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Results: 1 to 20 of 107

1.

Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5.

Olsson RI, Jacobson I, Boström J, Fex T, Björe A, Olsson C, Sundell J, Gran U, Öhrn A, Nordin A, Gyll J, Thorstensson M, Hayen A, Aplander K, Hidestål O, Jiang F, Linhardt G, Forsström E, Collins T, Sundqvist M, Lindhardt E, Åstrand A, Löfberg B.

Bioorg Med Chem Lett. 2013 Feb 1;23(3):706-10. doi: 10.1016/j.bmcl.2012.11.098. Epub 2012 Dec 3.

PMID:
23260347
[PubMed - indexed for MEDLINE]
2.

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers.

Lloyd J, Finlay HJ, Vacarro W, Hyunh T, Kover A, Bhandaru R, Yan L, Atwal K, Conder ML, Jenkins-West T, Shi H, Huang C, Li D, Sun H, Levesque P.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1436-9. doi: 10.1016/j.bmcl.2009.12.085. Epub 2010 Jan 4.

PMID:
20097068
[PubMed - indexed for MEDLINE]
3.

Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel.

Gross MF, Beaudoin S, McNaughton-Smith G, Amato GS, Castle NA, Huang C, Zou A, Yu W.

Bioorg Med Chem Lett. 2007 May 15;17(10):2849-53. Epub 2007 Feb 27.

PMID:
17350840
[PubMed - indexed for MEDLINE]
4.

Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel.

Peukert S, Brendel J, Pirard B, Strübing C, Kleemann HW, Böhme T, Hemmerle H.

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2823-7.

PMID:
15125940
[PubMed - indexed for MEDLINE]
5.

High-throughput analysis of drug binding interactions for the human cardiac channel, Kv1.5.

Karczewski J, Kiss L, Kane SA, Koblan KS, Lynch RJ, Spencer RH.

Biochem Pharmacol. 2009 Jan 15;77(2):177-85. doi: 10.1016/j.bcp.2008.09.035. Epub 2008 Oct 8.

PMID:
18955031
[PubMed - indexed for MEDLINE]
6.

Novel peptidyl phosphorus derivatives as inhibitors of human calpain I.

Tao M, Bihovsky R, Wells GJ, Mallamo JP.

J Med Chem. 1998 Sep 24;41(20):3912-6.

PMID:
9748367
[PubMed - indexed for MEDLINE]
7.

Lactam sulfonamides as potent inhibitors of the Kv1.5 potassium ion channel.

Olsson RI, Jacobson I, Iliefski T, Boström J, Davidsson Ö, Fjellström O, Björe A, Olsson C, Sundell J, Gran U, Gyll J, Malmberg J, Hidestål O, Emtenäs H, Svensson T, Yuan ZQ, Strandlund G, Åstrand A, Lindhardt E, Linhardt G, Forsström E, Högberg Å, Persson F, Andersson B, Rönnborg A, Löfberg B.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1269-73. doi: 10.1016/j.bmcl.2014.01.067. Epub 2014 Jan 30.

PMID:
24513046
[PubMed - indexed for MEDLINE]
8.

Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current.

Lagrutta A, Wang J, Fermini B, Salata JJ.

J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63. Epub 2006 Mar 7.

PMID:
16522807
[PubMed - indexed for MEDLINE]
Free Article
9.

Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and binding mode.

Strutz-Seebohm N, Gutcher I, Decher N, Steinmeyer K, Lang F, Seebohm G.

Cell Physiol Biochem. 2007;20(6):791-800.

PMID:
17982261
[PubMed - indexed for MEDLINE]
10.

Kv1.5 blockers for the treatment of atrial fibrillation: approaches to optimization of potency and selectivity and translation to in vivo pharmacology.

Bilodeau MT, Trotter BW.

Curr Top Med Chem. 2009;9(5):436-51. Review.

PMID:
19519460
[PubMed - indexed for MEDLINE]
11.

Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.

Gross MF, Castle NA, Zou A, Wickenden AD, Yu W, Spear KL.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):3063-6. doi: 10.1016/j.bmcl.2009.04.002. Epub 2009 Apr 8.

PMID:
19398199
[PubMed - indexed for MEDLINE]
12.

Synthesis and glycogen phosphorylase inhibitory activity of N-(beta-D-glucopyranosyl)amides possessing 1,4-benzodioxane moiety.

Czakó Z, Juhász L, Kenéz A, Czifrák K, Somsák L, Docsa T, Gergely P, Antus S.

Bioorg Med Chem. 2009 Sep 15;17(18):6738-41. doi: 10.1016/j.bmc.2009.07.052. Epub 2009 Jul 25.

PMID:
19703777
[PubMed - indexed for MEDLINE]
13.

Identification, synthesis, and activity of novel blockers of the voltage-gated potassium channel Kv1.5.

Peukert S, Brendel J, Pirard B, Brüggemann A, Below P, Kleemann HW, Hemmerle H, Schmidt W.

J Med Chem. 2003 Feb 13;46(4):486-98.

PMID:
12570371
[PubMed - indexed for MEDLINE]
14.

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Guo X, Yang Q, Xu J, Zhang L, Chu H, Yu P, Zhu Y, Wei J, Chen W, Zhang Y, Zhang X, Sun H, Tang Y, You Q.

Bioorg Med Chem. 2013 Nov 1;21(21):6466-76. doi: 10.1016/j.bmc.2013.08.041. Epub 2013 Aug 31.

PMID:
24071446
[PubMed - indexed for MEDLINE]
15.

In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide.

Stump GL, Wallace AA, Regan CP, Lynch JJ Jr.

J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7. Epub 2005 Sep 12.

PMID:
16157659
[PubMed - indexed for MEDLINE]
Free Article
16.

In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate.

Regan CP, Wallace AA, Cresswell HK, Atkins CL, Lynch JJ Jr.

J Pharmacol Exp Ther. 2006 Feb;316(2):727-32. Epub 2005 Oct 21.

PMID:
16243963
[PubMed - indexed for MEDLINE]
Free Article
17.

Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).

Yang MG, Xiao Z, Shi Q, Cherney RJ, Tebben AJ, De Lucca GV, Santella JB 3rd, Mo R, Cvijic ME, Zhao Q, Barrish JC, Carter PH.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1384-7. doi: 10.1016/j.bmcl.2011.12.057. Epub 2011 Dec 16.

PMID:
22225639
[PubMed - indexed for MEDLINE]
18.

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers.

Wu S, Fluxe A, Janusz JM, Sheffer JB, Browning G, Blass B, Cobum K, Hedges R, Murawsky M, Fang B, Fadayel GM, Hare M, Djandjighian L.

Bioorg Med Chem Lett. 2006 Nov 15;16(22):5859-63. Epub 2006 Aug 30.

PMID:
16942874
[PubMed - indexed for MEDLINE]
19.

Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation.

Blass BE, Coburn K, Lee W, Fairweather N, Fluxe A, Wu S, Janusz JM, Murawsky M, Fadayel GM, Fang B, Hare M, Ridgeway J, White R, Jackson C, Djandjighian L, Hedges R, Wireko FC, Ritter AL.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4629-32. Epub 2006 Jun 21.

PMID:
16793267
[PubMed - indexed for MEDLINE]
20.

Ruthenium-catalyzed hydrophosphinylative cyclization of 1,6-diynes. Stereoselective synthesis of exocyclic 1,3-dienylphosphine oxides.

Yamamoto Y, Fukatsu K, Nishiyama H.

Chem Commun (Camb). 2012 Aug 18;48(64):7985-7. doi: 10.1039/c2cc34044e. Epub 2012 Jul 4.

PMID:
22763601
[PubMed - indexed for MEDLINE]
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