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Items: 1 to 20 of 89

1.

Dynamics of tumor hypoxia in response to patupilone and ionizing radiation.

Orlowski K, Rohrer Bley C, Zimmermann M, Vuong V, Hug D, Soltermann A, Broggini-Tenzer A, Pruschy M.

PLoS One. 2012;7(12):e51476. doi: 10.1371/journal.pone.0051476. Epub 2012 Dec 10.

2.

Regulation of VEGF-expression by patupilone and ionizing radiation in lung adenocarcinoma cells.

Rohrer Bley C, Orlowski K, Furmanova P, McSheehy PM, Pruschy M.

Lung Cancer. 2011 Sep;73(3):294-301. doi: 10.1016/j.lungcan.2011.01.010. Epub 2011 Feb 17.

PMID:
21333376
3.

Role of the microenvironment for radiosensitization by patupilone.

Bley CR, Jochum W, Orlowski K, Furmanova P, Vuong V, McSheehy PM, Pruschy M.

Clin Cancer Res. 2009 Feb 15;15(4):1335-42. doi: 10.1158/1078-0432.CCR-08-0969.

4.

The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.

Oehler C, von Bueren AO, Furmanova P, Broggini-Tenzer A, Orlowski K, Rutkowski S, Frei K, Grotzer MA, Pruschy M.

Neuro Oncol. 2011 Sep;13(9):1000-10. doi: 10.1093/neuonc/nor069. Epub 2011 Jul 9.

5.

Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.

Hofstetter B, Vuong V, Broggini-Tenzer A, Bodis S, Ciernik IF, Fabbro D, Wartmann M, Folkers G, Pruschy M.

Clin Cancer Res. 2005 Feb 15;11(4):1588-96.

6.

The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion.

Furmanova-Hollenstein P, Broggini-Tenzer A, Eggel M, Millard AL, Pruschy M.

Radiat Oncol. 2013 Apr 30;8:105. doi: 10.1186/1748-717X-8-105.

7.

Ionizing radiation induces tumor cell lysyl oxidase secretion.

Shen CJ, Sharma A, Vuong DV, Erler JT, Pruschy M, Broggini-Tenzer A.

BMC Cancer. 2014 Jul 22;14:532. doi: 10.1186/1471-2407-14-532.

8.

Significance of HIF-1-active cells in angiogenesis and radioresistance.

Harada H, Kizaka-Kondoh S, Li G, Itasaka S, Shibuya K, Inoue M, Hiraoka M.

Oncogene. 2007 Nov 29;26(54):7508-16. Epub 2007 Jun 11.

PMID:
17563752
10.

Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment.

Riesterer O, Honer M, Jochum W, Oehler C, Ametamey S, Pruschy M.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3518-24.

11.
12.

Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors.

Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, Olive P.

Cancer Res. 2005 Aug 15;65(16):7259-66.

13.

The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts.

Harada H, Kizaka-Kondoh S, Itasaka S, Shibuya K, Morinibu A, Shinomiya K, Hiraoka M.

Biochem Biophys Res Commun. 2007 Sep 7;360(4):791-6. Epub 2007 Jul 5.

PMID:
17624305
14.

Quinoxaline 1,4-dioxides are novel angiogenesis inhibitors that potentiate antitumor effects of ionizing radiation.

Gali-Muhtasib H, Sidani M, Geara F, Mona AD, Al-Hmaira J, Haddadin MJ, Zaatari G.

Int J Oncol. 2004 May;24(5):1121-31.

PMID:
15067333
15.

Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.

O'Reilly T, Wartmann M, Brueggen J, Allegrini PR, Floersheimer A, Maira M, McSheehy PM.

Cancer Chemother Pharmacol. 2008 Nov;62(6):1045-54. doi: 10.1007/s00280-008-0695-9. Epub 2008 Feb 27.

PMID:
18301895
16.

Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis.

Chang CC, Lin MT, Lin BR, Jeng YM, Chen ST, Chu CY, Chen RJ, Chang KJ, Yang PC, Kuo ML.

J Natl Cancer Inst. 2006 Jul 19;98(14):984-95.

17.

Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition.

Rapisarda A, Hollingshead M, Uranchimeg B, Bonomi CA, Borgel SD, Carter JP, Gehrs B, Raffeld M, Kinders RJ, Parchment R, Anver MR, Shoemaker RH, Melillo G.

Mol Cancer Ther. 2009 Jul;8(7):1867-77. doi: 10.1158/1535-7163.MCT-09-0274. Epub 2009 Jul 7.

18.

Metabolism of tumors under treatment: mapping of metabolites with quantitative bioluminescence.

Broggini-Tenzer A, Vuong V, Pruschy M.

Radiother Oncol. 2011 Jun;99(3):398-403. doi: 10.1016/j.radonc.2011.05.041. Epub 2011 Jun 12.

PMID:
21665309
19.

Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1α and induces G2/M arrest under hypoxia in prostate cancer cells.

Manohar SM, Padgaonkar AA, Jalota-Badhwar A, Rao SV, Joshi KS.

Prostate Cancer Prostatic Dis. 2012 Mar;15(1):15-27. doi: 10.1038/pcan.2011.51. Epub 2011 Nov 15.

PMID:
22083267
20.
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