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Items: 1 to 20 of 79

1.

ζ Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance.

Poliani PL, Fontana E, Roifman CM, Notarangelo LD.

J Allergy Clin Immunol. 2013 Feb;131(2):597-600.e1-2. doi: 10.1016/j.jaci.2012.11.002. Epub 2012 Dec 14. No abstract available.

PMID:
23245794
2.

A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.

Cauwe B, Tian L, Franckaert D, Pierson W, Staats KA, Schlenner SM, Liston A.

Immunology. 2014 Mar;141(3):377-87. doi: 10.1111/imm.12199.

3.

Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome.

Poliani PL, Facchetti F, Ravanini M, Gennery AR, Villa A, Roifman CM, Notarangelo LD.

Blood. 2009 Jul 2;114(1):105-8. doi: 10.1182/blood-2009-03-211029. Epub 2009 May 4.

4.

Characterization of ζ-associated protein, 70 kd (ZAP70)-deficient human lymphocytes.

Roifman CM, Dadi H, Somech R, Nahum A, Sharfe N.

J Allergy Clin Immunol. 2010 Dec;126(6):1226-33.e1. doi: 10.1016/j.jaci.2010.07.029.

PMID:
20864151
5.

Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells.

Somech R, Simon AJ, Lev A, Dalal I, Spirer Z, Goldstein I, Nagar M, Amariglio N, Rechavi G, Roifman CM.

J Allergy Clin Immunol. 2009 Oct;124(4):793-800. doi: 10.1016/j.jaci.2009.06.048. Epub 2009 Sep 19.

PMID:
19767069
6.

Differentiation of human thymic regulatory T cells at the double positive stage.

Nunes-Cabaço H, Caramalho I, Sepúlveda N, Sousa AE.

Eur J Immunol. 2011 Dec;41(12):3604-14. doi: 10.1002/eji.201141614. Epub 2011 Oct 24.

7.

NF-κB-inducing kinase in thymic stroma establishes central tolerance by orchestrating cross-talk with not only thymocytes but also dendritic cells.

Mouri Y, Nishijima H, Kawano H, Hirota F, Sakaguchi N, Morimoto J, Matsumoto M.

J Immunol. 2014 Nov 1;193(9):4356-67. doi: 10.4049/jimmunol.1400389. Epub 2014 Sep 26.

8.

Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus.

Hanabuchi S, Ito T, Park WR, Watanabe N, Shaw JL, Roman E, Arima K, Wang YH, Voo KS, Cao W, Liu YJ.

J Immunol. 2010 Mar 15;184(6):2999-3007. doi: 10.4049/jimmunol.0804106. Epub 2010 Feb 19.

9.

SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling.

Hauck F, Blumenthal B, Fuchs S, Lenoir C, Martin E, Speckmann C, Vraetz T, Mannhardt-Laakmann W, Lambert N, Gil M, Borte S, Audrain M, Schwarz K, Lim A, Schamel WW, Fischer A, Ehl S, Rensing-Ehl A, Picard C, Latour S.

Clin Immunol. 2015 Dec;161(2):103-9. doi: 10.1016/j.clim.2015.07.002. Epub 2015 Jul 14.

PMID:
26187144
10.

FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.

Schildknecht A, Brauer S, Brenner C, Lahl K, Schild H, Sparwasser T, Probst HC, van den Broek M.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):199-203. doi: 10.1073/pnas.0910620107. Epub 2009 Dec 15.

11.

Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder.

Karaca E, Karakoc-Aydiner E, Bayrak OF, Keles S, Sevli S, Barlan IB, Yuksel A, Chatila TA, Ozen M.

Gene. 2013 Jan 10;512(2):189-93. doi: 10.1016/j.gene.2012.10.062. Epub 2012 Nov 2.

PMID:
23124046
12.

Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus.

Watanabe N, Wang YH, Lee HK, Ito T, Wang YH, Cao W, Liu YJ.

Nature. 2005 Aug 25;436(7054):1181-5.

13.

CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation.

Tosiek MJ, Gruber AD, Bader SR, Mauel S, Hoymann HG, Prettin S, Tschernig T, Buer J, Gereke M, Bruder D.

J Immunol. 2011 Jun 1;186(11):6106-18. doi: 10.4049/jimmunol.1000632. Epub 2011 Apr 25.

14.

Analysis of APC types involved in CD4 tolerance and regulatory T cell generation using reaggregated thymic organ cultures.

Guerri L, Peguillet I, Geraldo Y, Nabti S, Premel V, Lantz O.

J Immunol. 2013 Mar 1;190(5):2102-10. doi: 10.4049/jimmunol.1202883. Epub 2013 Jan 30.

15.

Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.

Robb RJ, Lineburg KE, Kuns RD, Wilson YA, Raffelt NC, Olver SD, Varelias A, Alexander KA, Teal BE, Sparwasser T, Hammerling GJ, Markey KA, Koyama M, Clouston AD, Engwerda CR, Hill GR, MacDonald KP.

Blood. 2012 Jun 14;119(24):5898-908. doi: 10.1182/blood-2011-12-396119. Epub 2012 Apr 26.

16.

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells.

Aschenbrenner K, D'Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, Swee LK, Rolink A, Klein L.

Nat Immunol. 2007 Apr;8(4):351-8. Epub 2007 Feb 25.

PMID:
17322887
17.

Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development.

Spence PJ, Green EA.

Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):973-8. doi: 10.1073/pnas.0709071105. Epub 2008 Jan 15.

18.

Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

Hubert FX, Kinkel SA, Davey GM, Phipson B, Mueller SN, Liston A, Proietto AI, Cannon PZ, Forehan S, Smyth GK, Wu L, Goodnow CC, Carbone FR, Scott HS, Heath WR.

Blood. 2011 Sep 1;118(9):2462-72. doi: 10.1182/blood-2010-06-286393. Epub 2011 Apr 19.

19.

Self-encounters of the third kind: lymph node stroma promotes tolerance to peripheral tissue antigens.

Collier AY, Lee JW, Turley SJ.

Mucosal Immunol. 2008 Jul;1(4):248-51. doi: 10.1038/mi.2008.19. Epub 2008 May 14. Erratum in: Mucosal Immunol. 2008 Nov;1(6):508.

PMID:
19079186
20.

Essential role for ZAP-70 in both positive and negative selection of thymocytes.

Negishi I, Motoyama N, Nakayama K, Nakayama K, Senju S, Hatakeyama S, Zhang Q, Chan AC, Loh DY.

Nature. 1995 Aug 3;376(6539):435-8.

PMID:
7630421
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