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Results: 1 to 20 of 264

1.

Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

Spender LC, Carter MJ, O'Brien DI, Clark LJ, Yu J, Michalak EM, Happo L, Cragg MS, Inman GJ.

J Biol Chem. 2013 Feb 15;288(7):5198-209. doi: 10.1074/jbc.M112.410274. Epub 2012 Dec 14.

PMID:
23243310
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

TGF-beta induces apoptosis in human B cells by transcriptional regulation of BIK and BCL-XL.

Spender LC, O'Brien DI, Simpson D, Dutt D, Gregory CD, Allday MJ, Clark LJ, Inman GJ.

Cell Death Differ. 2009 Apr;16(4):593-602. doi: 10.1038/cdd.2008.183. Epub 2009 Jan 9.

PMID:
19136942
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation.

Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH.

J Biol Chem. 2004 Feb 27;279(9):8076-83. Epub 2003 Nov 21.

PMID:
14634023
[PubMed - indexed for MEDLINE]
Free Article
4.

Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.

Garrison SP, Jeffers JR, Yang C, Nilsson JA, Hall MA, Rehg JE, Yue W, Yu J, Zhang L, Onciu M, Sample JT, Cleveland JL, Zambetti GP.

Mol Cell Biol. 2008 Sep;28(17):5391-402. doi: 10.1128/MCB.00907-07. Epub 2008 Jun 23.

PMID:
18573879
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3.

Hemmati PG, Müer A, Gillissen B, Overkamp T, Milojkovic A, Wendt J, Dörken B, Daniel PT.

J Mol Med (Berl). 2010 Jun;88(6):609-22. doi: 10.1007/s00109-010-0606-5. Epub 2010 Apr 25.

PMID:
20419447
[PubMed - indexed for MEDLINE]
6.

Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.

Lee SH, Jung YS, Chung JY, Oh AY, Lee SJ, Choi DH, Jang SM, Jang KS, Paik SS, Ha NC, Park BJ.

Cell Death Dis. 2011 Dec 1;2:e235. doi: 10.1038/cddis.2011.116.

PMID:
22130069
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Characterization of transforming growth factor-beta 1 induced apoptosis in normal human B cells and lymphoma B cell lines.

Chaouchi N, Arvanitakis L, Auffredou MT, Blanchard DA, Vazquez A, Sharma S.

Oncogene. 1995 Oct 19;11(8):1615-22.

PMID:
7478586
[PubMed - indexed for MEDLINE]
8.

c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1.

Campone M, Noël B, Couriaud C, Grau M, Guillemin Y, Gautier F, Gouraud W, Charbonnel C, Campion L, Jézéquel P, Braun F, Barré B, Coqueret O, Barillé-Nion S, Juin P.

Mol Cancer. 2011 Sep 7;10:110. doi: 10.1186/1476-4598-10-110.

PMID:
21899728
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells.

Ohgushi M, Kuroki S, Fukamachi H, O'Reilly LA, Kuida K, Strasser A, Yonehara S.

Mol Cell Biol. 2005 Nov;25(22):10017-28.

PMID:
16260615
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The p53 upregulated modulator of apoptosis (PUMA) chemosensitizes intrinsically resistant ovarian cancer cells to cisplatin by lowering the threshold set by Bcl-x(L) and Mcl-1.

Yuan Z, Cao K, Lin C, Li L, Liu HY, Zhao XY, Liu L, Deng HX, Li J, Nie CL, Wei YQ.

Mol Med. 2011;17(11-12):1262-74. doi: 10.2119/molmed.2011.00176. Epub 2011 Aug 19.

PMID:
21863213
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Identification of the gene transcription and apoptosis mediated by TGF-beta-Smad2/3-Smad4 signaling.

Yu J, Zhang L, Chen A, Xiang G, Wang Y, Wu J, Mitchelson K, Cheng J, Zhou Y.

J Cell Physiol. 2008 May;215(2):422-33.

PMID:
17960585
[PubMed - indexed for MEDLINE]
12.

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.

Mérino D, Strasser A, Bouillet P.

Oncogene. 2012 Jul 12;31(28):3392-6. doi: 10.1038/onc.2011.508. Epub 2011 Nov 14.

PMID:
22081075
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.

Li J, Lee B, Lee AS.

J Biol Chem. 2006 Mar 17;281(11):7260-70. Epub 2006 Jan 6.

PMID:
16407291
[PubMed - indexed for MEDLINE]
Free Article
14.

The murine gastrin promoter is synergistically activated by transforming growth factor-beta/Smad and Wnt signaling pathways.

Lei S, Dubeykovskiy A, Chakladar A, Wojtukiewicz L, Wang TC.

J Biol Chem. 2004 Oct 8;279(41):42492-502. Epub 2004 Jul 28.

PMID:
15292219
[PubMed - indexed for MEDLINE]
Free Article
15.

Transcription factor Sox4 is required for PUMA-mediated apoptosis induced by histone deacetylase inhibitor, TSA.

Jang SM, Kang EJ, Kim JW, Kim CH, An JH, Choi KH.

Biochem Biophys Res Commun. 2013 Aug 23;438(2):445-51. doi: 10.1016/j.bbrc.2013.07.099. Epub 2013 Jul 31.

PMID:
23916609
[PubMed - indexed for MEDLINE]
16.

Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs.

Happo L, Phipson B, Smyth GK, Strasser A, Scott CL.

Cell Death Dis. 2012 May 10;3:e306. doi: 10.1038/cddis.2012.42.

PMID:
22573037
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth.

Dudgeon C, Peng R, Wang P, Sebastiani A, Yu J, Zhang L.

Oncogene. 2012 Nov 15;31(46):4848-58. doi: 10.1038/onc.2011.644. Epub 2012 Jan 30.

PMID:
22286758
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Transcriptional and post-translational regulation of Bim is essential for TGF-β and TNF-α-induced apoptosis of gastric cancer cell.

Ha Thi HT, Lim HS, Kim J, Kim YM, Kim HY, Hong S.

Biochim Biophys Acta. 2013 Jun;1830(6):3584-92. doi: 10.1016/j.bbagen.2013.03.006. Epub 2013 Mar 15.

PMID:
23500081
[PubMed - indexed for MEDLINE]
19.

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.

Michalak EM, Jansen ES, Happo L, Cragg MS, Tai L, Smyth GK, Strasser A, Adams JM, Scott CL.

Cell Death Differ. 2009 May;16(5):684-96. doi: 10.1038/cdd.2008.195. Epub 2009 Jan 16.

PMID:
19148184
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis.

Eischen CM, Roussel MF, Korsmeyer SJ, Cleveland JL.

Mol Cell Biol. 2001 Nov;21(22):7653-62.

PMID:
11604501
[PubMed - indexed for MEDLINE]
Free PMC Article

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