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JAK kinases are required for the bacterial RNA and poly I:C induced tyrosine phosphorylation of PKR.

Bleiblo F, Michael P, Brabant D, Ramana CV, Tai T, Saleh M, Parrillo JE, Kumar A, Kumar A.

Int J Clin Exp Med. 2013;6(1):16-25. Epub 2012 Nov 18.


Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2.

Su Q, Wang S, Baltzis D, Qu LK, Raven JF, Li S, Wong AH, Koromilas AE.

EMBO Rep. 2007 Mar;8(3):265-70. Epub 2007 Feb 9.


Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins.

Vignais ML, Sadowski HB, Watling D, Rogers NC, Gilman M.

Mol Cell Biol. 1996 Apr;16(4):1759-69.


Beta interferon and oncostatin M activate Raf-1 and mitogen-activated protein kinase through a JAK1-dependent pathway.

Stancato LF, Sakatsume M, David M, Dent P, Dong F, Petricoin EF, Krolewski JJ, Silvennoinen O, Saharinen P, Pierce J, Marshall CJ, Sturgill T, Finbloom DS, Larner AC.

Mol Cell Biol. 1997 Jul;17(7):3833-40.


Characterization of the heparin-mediated activation of PKR, the interferon-inducible RNA-dependent protein kinase.

George CX, Thomis DC, McCormack SJ, Svahn CM, Samuel CE.

Virology. 1996 Jul 1;221(1):180-8.


Peptides derived from the interferon-induced PKR prevent activation by HIV-1 TAR RNA.

Nekhai S, Kumar A, Bottaro DP, Petryshyn R.

Virology. 1996 Aug 1;222(1):193-200.


Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.

Wong AH, Tam NW, Yang YL, Cuddihy AR, Li S, Kirchhoff S, Hauser H, Decker T, Koromilas AE.

EMBO J. 1997 Mar 17;16(6):1291-304.


DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR.

Patel RC, Vestal DJ, Xu Z, Bandyopadhyay S, Guo W, Erme SM, Williams BR, Sen GC.

J Biol Chem. 1999 Jul 16;274(29):20432-7.


Innate cytokine responses in porcine macrophage populations: evidence for differential recognition of double-stranded RNA.

Loving CL, Brockmeier SL, Ma W, Richt JA, Sacco RE.

J Immunol. 2006 Dec 15;177(12):8432-9.


Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA.

Takeuchi K, Komatsu T, Kitagawa Y, Sada K, Gotoh B.

J Virol. 2008 Oct;82(20):10102-10. doi: 10.1128/JVI.00599-08. Epub 2008 Aug 6.


Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I).poly (C) in endothelial cells.

Offermann MK, Zimring J, Mellits KH, Hagan MK, Shaw R, Medford RM, Mathews MB, Goodbourn S, Jagus R.

Eur J Biochem. 1995 Aug 15;232(1):28-36.


Expression of unphosphorylated form of human double-stranded RNA-activated protein kinase in Escherichia coli.

Matsui T, Tanihara K, Date T.

Biochem Biophys Res Commun. 2001 Jun 15;284(3):798-807.

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