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Results: 1 to 20 of 94

1.

Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo.

Li X, Liu S, Huang H, Liu N, Zhao C, Liao S, Yang C, Liu Y, Zhao C, Li S, Lu X, Liu C, Guan L, Zhao K, Shi X, Song W, Zhou P, Dong X, Guo H, Wen G, Zhang C, Jiang L, Ma N, Li B, Wang S, Tan H, Wang X, Dou QP, Liu J.

Cell Rep. 2013 Jan 31;3(1):211-22. doi: 10.1016/j.celrep.2012.11.023. Epub 2012 Dec 21.

PMID:
23260670
[PubMed - indexed for MEDLINE]
Free Article
2.

The combination of proteasome inhibitors bortezomib and gambogic acid triggers synergistic cytotoxicity in vitro but not in vivo.

Liu N, Huang H, Xu L, Hua X, Li X, Liu S, Yang C, Zhao C, Zhao C, Li S, Dou QP, Liu J.

Toxicol Lett. 2014 Jan 30;224(3):333-40. doi: 10.1016/j.toxlet.2013.11.021. Epub 2013 Nov 26.

PMID:
24291039
[PubMed - indexed for MEDLINE]
3.

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system.

Felth J, Lesiak-Mieczkowska K, D'Arcy P, Haglund C, Gullbo J, Larsson R, Linder S, Bohlin L, Fryknäs M, Rickardson L.

Invest New Drugs. 2013 Jun;31(3):587-98. doi: 10.1007/s10637-012-9902-y. Epub 2012 Nov 20.

PMID:
23179339
[PubMed - indexed for MEDLINE]
4.

HDAC inhibitor L-carnitine and proteasome inhibitor bortezomib synergistically exert anti-tumor activity in vitro and in vivo.

Huang H, Liu N, Yang C, Liao S, Guo H, Zhao K, Li X, Liu S, Guan L, Liu C, Xu L, Zhang C, Song W, Li B, Tang P, Dou QP, Liu J.

PLoS One. 2012;7(12):e52576. doi: 10.1371/journal.pone.0052576. Epub 2012 Dec 20.

PMID:
23285100
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Gambogic acid enhances proteasome inhibitor-induced anticancer activity.

Huang H, Chen D, Li S, Li X, Liu N, Lu X, Liu S, Zhao K, Zhao C, Guo H, Yang C, Zhou P, Dong X, Zhang C, Guanmei, Dou QP, Liu J.

Cancer Lett. 2011 Feb 28;301(2):221-8. doi: 10.1016/j.canlet.2010.12.015. Epub 2011 Jan 7.

PMID:
21216092
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation.

Liu N, Huang H, Liu S, Li X, Yang C, Dou QP, Liu J.

Toxicol In Vitro. 2014 Apr;28(3):419-25. doi: 10.1016/j.tiv.2013.12.008. Epub 2013 Dec 27.

PMID:
24373880
[PubMed - in process]
7.

Antitumor effects of proteasome inhibition in anaplastic thyroid carcinoma.

Altmann A, Markert A, Askoxylakis V, Schöning T, Jesenofsky R, Eisenhut M, Haberkorn U.

J Nucl Med. 2012 Nov;53(11):1764-71. doi: 10.2967/jnumed.111.101295. Epub 2012 Oct 10.

PMID:
23055533
[PubMed - indexed for MEDLINE]
Free Article
8.

Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives.

Liu Y, Qian K, Wang CY, Chen CH, Yang X, Lee KH.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7530-3. doi: 10.1016/j.bmcl.2012.10.041. Epub 2012 Oct 16.

PMID:
23122524
[PubMed - indexed for MEDLINE]
9.

Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells.

Liu CY, Shiau CW, Kuo HY, Huang HP, Chen MH, Tzeng CH, Chen KF.

Haematologica. 2013 May;98(5):729-38. doi: 10.3324/haematol.2011.050187. Epub 2012 Sep 14.

PMID:
22983581
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP.

Wang J, Zhao Q, Qi Q, Gu HY, Rong JJ, Mu R, Zou MJ, Tao L, You QD, Guo QL.

