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Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction.

Fang XY, Chen W, Fan JT, Song R, Wang L, Gu YH, Zeng GZ, Shen Y, Wu XF, Tan NH, Xu Q, Sun Y.

Toxicol Appl Pharmacol. 2013 Feb 15;267(1):95-103. doi: 10.1016/j.taap.2012.12.010. Epub 2012 Dec 26.


Tanshinone IIA induces mitochondria dependent apoptosis in prostate cancer cells in association with an inhibition of phosphoinositide 3-kinase/AKT pathway.

Won SH, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Jung DB, Shin JM, Kwon TR, Yun SM, Lee MH, Choi SH, Lü J, Kim SH.

Biol Pharm Bull. 2010;33(11):1828-34.


Surfactin induces apoptosis in human breast cancer MCF-7 cells through a ROS/JNK-mediated mitochondrial/caspase pathway.

Cao XH, Wang AH, Wang CL, Mao DZ, Lu MF, Cui YQ, Jiao RZ.

Chem Biol Interact. 2010 Feb 12;183(3):357-62. doi: 10.1016/j.cbi.2009.11.027. Epub 2009 Nov 30.


Furanodiene, a natural product, inhibits breast cancer growth both in vitro and in vivo.

Zhong Z, Dang Y, Yuan X, Guo W, Li Y, Tan W, Cui J, Lu J, Zhang Q, Chen X, Wang Y.

Cell Physiol Biochem. 2012;30(3):778-90. doi: 10.1159/000341457. Epub 2012 Aug 2.


Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

Sunters A, Madureira PA, Pomeranz KM, Aubert M, Brosens JJ, Cook SJ, Burgering BM, Coombes RC, Lam EW.

Cancer Res. 2006 Jan 1;66(1):212-20.


Reactive oxygen species-mediated mitochondrial dysfunction is involved in apoptosis in human nasopharyngeal carcinoma CNE cells induced by Selaginella doederleinii extract.

Liu H, Peng H, Ji Z, Zhao S, Zhang Y, Wu J, Fan J, Liao J.

J Ethnopharmacol. 2011 Oct 31;138(1):184-91. doi: 10.1016/j.jep.2011.08.072. Epub 2011 Sep 8.


Platycodin D induces apoptosis in MCF-7 human breast cancer cells.

Yu JS, Kim AK.

J Med Food. 2010 Apr;13(2):298-305. doi: 10.1089/jmf.2009.1226.


Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia.

Zeng Z, Samudio IJ, Zhang W, Estrov Z, Pelicano H, Harris D, Frolova O, Hail N Jr, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M.

Cancer Res. 2006 Apr 1;66(7):3737-46.


Theaflavins target Fas/caspase-8 and Akt/pBad pathways to induce apoptosis in p53-mutated human breast cancer cells.

Lahiry L, Saha B, Chakraborty J, Adhikary A, Mohanty S, Hossain DM, Banerjee S, Das K, Sa G, Das T.

Carcinogenesis. 2010 Feb;31(2):259-68. doi: 10.1093/carcin/bgp240. Epub 2009 Dec 7.


3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner.

Gagliardi PA, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, Bussolino F, Primo L.

Neoplasia. 2012 Aug;14(8):719-31.


Anti-proliferative effect of an extract of the root of Polygonum multiflorum Thunb. on MCF-7 human breast cancer cells and the possible mechanisms.

Chen HS, Liu Y, Lin LQ, Zhao JL, Zhang CP, Jin JC, Wang L, Bai MH, Wang YC, Liu M, Shen BZ.

Mol Med Rep. 2011 Nov-Dec;4(6):1313-9. doi: 10.3892/mmr.2011.574. Epub 2011 Aug 25.


A novel cycloheptapeptide exerts strong anticancer activity via stimulation of multiple apoptotic pathways in caspase-3 deficient cancer cells.

Ubol S, Kramyu J, Masrinoul P, Kachangchaeng C, Pittayanurak P, Sophasan S, Reutrakul V.

Anticancer Res. 2007 Jul-Aug;27(4B):2473-9.


Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor.

Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS.

Mol Cancer Ther. 2008 Apr;7(4):800-8. doi: 10.1158/1535-7163.MCT-07-0434.


[Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway].

Chu ZH, Liang XH, Zhou XL, Huang RF, Zhan Qz, Jiang JW.

Zhong Xi Yi Jie He Xue Bao. 2011 May;9(5):533-8. Chinese.


Anti-tumor potential of 15,16-dihydrotanshinone I against breast adenocarcinoma through inducing G1 arrest and apoptosis.

Tsai SL, Suk FM, Wang CI, Liu DZ, Hou WC, Lin PJ, Hung LF, Liang YC.

Biochem Pharmacol. 2007 Dec 3;74(11):1575-86. Epub 2007 Aug 11.

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