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Items: 1 to 20 of 108

1.

The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.

Downes MT, Mehla J, Ananthaswamy N, Wakschlag A, Lamonde M, Dine E, Ambudkar SV, Golin J.

Antimicrob Agents Chemother. 2013 Feb;57(2):1025-34. doi: 10.1128/AAC.02133-12. Epub 2012 Dec 17.

2.

Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.

Sauna ZE, Bohn SS, Rutledge R, Dougherty MP, Cronin S, May L, Xia D, Ambudkar SV, Golin J.

J Biol Chem. 2008 Dec 12;283(50):35010-22. doi: 10.1074/jbc.M806446200. Epub 2008 Oct 8.

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4.

The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle.

Furman C, Mehla J, Ananthaswamy N, Arya N, Kulesh B, Kovach I, Ambudkar SV, Golin J.

J Biol Chem. 2013 Oct 18;288(42):30420-31. doi: 10.1074/jbc.M113.494682. Epub 2013 Sep 9.

5.

Functional analysis of an ATP-binding cassette transporter protein from Aspergillus fumigatus by heterologous expression in Saccharomyces cerevisiae.

Paul S, Moye-Rowley WS.

Fungal Genet Biol. 2013 Aug;57:85-91. doi: 10.1016/j.fgb.2013.06.004. Epub 2013 Jun 21.

6.

A mutation in intracellular loop 4 affects the drug-efflux activity of the yeast multidrug resistance ABC transporter Pdr5p.

Guo X, Li J, Wang T, Liu Z, Chen X, Li Y, Gu Z, Mao X, Guan W, Li Y.

PLoS One. 2012;7(1):e29520. doi: 10.1371/journal.pone.0029520. Epub 2012 Jan 6.

7.

The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Ananthaswamy N, Rutledge R, Sauna ZE, Ambudkar SV, Dine E, Nelson E, Xia D, Golin J.

Biochemistry. 2010 Jun 1;49(21):4440-9. doi: 10.1021/bi100394j.

8.
9.

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.

Ernst R, Kueppers P, Klein CM, Schwarzmueller T, Kuchler K, Schmitt L.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5069-74. doi: 10.1073/pnas.0800191105. Epub 2008 Mar 20.

10.
11.

Salicylic acid resistance is conferred by a novel YRR1 mutation in Saccharomyces cerevisiae.

Kodo N, Matsuda T, Doi S, Munakata H.

Biochem Biophys Res Commun. 2013 Apr 26;434(1):42-7. doi: 10.1016/j.bbrc.2013.03.069. Epub 2013 Mar 30.

PMID:
23545261
12.

Pdr5-mediated multidrug resistance requires the CPY-vacuolar sorting protein Vps3: are xenobiotic compounds routed from the vacuole to plasma membrane transporters for efflux?

Rutledge RM, Ghislain M, Mullins JM, de Thozée CP, Golin J.

Mol Genet Genomics. 2008 Jun;279(6):573-83. doi: 10.1007/s00438-008-0334-5. Epub 2008 Mar 8.

PMID:
18327613
13.

The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3.

Mahé Y, Parle-McDermott A, Nourani A, Delahodde A, Lamprecht A, Kuchler K.

Mol Microbiol. 1996 Apr;20(1):109-17.

PMID:
8861209
14.

Mutations adjacent to the end of transmembrane helices 6 and 7 independently affect drug efflux capacity of yeast ABC transporter Pdr5p.

Chen Z, Li J, Wang W, Guo X, Li Y, Mao X, Chen X, Guan W.

Biochim Biophys Acta. 2014 Mar;1838(3):932-9. doi: 10.1016/j.bbamem.2013.12.002. Epub 2013 Dec 12. Erratum in: Biochim Biophys Acta. 2014 Jul;1838(7):1910.

15.

Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae.

Coste AT, Ramsdale M, Ischer F, Sanglard D.

Microbiology. 2008 May;154(Pt 5):1491-501. doi: 10.1099/mic.0.2007/016063-0.

PMID:
18451058
16.

Generating symmetry in the asymmetric ATP-binding cassette (ABC) transporter Pdr5 from Saccharomyces cerevisiae.

Gupta RP, Kueppers P, Hanekop N, Schmitt L.

J Biol Chem. 2014 May 30;289(22):15272-9. doi: 10.1074/jbc.M114.553065. Epub 2014 Apr 14.

17.

Vmr 1p is a novel vacuolar multidrug resistance ABC transporter in Saccharomyces cerevisiae.

Wawrzycka D, Sobczak I, Bartosz G, Bocer T, Ułaszewski S, Goffeau A.

FEMS Yeast Res. 2010 Nov;10(7):828-38. doi: 10.1111/j.1567-1364.2010.00673.x. Epub 2010 Sep 15.

18.

Yeast ATP-binding cassette transporters conferring multidrug resistance.

Prasad R, Goffeau A.

Annu Rev Microbiol. 2012;66:39-63. doi: 10.1146/annurev-micro-092611-150111. Epub 2012 Jun 11. Review.

PMID:
22703054
19.

Evidence for a molecular diode-based mechanism in a multispecific ATP-binding cassette (ABC) exporter: SER-1368 as a gatekeeping residue in the yeast multidrug transporter Pdr5.

Mehla J, Ernst R, Moore R, Wakschlag A, Marquis MK, Ambudkar SV, Golin J.

J Biol Chem. 2014 Sep 19;289(38):26597-606. doi: 10.1074/jbc.M114.586032. Epub 2014 Aug 11.

20.
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