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Results: 1 to 20 of 102

1.

Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism.

Hu ZY, Parker RB, Herring VL, Laizure SC.

Anal Bioanal Chem. 2013 Feb;405(5):1695-704. doi: 10.1007/s00216-012-6576-4. Epub 2012 Dec 14.

PMID:
23239178
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis.

Laizure SC, Parker RB, Herring VL, Hu ZY.

Drug Metab Dispos. 2014 Feb;42(2):201-6. doi: 10.1124/dmd.113.054353. Epub 2013 Nov 8.

PMID:
24212379
[PubMed - indexed for MEDLINE]
3.

Impact of endogenous esterase activity on in vitro p-glycoprotein profiling of dabigatran etexilate in Caco-2 monolayers.

Ishiguro N, Kishimoto W, Volz A, Ludwig-Schwellinger E, Ebner T, Schaefer O.

Drug Metab Dispos. 2014 Feb;42(2):250-6. doi: 10.1124/dmd.113.053561. Epub 2013 Nov 8.

PMID:
24212377
[PubMed - indexed for MEDLINE]
4.

The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans.

Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W.

Drug Metab Dispos. 2008 Feb;36(2):386-99. Epub 2007 Nov 15.

PMID:
18006647
[PubMed - indexed for MEDLINE]
Free Article
5.

Quantitative estimation of circulating metabolites without synthetic standards by ultra-high-performance liquid chromatography/high resolution accurate mass spectrometry in combination with UV correction.

Yang Y, Grubb MF, Luk CE, Humphreys WG, Josephs JL.

Rapid Commun Mass Spectrom. 2011 Nov 15;25(21):3245-51. doi: 10.1002/rcm.5220.

PMID:
22006386
[PubMed - indexed for MEDLINE]
7.

Characterization of the metabolism of sibiricaxanthone F and its aglycone in vitro by high performance liquid chromatography coupled with Q-trap mass spectrometry.

Song Y, Yang X, Jiang Y, Tu P.

J Pharm Biomed Anal. 2012 Nov;70:700-7. doi: 10.1016/j.jpba.2012.06.038. Epub 2012 Jul 3.

PMID:
22819207
[PubMed - indexed for MEDLINE]
8.

A simple liquid chromatography-tandem mass spectrometry method to determine relative plasma exposures of drug metabolites across species for metabolite safety assessments.

Gao H, Deng S, Obach RS.

Drug Metab Dispos. 2010 Dec;38(12):2147-56. doi: 10.1124/dmd.110.034637. Epub 2010 Sep 16.

PMID:
20847138
[PubMed - indexed for MEDLINE]
Free Article
10.

Metabolite identification of a new antitumor agent icotinib in rats using liquid chromatography/tandem mass spectrometry.

Guan Z, Chen X, Wang Y, Zhong D.

Rapid Commun Mass Spectrom. 2008 Jul;22(14):2176-84. doi: 10.1002/rcm.3599.

PMID:
18536068
[PubMed - indexed for MEDLINE]
11.
12.

UPLC MS/MS assay for routine quantification of dabigatran - a direct thrombin inhibitor - in human plasma.

Delavenne X, Moracchini J, Laporte S, Mismetti P, Basset T.

J Pharm Biomed Anal. 2012 Jan 25;58:152-6. doi: 10.1016/j.jpba.2011.09.018. Epub 2011 Sep 22.

PMID:
21996066
[PubMed - indexed for MEDLINE]
13.

Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats.

Luo CF, Yuan M, Chen MS, Liu SM, Ji H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 1;878(3-4):363-70. doi: 10.1016/j.jchromb.2009.12.002. Epub 2009 Dec 5.

PMID:
20006564
[PubMed - indexed for MEDLINE]
14.

Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap.

Gao H, Materne OL, Howe DL, Brummel CL.

Rapid Commun Mass Spectrom. 2007;21(22):3683-93.

PMID:
17937450
[PubMed - indexed for MEDLINE]
15.

Metabolite identification of a new tyrosine kinase inhibitor, HM781-36B, and a pharmacokinetic study by liquid chromatography/tandem mass spectrometry.

Kim E, Kim H, Suh K, Kwon S, Lee G, Park NH, Hong J.

Rapid Commun Mass Spectrom. 2013 Jun 15;27(11):1183-95. doi: 10.1002/rcm.6559.

PMID:
23650031
[PubMed - indexed for MEDLINE]
16.

Quantitation of parent drug and its unstable metabolites by in situ coulometric oxidation and liquid chromatography-tandem mass spectrometry.

Tong W, Chowdhury SK, Su AD, Alton KB.

Anal Chem. 2010 Dec 15;82(24):10251-7. doi: 10.1021/ac102538s. Epub 2010 Nov 24.

PMID:
21105697
[PubMed - indexed for MEDLINE]
17.

Identification of liguzinediol metabolites in rats by ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry.

Shan CX, Li W, Wen HM, Wang XZ, Zhu YH, Cui XB.

J Pharm Biomed Anal. 2012 Mar 25;62:187-90. doi: 10.1016/j.jpba.2011.12.016. Epub 2012 Jan 5.

PMID:
22277354
[PubMed - indexed for MEDLINE]
18.

Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification.

Li AC, Ding J, Jiang X, Denissen J.

Rapid Commun Mass Spectrom. 2009 Sep;23(18):3003-12. doi: 10.1002/rcm.4207.

PMID:
19681099
[PubMed - indexed for MEDLINE]
19.
20.

Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor.

ter Heine R, Hillebrand MJ, Rosing H, van Gorp EC, Mulder JW, Beijnen JH, Huitema AD.

Drug Metab Dispos. 2009 Sep;37(9):1826-40. doi: 10.1124/dmd.109.028258. Epub 2009 Jun 22.

PMID:
19546238
[PubMed - indexed for MEDLINE]
Free Article

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