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Results: 1 to 20 of 196

1.

Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model.

Kleinjan A, van Nimwegen M, Leman K, Hoogsteden HC, Lambrecht BN.

Allergy. 2013 Feb;68(2):204-12. doi: 10.1111/all.12082. Epub 2012 Dec 18.

PMID:
23253209
[PubMed - indexed for MEDLINE]
2.

United airways: circulating Th2 effector cells in an allergic rhinitis model are responsible for promoting lower airways inflammation.

KleinJan A, Willart M, van Nimwegen M, Leman K, Hoogsteden HC, Hendriks RW, Lambrecht BN.

Clin Exp Allergy. 2010 Mar;40(3):494-504. doi: 10.1111/j.1365-2222.2009.03417.x. Epub 2009 Nov 25.

PMID:
19968652
[PubMed - indexed for MEDLINE]
3.

Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.

Reines I, Kietzmann M, Mischke R, Tschernig T, Lüth A, Kleuser B, Bäumer W.

J Invest Dermatol. 2009 Aug;129(8):1954-62. doi: 10.1038/jid.2008.454. Epub 2009 Feb 5.

PMID:
19194476
[PubMed - indexed for MEDLINE]
Free Article
4.

FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice.

Nofer JR, Bot M, Brodde M, Taylor PJ, Salm P, Brinkmann V, van Berkel T, Assmann G, Biessen EA.

Circulation. 2007 Jan 30;115(4):501-8. Epub 2007 Jan 22.

PMID:
17242282
[PubMed - indexed for MEDLINE]
Free Article
5.

Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.

Schaper K, Dickhaut J, Japtok L, Kietzmann M, Mischke R, Kleuser B, Bäumer W.

J Dermatol Sci. 2013 Jul;71(1):29-36. doi: 10.1016/j.jdermsci.2013.03.006. Epub 2013 Apr 6.

PMID:
23643308
[PubMed - indexed for MEDLINE]
6.

Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy.

Kurashima Y, Kunisawa J, Higuchi M, Gohda M, Ishikawa I, Takayama N, Shimizu M, Kiyono H.

J Immunol. 2007 Aug 1;179(3):1577-85.

PMID:
17641024
[PubMed - indexed for MEDLINE]
Free Article
7.

Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.

Maeda Y, Seki N, Sato N, Sugahara K, Chiba K.

Int Immunol. 2010 Jun;22(6):515-25. doi: 10.1093/intimm/dxq036. Epub 2010 May 23.

PMID:
20497959
[PubMed - indexed for MEDLINE]
Free Article
8.

The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.

Sawicka E, Dubois G, Jarai G, Edwards M, Thomas M, Nicholls A, Albert R, Newson C, Brinkmann V, Walker C.

J Immunol. 2005 Dec 15;175(12):7973-80.

PMID:
16339533
[PubMed - indexed for MEDLINE]
Free Article
9.

The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors.

Gräler MH, Goetzl EJ.

FASEB J. 2004 Mar;18(3):551-3. Epub 2004 Jan 8.

PMID:
14715694
[PubMed - indexed for MEDLINE]
Free Article
10.

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.

Clemens JJ, Davis MD, Lynch KR, Macdonald TL.

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3568-72.

PMID:
15982878
[PubMed - indexed for MEDLINE]
11.

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.

Kihara A, Igarashi Y.

Biochim Biophys Acta. 2008 Sep;1781(9):496-502. doi: 10.1016/j.bbalip.2008.05.003. Epub 2008 Jun 13. Review.

PMID:
18555808
[PubMed - indexed for MEDLINE]
Free Article
12.

The sphingosine-1-phosphate receptor agonist FTY720 prevents the development of anti-glomerular basement membrane glomerulonephritis.

Sui M, Zhou J, Xie R, Liu X, Mu S, Jia X, Ma J, Wu H.

Mol Biol Rep. 2012 Jan;39(1):389-97. doi: 10.1007/s11033-011-0750-1. Epub 2011 Aug 11.

PMID:
21833515
[PubMed - indexed for MEDLINE]
13.

Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.

Idzko M, Hammad H, van Nimwegen M, Kool M, Müller T, Soullié T, Willart MA, Hijdra D, Hoogsteden HC, Lambrecht BN.

J Clin Invest. 2006 Nov;116(11):2935-44.

PMID:
17080194
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury.

Peng X, Hassoun PM, Sammani S, McVerry BJ, Burne MJ, Rabb H, Pearse D, Tuder RM, Garcia JG.

Am J Respir Crit Care Med. 2004 Jun 1;169(11):1245-51. Epub 2004 Mar 12.

PMID:
15020292
[PubMed - indexed for MEDLINE]
15.

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.

Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6. doi: 10.1073/pnas.1014154108. Epub 2010 Dec 21.

PMID:
21177428
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration.

Hwang SJ, Kim JH, Kim HY, Kim S, Chung DH.

Lab Invest. 2010 Jan;90(1):9-19. doi: 10.1038/labinvest.2009.109. Epub 2009 Oct 12.

PMID:
19823172
[PubMed - indexed for MEDLINE]
Free Article
17.

Sphingosine-1-phosphate and the immunosuppressant, FTY720-phosphate, regulate detrusor muscle tone.

Watterson KR, Berg KM, Kapitonov D, Payne SG, Miner AS, Bittman R, Milstien S, Ratz PH, Spiegel S.

FASEB J. 2007 Sep;21(11):2818-28. Epub 2007 Apr 20.

PMID:
17449719
[PubMed - indexed for MEDLINE]
Free Article
18.

The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice.

Keul P, Tölle M, Lucke S, von Wnuck Lipinski K, Heusch G, Schuchardt M, van der Giet M, Levkau B.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):607-13. Epub 2006 Dec 7.

PMID:
17158351
[PubMed - indexed for MEDLINE]
Free Article
19.

Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells.

Xie JH, Nomura N, Koprak SL, Quackenbush EJ, Forrest MJ, Rosen H.

J Immunol. 2003 Apr 1;170(7):3662-70.

PMID:
12646631
[PubMed - indexed for MEDLINE]
Free Article
20.

Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.

Sawicka E, Zuany-Amorim C, Manlius C, Trifilieff A, Brinkmann V, Kemeny DM, Walker C.

J Immunol. 2003 Dec 1;171(11):6206-14.

PMID:
14634137
[PubMed - indexed for MEDLINE]
Free Article

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