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1.

Flagellin induces myeloid-derived suppressor cells: implications for Pseudomonas aeruginosa infection in cystic fibrosis lung disease.

Rieber N, Brand A, Hector A, Graepler-Mainka U, Ost M, Schäfer I, Wecker I, Neri D, Wirth A, Mays L, Zundel S, Fuchs J, Handgretinger R, Stern M, Hogardt M, Döring G, Riethmüller J, Kormann M, Hartl D.

J Immunol. 2013 Feb 1;190(3):1276-84. doi: 10.4049/jimmunol.1202144. Epub 2012 Dec 31.

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Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia.

Morris AE, Liggitt HD, Hawn TR, Skerrett SJ.

Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1112-9. doi: 10.1152/ajplung.00155.2009. Epub 2009 Oct 2.

4.

Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease.

Blohmke CJ, Victor RE, Hirschfeld AF, Elias IM, Hancock DG, Lane CR, Davidson AG, Wilcox PG, Smith KD, Overhage J, Hancock RE, Turvey SE.

J Immunol. 2008 Jun 1;180(11):7764-73.

5.

Evaluation of flagella and flagellin of Pseudomonas aeruginosa as vaccines.

Campodónico VL, Llosa NJ, Grout M, Döring G, Maira-Litrán T, Pier GB.

Infect Immun. 2010 Feb;78(2):746-55. doi: 10.1128/IAI.00806-09. Epub 2009 Dec 7.

6.

Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5.

Zhang Z, Louboutin JP, Weiner DJ, Goldberg JB, Wilson JM.

Infect Immun. 2005 Nov;73(11):7151-60.

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8.

Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection.

Feldman M, Bryan R, Rajan S, Scheffler L, Brunnert S, Tang H, Prince A.

Infect Immun. 1998 Jan;66(1):43-51.

10.

Pseudomonas aeruginosa exploits lipid A and muropeptides modification as a strategy to lower innate immunity during cystic fibrosis lung infection.

Cigana C, Curcurù L, Leone MR, Ieranò T, Lorè NI, Bianconi I, Silipo A, Cozzolino F, Lanzetta R, Molinaro A, Bernardini ML, Bragonzi A.

PLoS One. 2009 Dec 23;4(12):e8439. doi: 10.1371/journal.pone.0008439.

11.

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.

Feuillet V, Medjane S, Mondor I, Demaria O, Pagni PP, Galán JE, Flavell RA, Alexopoulou L.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12487-92. Epub 2006 Aug 4.

12.

Infections with Pseudomonas aeruginosa in patients with cystic fibrosis.

Tümmler B, Bosshammer J, Breitenstein S, Brockhausen I, Gudowius P, Herrmann C, Herrmann S, Heuer T, Kubesch P, Mekus F, Römling U, Schmidt KD, Spangenberg C, Walter S.

Behring Inst Mitt. 1997 Feb;(98):249-55. Review.

PMID:
9382747
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14.

Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice.

Campodónico VL, Llosa NJ, Bentancor LV, Maira-Litran T, Pier GB.

Infect Immun. 2011 Aug;79(8):3455-64. doi: 10.1128/IAI.00157-11. Epub 2011 May 31.

15.

A crucial role of Flagellin in the induction of airway mucus production by Pseudomonas aeruginosa.

Ben Mohamed F, Garcia-Verdugo I, Medina M, Balloy V, Chignard M, Ramphal R, Touqui L.

PLoS One. 2012;7(7):e39888. doi: 10.1371/journal.pone.0039888. Epub 2012 Jul 2. Erratum in: PLoS One. 2012;7(8): doi/10.1371/annotation/7718a413-90cf-4183-9eb0-3a1b7c5bcd83. Mohamed, Fatima Ben [corrected to Ben Mohamed, Fatima]..

16.

Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa.

Skerrett SJ, Wilson CB, Liggitt HD, Hajjar AM.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L312-22. Epub 2006 Aug 25.

18.

TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease.

Koller B, Kappler M, Latzin P, Gaggar A, Schreiner M, Takyar S, Kormann M, Kabesch M, Roos D, Griese M, Hartl D.

J Immunol. 2008 Aug 15;181(4):2753-63.

19.

Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.

Blohmke CJ, Mayer ML, Tang AC, Hirschfeld AF, Fjell CD, Sze MA, Falsafi R, Wang S, Hsu K, Chilvers MA, Hogg JC, Hancock RE, Turvey SE.

J Immunol. 2012 Dec 1;189(11):5467-75. doi: 10.4049/jimmunol.1103661. Epub 2012 Oct 26.

20.

Hypersusceptibility of cystic fibrosis mice to chronic Pseudomonas aeruginosa oropharyngeal colonization and lung infection.

Coleman FT, Mueschenborn S, Meluleni G, Ray C, Carey VJ, Vargas SO, Cannon CL, Ausubel FM, Pier GB.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1949-54. Epub 2003 Feb 10.

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