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Items: 1 to 20 of 100

1.

Exploring key orientations at protein-protein interfaces with small molecule probes.

Ko E, Raghuraman A, Perez LM, Ioerger TR, Burgess K.

J Am Chem Soc. 2013 Jan 9;135(1):167-73. doi: 10.1021/ja3067258. Epub 2012 Dec 27.

2.

Hot spot-based design of small-molecule inhibitors for protein-protein interactions.

Guo W, Wisniewski JA, Ji H.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2546-54. doi: 10.1016/j.bmcl.2014.03.095. Epub 2014 Apr 5. Erratum in: Bioorg Med Chem Lett. 2014 Aug 1;24(15):3652.

3.

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

Thiel P, Kaiser M, Ottmann C.

Angew Chem Int Ed Engl. 2012 Feb 27;51(9):2012-8. doi: 10.1002/anie.201107616. Epub 2012 Feb 3. Review.

PMID:
22308055
4.

Triterpenes as potential dimerization inhibitors of HIV-1 protease.

Quéré L, Wenger T, Schramm HJ.

Biochem Biophys Res Commun. 1996 Oct 14;227(2):484-8.

PMID:
8967903
5.

Targeting protein-protein interactions and fragment-based drug discovery.

Valkov E, Sharpe T, Marsh M, Greive S, Hyvönen M.

Top Curr Chem. 2012;317:145-79. doi: 10.1007/128_2011_265. Review.

PMID:
22006238
6.

Protein promiscuity: drug resistance and native functions--HIV-1 case.

Fernández A, Tawfik DS, Berkhout B, Sanders R, Kloczkowski A, Sen T, Jernigan B.

J Biomol Struct Dyn. 2005 Jun;22(6):615-24.

PMID:
15842167
7.
9.

A multifaceted secondary structure mimic based on piperidine-piperidinones.

Xin D, Perez LM, Ioerger TR, Burgess K.

Angew Chem Int Ed Engl. 2014 Apr 1;53(14):3594-8. doi: 10.1002/anie.201400927. Epub 2014 Mar 3.

10.
11.

Kinetics of the dimerization of retroviral proteases: the "fireman's grip" and dimerization.

Ingr M, Uhlíková T, Strísovský K, Majerová E, Konvalinka J.

Protein Sci. 2003 Oct;12(10):2173-82.

12.
13.

Development of low molecular weight HIV-1 protease dimerization inhibitors.

Hwang YS, Chmielewski J.

J Med Chem. 2005 Mar 24;48(6):2239-42.

PMID:
15771466
14.

Folded monomer of HIV-1 protease.

Ishima R, Ghirlando R, Tözsér J, Gronenborn AM, Torchia DA, Louis JM.

J Biol Chem. 2001 Dec 28;276(52):49110-6. Epub 2001 Oct 11.

15.

Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease.

Specker E, Böttcher J, Brass S, Heine A, Lilie H, Schoop A, Müller G, Griebenow N, Klebe G.

ChemMedChem. 2006 Jan;1(1):106-17.

PMID:
16892342
16.

Small Molecule Probes That Perturb A Protein-protein Interface In Antithrombin.

Xin D, Holzenburg A, Burgess K.

Chem Sci. 2014 Dec 1;5(12):4914-4921.

17.

Revisiting monomeric HIV-1 protease. Characterization and redesign for improved properties.

Louis JM, Ishima R, Nesheiwat I, Pannell LK, Lynch SM, Torchia DA, Gronenborn AM.

J Biol Chem. 2003 Feb 21;278(8):6085-92. Epub 2002 Dec 4.

19.

The structural stability of the HIV-1 protease.

Todd MJ, Semo N, Freire E.

J Mol Biol. 1998 Oct 23;283(2):475-88.

PMID:
9769219
20.

Alkyl hydroxybenzoic acid derivatives that inhibit HIV-1 protease dimerization.

Flausino OA Jr, Dufau L, Regasini LO, Petrônio MS, Silva DH, Rose T, Bolzani VS, Reboud-Ravaux M.

Curr Med Chem. 2012;19(26):4534-40.

PMID:
22963666
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