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Results: 1 to 20 of 105

1.

Pharmacokinetic and pharmacodynamic modeling to determine the dose of ST-246 to protect against smallpox in humans.

Leeds JM, Fenneteau F, Gosselin NH, Mouksassi MS, Kassir N, Marier JF, Chen Y, Grosenbach D, Frimm AE, Honeychurch KM, Chinsangaram J, Tyavanagimatt SR, Hruby DE, Jordan R.

Antimicrob Agents Chemother. 2013 Mar;57(3):1136-43. doi: 10.1128/AAC.00959-12. Epub 2012 Dec 17.

PMID:
23254433
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.

Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, Chinsangaram J, Hruby DE, Huggins J.

Antimicrob Agents Chemother. 2009 May;53(5):1817-22. doi: 10.1128/AAC.01596-08. Epub 2009 Feb 17.

PMID:
19223621
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection.

Duraffour S, Andrei G, Snoeck R.

IDrugs. 2010 Mar;13(3):181-91. Review.

PMID:
20191435
[PubMed - indexed for MEDLINE]
4.

Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection.

Stittelaar KJ, Neyts J, Naesens L, van Amerongen G, van Lavieren RF, HolĂ˝ A, De Clercq E, Niesters HG, Fries E, Maas C, Mulder PG, van der Zeijst BA, Osterhaus AD.

Nature. 2006 Feb 9;439(7077):745-8. Epub 2005 Dec 11.

PMID:
16341204
[PubMed - indexed for MEDLINE]
5.

In vitro efficacy of ST246 against smallpox and monkeypox.

Smith SK, Olson VA, Karem KL, Jordan R, Hruby DE, Damon IK.

Antimicrob Agents Chemother. 2009 Mar;53(3):1007-12. doi: 10.1128/AAC.01044-08. Epub 2008 Dec 15.

PMID:
19075062
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.

Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K, Damon IK, Byrd CM, Bolken TC, Jordan R, Hruby D.

Antimicrob Agents Chemother. 2009 Jun;53(6):2620-5. doi: 10.1128/AAC.00021-09. Epub 2009 Apr 6.

PMID:
19349521
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus.

Stabenow J, Buller RM, Schriewer J, West C, Sagartz JE, Parker S.

J Virol. 2010 Apr;84(8):3909-20. doi: 10.1128/JVI.02012-09. Epub 2010 Feb 3.

PMID:
20130052
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Efficacy of tecovirimat (ST-246) in nonhuman primates infected with variola virus (Smallpox).

Mucker EM, Goff AJ, Shamblin JD, Grosenbach DW, Damon IK, Mehal JM, Holman RC, Carroll D, Gallardo N, Olson VA, Clemmons CJ, Hudson P, Hruby DE.

Antimicrob Agents Chemother. 2013 Dec;57(12):6246-53. doi: 10.1128/AAC.00977-13. Epub 2013 Oct 7.

PMID:
24100494
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Tecovirimat for smallpox infections.

Bolken TC, Hruby DE.

Drugs Today (Barc). 2010 Feb;46(2):109-17. doi: 10.1358/dot.2010.46.2.1437244.

PMID:
20393639
[PubMed - indexed for MEDLINE]
10.

Evaluation of disease and viral biomarkers as triggers for therapeutic intervention in respiratory mousepox - an animal model of smallpox.

Parker S, Chen NG, Foster S, Hartzler H, Hembrador E, Hruby D, Jordan R, Lanier R, Painter G, Painter W, Sagartz JE, Schriewer J, Mark Buller R.

Antiviral Res. 2012 Apr;94(1):44-53. doi: 10.1016/j.antiviral.2012.02.005. Epub 2012 Feb 18.

PMID:
22381921
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Molecule of the month. Tecovirimat.

[No authors listed]

Drug News Perspect. 2008 Nov;21(9):517. No abstract available.

PMID:
19180269
[PubMed - indexed for MEDLINE]
12.

ST-246 inhibits in vivo poxvirus dissemination, virus shedding, and systemic disease manifestation.

Berhanu A, King DS, Mosier S, Jordan R, Jones KF, Hruby DE, Grosenbach DW.

Antimicrob Agents Chemother. 2009 Dec;53(12):4999-5009. doi: 10.1128/AAC.00678-09. Epub 2009 Sep 14.

PMID:
19752270
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Efficacy of the antipoxvirus compound ST-246 for treatment of severe orthopoxvirus infection.

Sbrana E, Jordan R, Hruby DE, Mateo RI, Xiao SY, Siirin M, Newman PC, DA Rosa AP, Tesh RB.

Am J Trop Med Hyg. 2007 Apr;76(4):768-73.

PMID:
17426185
[PubMed - indexed for MEDLINE]
Free Article
14.

Experimental infection of cynomolgus macaques (Macaca fascicularis) with aerosolized monkeypox virus.

Nalca A, Livingston VA, Garza NL, Zumbrun EE, Frick OM, Chapman JL, Hartings JM.

PLoS One. 2010 Sep 20;5(9). pii: e12880. doi: 10.1371/journal.pone.0012880.

PMID:
20862223
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Effective antiviral treatment of systemic orthopoxvirus disease: ST-246 treatment of prairie dogs infected with monkeypox virus.

Smith SK, Self J, Weiss S, Carroll D, Braden Z, Regnery RL, Davidson W, Jordan R, Hruby DE, Damon IK.

J Virol. 2011 Sep;85(17):9176-87. doi: 10.1128/JVI.02173-10. Epub 2011 Jun 22.

PMID:
21697474
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections.

Baker RO, Bray M, Huggins JW.

Antiviral Res. 2003 Jan;57(1-2):13-23.

PMID:
12615299
[PubMed - indexed for MEDLINE]
17.

Infection of cynomolgus macaques with a recombinant monkeypox virus encoding green fluorescent protein.

Goff A, Mucker E, Raymond J, Fisher R, Bray M, Hensley L, Paragas J.

Arch Virol. 2011 Oct;156(10):1877-81. doi: 10.1007/s00705-011-1065-1. Epub 2011 Aug 4.

PMID:
21814864
[PubMed - indexed for MEDLINE]
18.

Experimental infection of an African dormouse (Graphiurus kelleni) with monkeypox virus.

Schultz DA, Sagartz JE, Huso DL, Buller RM.

Virology. 2009 Jan 5;383(1):86-92. doi: 10.1016/j.virol.2008.09.025. Epub 2008 Nov 1.

PMID:
18977501
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route.

Johnson RF, Dyall J, Ragland DR, Huzella L, Byrum R, Jett C, St Claire M, Smith AL, Paragas J, Blaney JE, Jahrling PB.

J Virol. 2011 Mar;85(5):2112-25. doi: 10.1128/JVI.01931-10. Epub 2010 Dec 8.

PMID:
21147922
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Smallpox research activities: U.S. interagency collaboration, 2001.

LeDuc JW, Damon I, Relman DA, Huggins J, Jahrling PB.

Emerg Infect Dis. 2002 Jul;8(7):743-5. No abstract available.

PMID:
12095449
[PubMed - indexed for MEDLINE]
Free PMC Article

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