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Results: 1 to 20 of 102

1.

Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy.

Ahmad A, Biersack B, Li Y, Kong D, Bao B, Schobert R, Padhye SB, Sarkar FH.

Anticancer Agents Med Chem. 2013 Sep;13(7):1002-13. Review.

PMID:
23272910
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Deregulation of PI3K/Akt/mTOR signaling pathways by isoflavones and its implication in cancer treatment.

Ahmad A, Biersack B, Li Y, Kong D, Bao B, Schobert R, Padhye SB, Sarkar FH.

Anticancer Agents Med Chem. 2013 Sep;13(7):1014-24. Review.

PMID:
23272911
[PubMed - indexed for MEDLINE]
3.

S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton.

Zhang C, Yang N, Yang CH, Ding HS, Luo C, Zhang Y, Wu MJ, Zhang XW, Shen X, Jiang HL, Meng LH, Ding J.

PLoS One. 2009;4(3):e4881. doi: 10.1371/journal.pone.0004881. Epub 2009 Mar 18.

PMID:
19293927
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Targeting mTOR: evaluating the therapeutic potential of resveratrol for cancer treatment.

Wu Y, Liu F.

Anticancer Agents Med Chem. 2013 Sep;13(7):1032-8. Review.

PMID:
23272906
[PubMed - indexed for MEDLINE]
5.

Inactivation of akt and NF-kappaB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells.

Rahman KM, Li Y, Sarkar FH.

Nutr Cancer. 2004;48(1):84-94.

PMID:
15203382
[PubMed - indexed for MEDLINE]
6.

Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.

Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A.

J Biol Chem. 2009 Feb 13;284(7):4052-61. doi: 10.1074/jbc.M805032200. Epub 2008 Dec 13.

PMID:
19074768
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Inactivation of NF-kappaB by 3,3'-diindolylmethane contributes to increased apoptosis induced by chemotherapeutic agent in breast cancer cells.

Rahman KM, Ali S, Aboukameel A, Sarkar SH, Wang Z, Philip PA, Sakr WA, Raz A.

Mol Cancer Ther. 2007 Oct;6(10):2757-65. Epub 2007 Oct 3.

PMID:
17913854
[PubMed - indexed for MEDLINE]
Free Article
8.

Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities.

Kumar A, Kumar Singh U, Chaudhary A.

Future Med Chem. 2013 May;5(7):809-29. doi: 10.4155/fmc.13.32. Review.

PMID:
23651094
[PubMed - indexed for MEDLINE]
9.

Achieving cancer cell death with PI3K/mTOR-targeted therapies.

Yea SS, Fruman DA.

Ann N Y Acad Sci. 2013 Mar;1280:15-8. doi: 10.1111/nyas.12028. Review.

PMID:
23551096
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies.

Barrett D, Brown VI, Grupp SA, Teachey DT.

Paediatr Drugs. 2012 Oct 1;14(5):299-316. doi: 10.2165/11594740-000000000-00000. Review.

PMID:
22845486
[PubMed - indexed for MEDLINE]
11.

Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs.

Markman B, Dienstmann R, Tabernero J.

Oncotarget. 2010 Nov;1(7):530-43. Review.

PMID:
21317449
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Modulatory effect of curcumin on survival of irradiated human intestinal microvascular endothelial cells: role of Akt/mTOR and NF-{kappa}B.

Rafiee P, Binion DG, Wellner M, Behmaram B, Floer M, Mitton E, Nie L, Zhang Z, Otterson MF.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G865-77. doi: 10.1152/ajpgi.00339.2009. Epub 2010 Mar 18.

PMID:
20299603
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy.

Ahmad A, Sakr WA, Rahman KM.

Curr Drug Targets. 2010 Jun;11(6):652-66. Review.

PMID:
20298156
[PubMed - indexed for MEDLINE]
14.

Baicalin induces apoptosis in leukemia HL-60/ADR cells via possible down-regulation of the PI3K/Akt signaling pathway.

Zheng J, Hu JD, Chen YY, Chen BY, Huang Y, Zheng ZH, Liu TB.

Asian Pac J Cancer Prev. 2012;13(4):1119-24.

PMID:
22799292
[PubMed - indexed for MEDLINE]
Free Article
15.

Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin.

Syed DN, Adhami VM, Khan MI, Mukhtar H.

Anticancer Agents Med Chem. 2013 Sep;13(7):995-1001. Review.

PMID:
23293889
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

NF-κB participates in chemokine receptor 7-mediated cell survival in metastatic squamous cell carcinoma of the head and neck.

Liu FY, Zhao ZJ, Li P, Ding X, Guo N, Yang LL, Zong ZH, Sun CF.

Oncol Rep. 2011 Feb;25(2):383-91. doi: 10.3892/or.2010.1090. Epub 2010 Dec 9.

PMID:
21165563
[PubMed - indexed for MEDLINE]
17.

Natural products targeting autophagy via the PI3K/Akt/mTOR pathway as anticancer agents.

Sun H, Wang Z, Yakisich JS.

Anticancer Agents Med Chem. 2013 Sep;13(7):1048-56. Review.

PMID:
23293890
[PubMed - indexed for MEDLINE]
18.

Novel approaches for molecular targeted therapy of breast cancer: interfering with PI3K/AKT/mTOR signaling.

Grunt TW, Mariani GL.

Curr Cancer Drug Targets. 2013 Feb;13(2):188-204. Review.

PMID:
23215720
[PubMed - indexed for MEDLINE]
19.

Piceatannol suppresses breast cancer cell invasion through the inhibition of MMP-9: involvement of PI3K/AKT and NF-κB pathways.

Ko HS, Lee HJ, Kim SH, Lee EO.

J Agric Food Chem. 2012 Apr 25;60(16):4083-9. doi: 10.1021/jf205171g. Epub 2012 Apr 13.

PMID:
22480333
[PubMed - indexed for MEDLINE]
20.

Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway.

Ching CB, Hansel DE.

Lab Invest. 2010 Oct;90(10):1406-14. doi: 10.1038/labinvest.2010.133. Epub 2010 Jul 26. Review.

PMID:
20661228
[PubMed - indexed for MEDLINE]
Free Article

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