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Results: 1 to 20 of 119

1.

In cardiomyocytes, binding of unzipping peptide activates ryanodine receptor 2 and reciprocally inhibits calmodulin binding.

Oda T, Yang Y, Nitu FR, Svensson B, Lu X, Fruen BR, Cornea RL, Bers DM.

Circ Res. 2013 Feb 1;112(3):487-97. doi: 10.1161/CIRCRESAHA.111.300290. Epub 2012 Dec 11.

PMID:
23233753
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.

Yang Y, Guo T, Oda T, Chakraborty A, Chen L, Uchinoumi H, Knowlton AA, Fruen BR, Cornea RL, Meissner G, Bers DM.

Circ Res. 2014 Jan 17;114(2):295-306. doi: 10.1161/CIRCRESAHA.114.302857. Epub 2013 Nov 1.

PMID:
24186966
[PubMed - indexed for MEDLINE]
3.

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.

Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2010 Sep 1;87(4):609-17. doi: 10.1093/cvr/cvq108. Epub 2010 Apr 13.

PMID:
20388639
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks.

Guo T, Cornea RL, Huke S, Camors E, Yang Y, Picht E, Fruen BR, Bers DM.

Circ Res. 2010 Jun 11;106(11):1743-52. doi: 10.1161/CIRCRESAHA.110.219816. Epub 2010 Apr 29.

PMID:
20431056
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.

Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2009 Feb 15;81(3):536-45. doi: 10.1093/cvr/cvn303. Epub 2008 Nov 7.

PMID:
18996969
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

FRET detection of calmodulin binding to the cardiac RyR2 calcium release channel.

Guo T, Fruen BR, Nitu FR, Nguyen TD, Yang Y, Cornea RL, Bers DM.

Biophys J. 2011 Nov 2;101(9):2170-7. doi: 10.1016/j.bpj.2011.09.030. Epub 2011 Nov 1.

PMID:
22067155
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Defective regulation of interdomain interactions within the ryanodine receptor plays a key role in the pathogenesis of heart failure.

Oda T, Yano M, Yamamoto T, Tokuhisa T, Okuda S, Doi M, Ohkusa T, Ikeda Y, Kobayashi S, Ikemoto N, Matsuzaki M.

Circulation. 2005 Jun 28;111(25):3400-10. Epub 2005 Jun 20. Erratum in: Circulation. 2005 Oct 25;112(17):e291.

PMID:
15967847
[PubMed - indexed for MEDLINE]
Free Article
8.

Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain.

Zissimopoulos S, Lai FA.

J Biol Chem. 2005 Feb 18;280(7):5475-85. Epub 2004 Dec 9.

PMID:
15591045
[PubMed - indexed for MEDLINE]
Free Article
9.

Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6.

Zissimopoulos S, Lai FA.

Cell Biochem Biophys. 2005;43(2):203-19.

PMID:
16049346
[PubMed - indexed for MEDLINE]
10.

FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.

Galfré E, Pitt SJ, Venturi E, Sitsapesan M, Zaccai NR, Tsaneva-Atanasova K, O'Neill S, Sitsapesan R.

PLoS One. 2012;7(2):e31956. doi: 10.1371/journal.pone.0031956. Epub 2012 Feb 21.

PMID:
22363773
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The RyR2 central domain peptide DPc10 lowers the threshold for spontaneous Ca2+ release in permeabilized cardiomyocytes.

Yang Z, Ikemoto N, Lamb GD, Steele DS.

Cardiovasc Res. 2006 Jun 1;70(3):475-85. Epub 2006 Mar 7. Erratum in: Cardiovasc Res. 2006 Aug 1;71(3):606.

PMID:
16624262
[PubMed - indexed for MEDLINE]
Free Article
12.

Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts.

Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.

Cardiovasc Res. 2012 Dec 1;96(3):433-43. doi: 10.1093/cvr/cvs271. Epub 2012 Aug 14.

PMID:
22893680
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.

Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6. doi: 10.1016/j.bbrc.2010.03.046. Epub 2010 Mar 10.

PMID:
20226167
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor.

Sharma MR, Jeyakumar LH, Fleischer S, Wagenknecht T.

Biophys J. 2006 Jan 1;90(1):164-72. Epub 2005 Oct 7.

PMID:
16214874
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer.

Cornea RL, Nitu FR, Samsó M, Thomas DD, Fruen BR.

J Biol Chem. 2010 Jun 18;285(25):19219-26. doi: 10.1074/jbc.M109.066944. Epub 2010 Apr 19.

PMID:
20404344
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC.

Circ Res. 2014 Mar 28;114(7):1114-24. doi: 10.1161/CIRCRESAHA.114.303391. Epub 2014 Feb 21.

PMID:
24563457
[PubMed - indexed for MEDLINE]
17.

Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia.

Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M.

Circulation. 2011 Aug 9;124(6):682-94. doi: 10.1161/CIRCULATIONAHA.111.023259. Epub 2011 Jul 18.

PMID:
21768539
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.

Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.

Circulation. 2008 Feb 12;117(6):762-72. doi: 10.1161/CIRCULATIONAHA.107.718957. Epub 2008 Jan 28.

PMID:
18227387
[PubMed - indexed for MEDLINE]
Free Article
19.

Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors.

Sigalas C, Bent S, Kitmitto A, O'Neill S, Sitsapesan R.

Br J Pharmacol. 2009 Mar;156(5):794-806. doi: 10.1111/j.1476-5381.2008.00092.x. Epub 2009 Feb 3.

PMID:
19220289
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor.

Wang R, Zhong X, Meng X, Koop A, Tian X, Jones PP, Fruen BR, Wagenknecht T, Liu Z, Chen SR.

J Biol Chem. 2011 Apr 8;286(14):12202-12. doi: 10.1074/jbc.M110.194316. Epub 2011 Jan 24.

PMID:
21262961
[PubMed - indexed for MEDLINE]
Free PMC Article

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