J Cell Biochem. 2011 Feb;112(2):509-19. doi: 10.1002/jcb.22941.

PMID:
21268072
[PubMed - indexed for MEDLINE]
11.

Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells.

Komatsu S, Moriya S, Che XF, Yokoyama T, Kohno N, Miyazawa K.

Biochem Biophys Res Commun. 2013 Jul 19;437(1):41-7. doi: 10.1016/j.bbrc.2013.06.032. Epub 2013 Jun 18.

PMID:
23792097
[PubMed - indexed for MEDLINE]
12.

Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells.

Li R, Chen Y, Zeng LL, Shu WX, Zhao F, Wen L, Liu Y.

Toxicology. 2009 Aug 3;262(2):98-105. doi: 10.1016/j.tox.2009.04.059. Epub 2009 May 9.

PMID:
19433130
[PubMed - indexed for MEDLINE]
13.

Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base-copper complexes.

Zuo J, Bi C, Fan Y, Buac D, Nardon C, Daniel KG, Dou QP.

J Inorg Biochem. 2013 Jan;118:83-93. doi: 10.1016/j.jinorgbio.2012.10.006. Epub 2012 Oct 15.

PMID:
23142973
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Withaferin A inhibits the proteasome activity in mesothelioma in vitro and in vivo.

Yang H, Wang Y, Cheryan VT, Wu W, Cui CQ, Polin LA, Pass HI, Dou QP, Rishi AK, Wali A.

PLoS One. 2012;7(8):e41214. doi: 10.1371/journal.pone.0041214. Epub 2012 Aug 17.

PMID:
22912669
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Proteasome inhibition with bortezomib induces cell death in GBM stem-like cells and temozolomide-resistant glioma cell lines, but stimulates GBM stem-like cells' VEGF production and angiogenesis.

Bota DA, Alexandru D, Keir ST, Bigner D, Vredenburgh J, Friedman HS.

J Neurosurg. 2013 Dec;119(6):1415-23. doi: 10.3171/2013.7.JNS1323. Epub 2013 Oct 4.

PMID:
24093630
[PubMed - indexed for MEDLINE]
16.

Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53.

Rong JJ, Hu R, Qi Q, Gu HY, Zhao Q, Wang J, Mu R, You QD, Guo QL.

Cancer Lett. 2009 Oct 18;284(1):102-12. doi: 10.1016/j.canlet.2009.04.011. Epub 2009 May 9.

PMID:
19428175
[PubMed - indexed for MEDLINE]
17.

Therapeutic enhancement of ER stress by insulin-like growth factor I sensitizes myeloma cells to proteasomal inhibitors.

Tagoug I, Jordheim LP, Herveau S, Matera EL, Huber AL, Chettab K, Manié S, Dumontet C.

Clin Cancer Res. 2013 Jul 1;19(13):3556-66. doi: 10.1158/1078-0432.CCR-12-3134. Epub 2013 May 14.

PMID:
23674497
[PubMed - indexed for MEDLINE]
Free Article
18.

Studies on chemical-structure modification and structure-activity relationship of gambogic acid derivatives at carbon(34).

Zhang XJ, Li X, Yang YR, Sun HP, Gao Y, Zhang L, Wang JX, Guo QL, You QD.

Chem Biodivers. 2012 Oct;9(10):2295-308. doi: 10.1002/cbdv.201200081.

PMID:
23081928
[PubMed - indexed for MEDLINE]
19.

Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.

Anchoori RK, Khan SR, Sueblinvong T, Felthauser A, Iizuka Y, Gavioli R, Destro F, Isaksson Vogel R, Peng S, Roden RB, Bazzaro M.

PLoS One. 2011;6(8):e23888. doi: 10.1371/journal.pone.0023888. Epub 2011 Aug 31.

PMID:
21909374
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cells.

Zhou B, Zuo Y, Li B, Wang H, Liu H, Wang X, Qiu X, Hu Y, Wen S, Du J, Bu X.

Mol Cancer Ther. 2013 Aug;12(8):1381-92. doi: 10.1158/1535-7163.MCT-12-1057. Epub 2013 May 21.

PMID:
23696216
[PubMed - indexed for MEDLINE]
Free Article

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