 1.

Ma J, Li M, Hock J, Yu X.

J Orthop Res. 2012 Jan;30(1):144-52. doi: 10.1002/jor.21497. Epub 2011 Jul 11.

PMID:
21748792
[PubMed - indexed for MEDLINE]
3.

Neurofibromatosis Type 1 and tumorigenesis: molecular mechanisms and therapeutic implications.

Gottfried ON, Viskochil DH, Couldwell WT.

Neurosurg Focus. 2010 Jan;28(1):E8. doi: 10.3171/2009.11.FOCUS09221.

PMID:
20043723
[PubMed - indexed for MEDLINE]
4.

A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells.

El-Hoss J, Sullivan K, Cheng T, Yu NY, Bobyn JD, Peacock L, Mikulec K, Baldock P, Alexander IE, Schindeler A, Little DG.

J Bone Miner Res. 2012 Jan;27(1):68-78. doi: 10.1002/jbmr.528.

PMID:
21956219
[PubMed - indexed for MEDLINE]
5.

Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors.

Dasgupta B, Yi Y, Chen DY, Weber JD, Gutmann DH.

Cancer Res. 2005 Apr 1;65(7):2755-60.

PMID:
15805275
[PubMed - indexed for MEDLINE]
Free Article
6.

Hyperactive Ras/MAPK signaling is critical for tibial nonunion fracture in neurofibromin-deficient mice.

Sharma R, Wu X, Rhodes SD, Chen S, He Y, Yuan J, Li J, Yang X, Li X, Jiang L, Kim ET, Stevenson DA, Viskochil D, Xu M, Yang FC.

Hum Mol Genet. 2013 Dec 1;22(23):4818-28. doi: 10.1093/hmg/ddt333. Epub 2013 Jul 17.

PMID:
23863460
[PubMed - indexed for MEDLINE]
7.

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1.

Yan J, Chen S, Zhang Y, Li X, Li Y, Wu X, Yuan J, Robling AG, Kapur R, Chan RJ, Yang FC.

Hum Mol Genet. 2008 Apr 1;17(7):936-48. Epub 2007 Dec 18. Erratum in: Hum Mol Genet. 2008 Jun 15;17(12):1876. Karpur, Reuben [corrected to Kapur, Reuben].

PMID:
18089636
[PubMed - indexed for MEDLINE]
Free Article
8.

Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft.

Bhola P, Banerjee S, Mukherjee J, Balasubramanium A, Arun V, Karim Z, Burrell K, Croul S, Gutmann DH, Guha A.

Int J Cancer. 2010 Jan 15;126(2):563-71. doi: 10.1002/ijc.24783.

PMID:
19634141
[PubMed - indexed for MEDLINE]
9.

c-Fms signaling mediates neurofibromatosis Type-1 osteoclast gain-in-functions.

He Y, Rhodes SD, Chen S, Wu X, Yuan J, Yang X, Jiang L, Li X, Takahashi N, Xu M, Mohammad KS, Guise TA, Yang FC.

PLoS One. 2012;7(11):e46900. doi: 10.1371/journal.pone.0046900. Epub 2012 Nov 7.

PMID:
23144792
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions.

Yang FC, Chen S, Robling AG, Yu X, Nebesio TD, Yan J, Morgan T, Li X, Yuan J, Hock J, Ingram DA, Clapp DW.

J Clin Invest. 2006 Nov;116(11):2880-91. Epub 2006 Oct 19.

PMID:
17053831
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Role of IGF-I signaling in regulating osteoclastogenesis.

Wang Y, Nishida S, Elalieh HZ, Long RK, Halloran BP, Bikle DD.

J Bone Miner Res. 2006 Sep;21(9):1350-8.

PMID:
16939393
[PubMed - indexed for MEDLINE]
12.

M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.

Glantschnig H, Fisher JE, Wesolowski G, Rodan GA, Reszka AA.

Cell Death Differ. 2003 Oct;10(10):1165-77.

PMID:
14502240
[PubMed - indexed for MEDLINE]
Free Article
13.

Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study.

Weiss B, Widemann BC, Wolters P, Dombi E, Vinks AA, Cantor A, Korf B, Perentesis J, Gutmann DH, Schorry E, Packer R, Fisher MJ.

Pediatr Blood Cancer. 2014 Jun;61(6):982-6.

PMID:
24851266
[PubMed - indexed for MEDLINE]
14.

Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis.

Cejka D, Hayer S, Niederreiter B, Sieghart W, Fuereder T, Zwerina J, Schett G.

Arthritis Rheum. 2010 Aug;62(8):2294-302. doi: 10.1002/art.27504.

PMID:
20506288
[PubMed - indexed for MEDLINE]
Free Article
15.

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

Johannessen CM, Reczek EE, James MF, Brems H, Legius E, Cichowski K.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8573-8. Epub 2005 Jun 3. Erratum in: Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16119.

PMID:
15937108
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Erythropoietin mediated bone formation is regulated by mTOR signaling.

Kim J, Jung Y, Sun H, Joseph J, Mishra A, Shiozawa Y, Wang J, Krebsbach PH, Taichman RS.

J Cell Biochem. 2012 Jan;113(1):220-8. doi: 10.1002/jcb.23347.

PMID:
21898543
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

P38 mitogen-activated protein kinase inhibitor, FR167653, inhibits parathyroid hormone related protein-induced osteoclastogenesis and bone resorption.

Tao H, Okamoto M, Nishikawa M, Yoshikawa H, Myoui A.

PLoS One. 2011;6(8):e23199. doi: 10.1371/journal.pone.0023199. Epub 2011 Aug 23.

PMID:
21886782
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Quercetin triggers apoptosis of lipopolysaccharide (LPS)-induced osteoclasts and inhibits bone resorption in RAW264.7 cells.

Guo C, Hou GQ, Li XD, Xia X, Liu DX, Huang DY, Du SX.

Cell Physiol Biochem. 2012;30(1):123-36. doi: 10.1159/000339052. Epub 2012 Jan 8.

PMID:
22759961
[PubMed - indexed for MEDLINE]
19.

Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes.

Sandsmark DK, Zhang H, Hegedus B, Pelletier CL, Weber JD, Gutmann DH.

Cancer Res. 2007 May 15;67(10):4790-9.

PMID:
17510408
[PubMed - indexed for MEDLINE]
Free Article
20.

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure.

Lin CY, Hsu SC, Lee HS, Lin SH, Tsai CS, Huang SM, Shih CC, Hsu YJ.

J Vasc Surg. 2013 Feb;57(2):475-85. doi: 10.1016/j.jvs.2012.07.037. Epub 2012 Dec 21.

PMID:
23265586
[PubMed - indexed for MEDLINE]

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