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Items: 1 to 20 of 85

1.

Molecular docking studies on inhibition of Stat3 dimerization by curcumin natural derivatives and its conjugates with amino acids.

Kumar A, Bora U.

Bioinformation. 2012;8(20):988-93. doi: 10.6026/97320630008988. Epub 2012 Oct 13.

2.

Investigation of the binding determinants of phosphopeptides targeted to the SRC homology 2 domain of the signal transducer and activator of transcription 3. Development of a high-affinity peptide inhibitor.

Coleman DR 4th, Ren Z, Mandal PK, Cameron AG, Dyer GA, Muranjan S, Campbell M, Chen X, McMurray JS.

J Med Chem. 2005 Oct 20;48(21):6661-70.

PMID:
16220982
3.

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.

Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lü J, Hoyt D, Lin J.

Mol Cancer. 2010 Aug 16;9:217. doi: 10.1186/1476-4598-9-217.

4.
5.

Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation.

Park IH, Li C.

J Mol Recognit. 2011 Mar-Apr;24(2):254-65. doi: 10.1002/jmr.1047.

PMID:
21360612
6.

Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.

Turkson J, Kim JS, Zhang S, Yuan J, Huang M, Glenn M, Haura E, Sebti S, Hamilton AD, Jove R.

Mol Cancer Ther. 2004 Mar;3(3):261-9.

7.

Two small molecule compounds, LLL12 and FLLL32, exhibit potent inhibitory activity on STAT3 in human rhabdomyosarcoma cells.

Wei CC, Ball S, Lin L, Liu A, Fuchs JR, Li PK, Li C, Lin J.

Int J Oncol. 2011 Jan;38(1):279-85.

PMID:
21109950
8.

A novel non-phosphorylated potential antitumoral peptide inhibits STAT3 biological activity.

Dourlat J, Liu WQ, Sancier F, Edmonds T, Pamonsinlapatham P, Cruzalegui F, Garbay C.

Biochimie. 2009 Aug;91(8):996-1002. doi: 10.1016/j.biochi.2009.05.006. Epub 2009 May 24.

PMID:
19470402
9.
10.

In Silico Inhibition Studies of Jun-Fos-DNA Complex Formation by Curcumin Derivatives.

Kumar A, Bora U.

Int J Med Chem. 2012;2012:316972. doi: 10.1155/2012/316972. Epub 2012 Dec 6.

11.

Binding modes of peptidomimetics designed to inhibit STAT3.

Dhanik A, McMurray JS, Kavraki LE.

PLoS One. 2012;7(12):e51603. doi: 10.1371/journal.pone.0051603. Epub 2012 Dec 12.

12.

Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.

Schust J, Sperl B, Hollis A, Mayer TU, Berg T.

Chem Biol. 2006 Nov;13(11):1235-42.

13.

Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.

Turkson J, Ryan D, Kim JS, Zhang Y, Chen Z, Haura E, Laudano A, Sebti S, Hamilton AD, Jove R.

J Biol Chem. 2001 Nov 30;276(48):45443-55. Epub 2001 Sep 28.

14.
15.

Primary and tertiary structure of the principal human adenylate kinase.

Von Zabern I, Wittmann-Liebold B, Untucht-Grau R, Schirmer RH, Pai EF.

Eur J Biochem. 1976 Sep;68(1):281-90.

16.

Novel high-throughput screening system for identifying STAT3-SH2 antagonists.

Uehara Y, Mochizuki M, Matsuno K, Haino T, Asai A.

Biochem Biophys Res Commun. 2009 Mar 13;380(3):627-31. doi: 10.1016/j.bbrc.2009.01.137. Epub 2009 Jan 27.

PMID:
19285012
17.
18.

Mutational analysis of acute-phase response factor/Stat3 activation and dimerization.

Sasse J, Hemmann U, Schwartz C, Schniertshauer U, Heesel B, Landgraf C, Schneider-Mergener J, Heinrich PC, Horn F.

Mol Cell Biol. 1997 Aug;17(8):4677-86.

19.

Discovery of the catechol structural moiety as a Stat3 SH2 domain inhibitor by virtual screening.

Hao W, Hu Y, Niu C, Huang X, Chang CP, Gibbons J, Xu J.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):4988-92. doi: 10.1016/j.bmcl.2008.08.032. Epub 2008 Aug 14.

PMID:
18768317
20.

Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice.

Onimoe GI, Liu A, Lin L, Wei CC, Schwartz EB, Bhasin D, Li C, Fuchs JR, Li PK, Houghton P, Termuhlen A, Gross T, Lin J.

Invest New Drugs. 2012 Jun;30(3):916-26. doi: 10.1007/s10637-011-9645-1. Epub 2011 Feb 22.

PMID:
21340507
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