Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 130

1.

An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells.

Cai M, Stankova M, Muthu D, Mayorov A, Yang Z, Trivedi D, Cabello C, Hruby VJ.

Biochemistry. 2013 Jan 29;52(4):752-64. doi: 10.1021/bi300723f. Epub 2013 Jan 15.

PMID:
23276279
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues.

Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ.

J Med Chem. 2003 Nov 6;46(23):4965-73.

PMID:
14584947
[PubMed - indexed for MEDLINE]
3.

De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.

Han G, Haskell-Luevano C, Kendall L, Bonner G, Hadley ME, Cone RD, Hruby VJ.

J Med Chem. 2004 Mar 11;47(6):1514-26.

PMID:
14998337
[PubMed - indexed for MEDLINE]
4.

Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.

Haskell-Luevano C, Nikiforovich G, Sharma SD, Yang YK, Dickinson C, Hruby VJ, Gantz I.

J Med Chem. 1997 May 23;40(11):1738-48.

PMID:
9171884
[PubMed - indexed for MEDLINE]
5.

Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands.

Wilczynski A, Wang XS, Joseph CG, Xiang Z, Bauzo RM, Scott JW, Sorensen NB, Shaw AM, Millard WJ, Richards NG, Haskell-Luevano C.

J Med Chem. 2004 Apr 22;47(9):2194-207.

PMID:
15084118
[PubMed - indexed for MEDLINE]
6.

Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist.

Han G, Quillan JM, Carlson K, Sadée W, Hruby VJ.

J Med Chem. 2003 Feb 27;46(5):810-9.

PMID:
12593660
[PubMed - indexed for MEDLINE]
7.
8.

Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[beta-Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 peptide template.

Wilczynski A, Wilson KR, Scott JW, Edison AS, Haskell-Luevano C.

J Med Chem. 2005 Apr 21;48(8):3060-75.

PMID:
15828845
[PubMed - indexed for MEDLINE]
9.

Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues.

Cai M, Mayorov AV, Cabello C, Stankova M, Trivedi D, Hruby VJ.

J Med Chem. 2005 Mar 24;48(6):1839-48.

PMID:
15771429
[PubMed - indexed for MEDLINE]
10.

Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R.

Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ.

J Med Chem. 2003 Aug 14;46(17):3728-33.

PMID:
12904077
[PubMed - indexed for MEDLINE]
11.

Chimeric NDP-MSH and MTII melanocortin peptides with agouti-related protein (AGRP) Arg-Phe-Phe amino acids possess agonist melanocortin receptor activity.

Joseph CG, Wilczynski A, Holder JR, Xiang Z, Bauzo RM, Scott JW, Haskell-Luevano C.

Peptides. 2003 Dec;24(12):1899-908.

PMID:
15127941
[PubMed - indexed for MEDLINE]
12.

Relevance of the C-terminal Arg-Phe sequence in gamma(2)-melanocyte-stimulating hormone (gamma(2)-MSH) for inducing cardiovascular effects in conscious rats.

Nijsen MJ, de Ruiter GJ, Kasbergen CM, Hoogerhout P, de Wildt DJ.

Br J Pharmacol. 2000 Dec;131(7):1468-74.

PMID:
11090122
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R.

Joseph CG, Yao H, Scott JW, Sorensen NB, Marnane RN, Mountjoy KG, Haskell-Luevano C.

Peptides. 2010 Dec;31(12):2304-13. doi: 10.1016/j.peptides.2010.08.025. Epub 2010 Sep 15.

PMID:
20833220
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Novel agouti-related-protein-based melanocortin-1 receptor antagonist.

Thirumoorthy R, Holder JR, Bauzo RM, Richards NG, Edison AS, Haskell-Luevano C.

J Med Chem. 2001 Nov 22;44(24):4114-24.

PMID:
11708914
[PubMed - indexed for MEDLINE]
15.

Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R.

Haskell-Luevano C, Miwa H, Dickinson C, Hadley ME, Hruby VJ, Yamada T, Gantz I.

J Med Chem. 1996 Jan 19;39(2):432-5.

PMID:
8558511
[PubMed - indexed for MEDLINE]
16.

Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position.

Grieco P, Cai M, Mayorov AV, Trivedi D, Hruby VJ.

Peptides. 2006 Feb;27(2):472-81. Epub 2005 Nov 21.

PMID:
16303211
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptors.

Mioni C, Giuliani D, Cainazzo MM, Leone S, Bazzani C, Grieco P, Novellino E, Tomasi A, Bertolini A, Guarini S.

Eur J Pharmacol. 2003 Sep 23;477(3):227-34. Erratum in: Eur J Pharmacol. 2004 Feb 20;486(2):237. Iannone C [corrected to Iannone A].

PMID:
14522361
[PubMed - indexed for MEDLINE]
18.

Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.

Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ.

J Med Chem. 2008 Jan 24;51(2):187-95. Epub 2007 Dec 19.

PMID:
18088090
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.

Grieco P, Balse PM, Weinberg D, MacNeil T, Hruby VJ.

J Med Chem. 2000 Dec 28;43(26):4998-5002.

PMID:
11150170
[PubMed - indexed for MEDLINE]
20.

Melanoma targeting with alpha-melanocyte stimulating hormone analogs labeled with fac-[99mTc(CO)3]+: effect of cyclization on tumor-seeking properties.

Raposinho PD, Xavier C, Correia JD, Falcão S, Gomes P, Santos I.

J Biol Inorg Chem. 2008 Mar;13(3):449-59. doi: 10.1007/s00775-007-0338-3. Epub 2008 Jan 8.

PMID:
18183429
[PubMed - indexed for MEDLINE]
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk