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Results: 1 to 20 of 103

1.

ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase.

Zhou H, Sun L, Yang XL, Schimmel P.

Nature. 2013 Feb 7;494(7435):121-4. doi: 10.1038/nature11774. Epub 2012 Dec 23.

PMID:
23263184
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.

Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M.

Nat Chem Biol. 2012 Feb 12;8(3):311-7. doi: 10.1038/nchembio.790.

PMID:
22327401
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Conformational changes in human prolyl-tRNA synthetase upon binding of the substrates proline and ATP and the inhibitor halofuginone.

Son J, Lee EH, Park M, Kim JH, Kim J, Kim S, Jeon YH, Hwang KY.

Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2136-45. doi: 10.1107/S0907444913020556. Epub 2013 Sep 20.

PMID:
24100331
[PubMed - indexed for MEDLINE]
4.
5.

An isolated class II aminoacyl-tRNA synthetase insertion domain is functional in amino acid editing.

Wong FC, Beuning PJ, Silvers C, Musier-Forsyth K.

J Biol Chem. 2003 Dec 26;278(52):52857-64. Epub 2003 Oct 6.

PMID:
14530268
[PubMed - indexed for MEDLINE]
Free Article
6.

Transfer RNA modulates the editing mechanism used by class II prolyl-tRNA synthetase.

Splan KE, Ignatov ME, Musier-Forsyth K.

J Biol Chem. 2008 Mar 14;283(11):7128-34. doi: 10.1074/jbc.M709902200. Epub 2008 Jan 7.

PMID:
18180290
[PubMed - indexed for MEDLINE]
Free Article
7.

New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.

Takaya Y, Tasaka H, Chiba T, Uwai K, Tanitsu M, Kim HS, Wataya Y, Miura M, Takeshita M, Oshima Y.

J Med Chem. 1999 Aug 12;42(16):3163-6.

PMID:
10447961
[PubMed - indexed for MEDLINE]
8.

Aminoacyl-tRNA synthetases.

Cusack S.

Curr Opin Struct Biol. 1997 Dec;7(6):881-9. Review.

PMID:
9434910
[PubMed - indexed for MEDLINE]
9.

The crystal structure of asparaginyl-tRNA synthetase from Thermus thermophilus and its complexes with ATP and asparaginyl-adenylate: the mechanism of discrimination between asparagine and aspartic acid.

Berthet-Colominas C, Seignovert L, Härtlein M, Grotli M, Cusack S, Leberman R.

EMBO J. 1998 May 15;17(10):2947-60.

PMID:
9582288
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Two classes of tRNA synthetases suggested by sterically compatible dockings on tRNA acceptor stem.

Ribas de Pouplana L, Schimmel P.

Cell. 2001 Jan 26;104(2):191-3. No abstract available.

PMID:
11269237
[PubMed - indexed for MEDLINE]
Free Article
11.

Yeast seryl tRNA synthetase: interactions between the ATP binding site and the sites for tRNASer and L-serine.

Pachmann U, Zachau HG.

Nucleic Acids Res. 1978 Mar;5(3):975-85.

PMID:
417297
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

How glutaminyl-tRNA synthetase selects glutamine.

Rath VL, Silvian LF, Beijer B, Sproat BS, Steitz TA.

Structure. 1998 Apr 15;6(4):439-49.

PMID:
9562563
[PubMed - indexed for MEDLINE]
13.

Crystallographic studies on multiple conformational states of active-site loops in pyrrolysyl-tRNA synthetase.

Yanagisawa T, Ishii R, Fukunaga R, Kobayashi T, Sakamoto K, Yokoyama S.

J Mol Biol. 2008 May 2;378(3):634-52. doi: 10.1016/j.jmb.2008.02.045. Epub 2008 Feb 29.

PMID:
18387634
[PubMed - indexed for MEDLINE]
14.

Amino acid discrimination by a class I aminoacyl-tRNA synthetase specified by negative determinants.

Bullock TL, Uter N, Nissan TA, Perona JJ.

J Mol Biol. 2003 Apr 25;328(2):395-408.

PMID:
12691748
[PubMed - indexed for MEDLINE]
15.

The class II aminoacyl-tRNA synthetases and their active site: evolutionary conservation of an ATP binding site.

Eriani G, Cavarelli J, Martin F, Ador L, Rees B, Thierry JC, Gangloff J, Moras D.

J Mol Evol. 1995 May;40(5):499-508.

PMID:
7783225
[PubMed - indexed for MEDLINE]
16.

Synthesis and comparison of antimalarial activity of febrifugine derivatives including halofuginone.

Samant BS, Sukhthankar MG.

Med Chem. 2009 May;5(3):293-300.

PMID:
19442220
[PubMed - indexed for MEDLINE]
17.

Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases.

Cusack S, Härtlein M, Leberman R.

Nucleic Acids Res. 1991 Jul 11;19(13):3489-98.

PMID:
1852601
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Chemical modification and site-directed mutagenesis of the single cysteine in motif 3 of class II Escherichia coli prolyl-tRNA synthetase.

Stehlin C, Heacock DH 2nd, Liu H, Musier-Forsyth K.

Biochemistry. 1997 Mar 11;36(10):2932-8.

PMID:
9062123
[PubMed - indexed for MEDLINE]
19.

tRNA(Pro) anticodon recognition by Thermus thermophilus prolyl-tRNA synthetase.

Cusack S, Yaremchuk A, Krikliviy I, Tukalo M.

Structure. 1998 Jan 15;6(1):101-8.

PMID:
9493271
[PubMed - indexed for MEDLINE]
20.

The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases.

Kamtekar S, Kennedy WD, Wang J, Stathopoulos C, Söll D, Steitz TA.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1673-8. Epub 2003 Feb 10.

PMID:
12578991
[PubMed - indexed for MEDLINE]
Free PMC Article

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